The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Cellular and molecular mechanisms of repair in acute and chronic wound healing
Open accessAbstract
A considerable understanding of the fundamental cellular and molecular mechanisms underpinning healthy acute wound healing has been gleaned from studying various animal models, and we are now unravelling the mechanisms that lead to chronic wounds and pathological healing including fibrosis. A small cut will normally heal in days through tight orchestration of cell migration and appropriate levels of inflammation, innervation and angiogenesis. Major surgeries may take several weeks to heal and leave behind a noticeable scar. At the extreme end, chronic wounds - defined as a barrier defect that has not healed in 3 months - have become a major therapeutic challenge throughout the Western world and will only increase as our populations advance in age, and with the increasing incidence of diabetes, obesity and vascular disorders. Here we describe the clinical problems and how, through better dialogue between basic researchers and clinicians, we may extend our current knowledge to enable the development of novel potential therapeutic treatments.
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Cites
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Cited by
Modern Wound Dressings: Hydrogel Dressings
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Chronic wounds: Treatment consensus
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Chronic wounds: Current status, available strategies and emerging therapeutic solutions
Las Heras, K., Igartua, M., Santos-Vizcaino, E., & Hernandez, R. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.039 · Cited by 370
Metadata
- Authors
- Martin, P., & Nunan, R.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-07-14
- Volume
- 173
- Issue
- 2
- Pages
- 370-378
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W1608217646
- Cited by
- 1,127
- References
- 22
- FWCI
- 34.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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