Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications

Prospective identification of tumorigenic breast cancer cells

Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,579

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., Minden, M., Paterson, B., Caligiuri, M. A., & Dick, J. E. (1994) · Nature · doi:10.1038/367645a0 · Cited by 4,783

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482

Identification and expansion of human colon-cancer-initiating cells

Ricci‐Vitiani, L., Lombardi, D. G., Pilozzi, E., Biffoni, M., Todaro, M., Peschle, C., & Maria, R. D. (2006) · Nature · doi:10.1038/nature05384 · Cited by 4,001

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium

Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., van Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.050 · Cited by 3,753

Modeling Development and Disease with Organoids

Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.

Clarke, M. F., Dick, J. E., Dirks, P. B., Eaves, C., Jamieson, C., Jones, D. L., Visvader, J., Weissman, I. L., & Wahl, G. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3126 · Cited by 3,124

The third dimension bridges the gap between cell culture and live tissue

Pampaloni, F., Reynaud, E. G., & Stelzer, E. H. K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2236 · Cited by 2,817

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint

Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

Lee, J., Kotliarova, S. E., Kotliarov, Y., Li, A., Su, Q., Donin, N. M., Pastorino, S., Purow, B. W., Christopher, N., Zhang, W., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.030 · Cited by 2,345

Anaplastic thyroid cancer spheroids as preclinical models to test therapeutics

Hu, J., Liu, K., Ghosh, C., Khaket, T. P., Shih, H. A., & Kebebew, E. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03009-8 · Cited by 16

Effects of microtubule-inhibiting small molecule and antibody-drug conjugate treatment on differentially-sized A431 squamous carcinoma spheroids

Durbin, K. R., Nottoli, M. S., & Jenkins, G. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-57789-y · Cited by 16

Life style factors, tumor cell plasticity and cancer stem cells

Chiodi, I., & Mondello, C. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108308 · Cited by 17

Characterization of stem cell-like property in cancer cells based on single-cell impedance measurement in a microfluidic platform

Lei, K. F., Ho, Y.-C., Huang, C., Huang, C., & Pai, P. C. (2021) · Talanta · doi:10.1016/j.talanta.2021.122259 · Cited by 16

Nature-Inspired Nanoparticles as Paclitaxel Targeted Carrier for the Treatment of HER2-Positive Breast Cancer

Nieto, C., Vega, M. A., & del Valle, E. M. M. (2021) · Cancers · doi:10.3390/cancers13112526 · Cited by 16

Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1

Ashley, N., Ouaret, D., & Bodmer, W. F. (2018) · The Journal of Pathology · doi:10.1002/path.5179 · Cited by 16

Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate Cancer

Pinto, C. I. G., Bucar, S., Alves, V., Fonseca, A. I., Abrunhosa, A., da Silva, C. L., Guerreiro, J. F., & Mendes, F. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.609172 · Cited by 16

MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survivalPreprint

Hurd, M., Pino, J. J., Jang, K., Allevato, M. M., Vorontchikhina, M., Ichikawa, W., Zhao, Y., Gates, R., Villalpando, E., Hamilton, M., et al. (2023) · Genes & Development · doi:10.1101/gad.350736.123 · Cited by 16

A spheroid whole mount drug testing pipeline with machine-learning based image analysis identifies cell-type specific differences in drug efficacy on a single-cell level

Vitacolonna, M., Bruch, R., Schneider, R., Jabs, J., Hafner, M., Reischl, M., & Rudolf, R. (2024) · BMC Cancer · doi:10.1186/s12885-024-13329-9 · Cited by 15

Macrophage Plasticity and Function in the Lung Tumour Microenvironment Revealed in 3D Heterotypic Spheroid and Explant Models

Evans, L., Milward, K. F., Attanoos, R. L., Clayton, A., Errington, R. J., & Tabi, Z. (2021) · Biomedicines · doi:10.3390/biomedicines9030302 · Cited by 15

Application of Cancer Cell Reprogramming Technology to Human Cancer Research

Pan, X.-Y., Tsai, M.-H., Wuputra, K., Ku, C., Lin, W., Lin, Y., Kishikawa, S., Noguchi, M., Saito, S., Lin, C., et al. (2017) · Anticancer Research · doi:10.21873/anticanres.11703 · Cited by 14

Current experimental human tissue‐derived models for prostate cancer research

Kato, M., Sasaki, T., & Inoue, T. (2020) · International Journal of Urology · doi:10.1111/iju.14441 · Cited by 15

