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Cited by 445

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

PDE5 inhibitors – pharmacology and clinical applications 20 years after sildenafil discovery

Open access
Andersson, K‐E·2018·British Journal of Pharmacology
DOI 10.1111/bph.14205
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Abstract

The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many normal physiological functions and the pathophysiology of several diseases. Since the discovery and introduction of sildenafil, inhibitors of PDE5 have been the first‐line therapy for erectile dysfunction (ED). The success of sildenafil in the treatment of ED stimulated research in the field of PDE5 inhibition and led to many new applications, such as treatment of lower urinary symptoms, and pulmonary arterial hypertension, which are now approved indications. However, PDE5 inhibitors have also been used in several other disorders not discussed in this review, and the fields of clinical use are increasing. In the present review, the pharmacological basis of the NO/cGMP pathway and the rationale and clinical use of PDE5 inhibitors in different diseases are discussed.

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Metadata

Authors
Andersson, K.
Venue
British Journal of Pharmacology
Publisher
Wiley
Published
2018-04-25
Volume
175
Issue
13
Pages
2554-2565
ISSN
  • 0007-1188 (ISSN-L)
  • 1476-5381
DOI
10.1111/bph.14205
OpenAlex
W2801518413
Cited by
445
References
63
FWCI
19.85
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.