Characterization and determination of cadmium resistance of CD133+/CD24+ and CD133−/CD24+ cells isolated from the immortalized human proximal tubule cell line, RPTEC/TERT1

Shrestha, S., Garrett, S. H., Sens, D. A., Zhou, X., Guyer, R., & Somji, S. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.05.007 · Cited by 15

Innovative organ-on-a-chip platforms for exploring tumorigenesis and therapy in head and neck cancer

Lin, C., Zhang, Z., Yang, F. L., Gu, S., Zuo, J., Wu, Y. M., Zhang, J., Zhou, T., Zhang, Y., Chen, Z., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06824-5 · Cited by 14

Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche

Li, J., Ek, F., Olsson, R., Belting, M., & Bengzon, J. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01422-8 · Cited by 14

Gundelia tournefortii inhibits hepatocellular carcinoma progression by lowering gene expression of the cell cycle and hepatocyte proliferation in immunodeficient mice

Amer, J., Salhab, A., Jaradat, N. A., Abdallah, S., Abu-Rass, H., Hattab, S., Ghanim, M. A., & Alqub, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113885 · Cited by 17

A hybrid physics-based and data-driven framework for cellular biological systems: Application to the morphogenesis of organoids

Camacho-Gómez, D., Sorzabal-Bellido, I., Ortíz-de-Solórzano, C., García-Aznar, J., & Gómez-Benito, M. (2023) · iScience · doi:10.1016/j.isci.2023.107164 · Cited by 14

Harnessing graphene oxide nanocarriers for siRNA delivery in a 3D spheroid model of lung cancer

Grilli, F., Hassan, E. M., Variola, F., & Zou, S. (2023) · Biomaterials Science · doi:10.1039/d3bm00732d · Cited by 14

Three-Dimensional Tumor Models to Study Cancer Stemness-Mediated Drug Resistance

Lamichhane, A., & Tavana, H. (2024) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-024-00798-y · Cited by 16

The combination of breast cancer PDO and mini‐PDX platform for drug screening and individualized treatment

Cui, Y., Ran, R., Da, Y., Zhang, H., Jiang, M., Qi, X., Zhang, W., Niu, L., Zhou, C., Zhou, C., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18374 · Cited by 14

Organoids in cancer therapies: a comprehensive review

Xin-Yi, J., Yan-Ran, W., Pin-Ru, D., Shi-Yi, Q., & Jiang, H. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1607488 · Cited by 17

Low-dose zoledronate for the treatment of bone metastasis secondary to prostate cancer

Akoury, E., Ahangar, P., Nour, A., Lapointe, J., Guérard, K., Haglund, L., Rosenzweig, D. H., & Weber, M. H. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0745-x · Cited by 14

Does resource availability help determine the evolutionary route to multicellularity?

Hamant, O., Bhat, R., Nanjundiah, V., & Newman, S. A. (2019) · Evolution & Development · doi:10.1111/ede.12287 · Cited by 14

Integration of Hydrogel Microparticles With Three-Dimensional Liver Progenitor Cell Spheroids

Gentile, S. D., Kourouklis, A. P., Ryoo, H., & Underhill, G. H. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00792 · Cited by 14

Genetically modified cell spheroids for tissue engineering and regenerative medicine

Jiang, Z., Xu, Y., Fu, M., Zhu, D., Li, N., & Yang, G. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.033 · Cited by 12

Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress

Martínez-Ruiz, L., Florido, J., Rodríguez-Santana, C., López‐Rodríguez, A., Guerra‐Librero, A., Fernández-Gil, B. I., García-Tárraga, P., García‐Verdugo, J. M., Oppel, F., Sudhoff, H. H., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115518 · Cited by 13

Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition

Gorji‐Bahri, G., Krishna, B. M., Hagerling, C., Orimo, A., Jirström, K., Παπαδάκος, Κ. Σ., & Blom, A. M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05083-0 · Cited by 13

Recent studies of the effects of microgravity on cancer cells and the development of 3D multicellular cancer spheroids

Grimm, D. G., Corydon, T. J., Sahana, J., González-Torres, L. F., Kraus, A., Marchal, S., Wise, P. M., Simonsen, U., & Krüger, M. (2025) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szaf008 · Cited by 15

Perfusion Bioreactor Technology for Organoid and Tissue Culture: A Mini Review

Avena, P., Zavaglia, L., Casaburi, I., & Pezzi, V. (2025) · Onco · doi:10.3390/onco5020017 · Cited by 13

A high-throughput screen identifies inhibitors of lung cancer stem cells

She, X., Gao, Y., Zhao, Y. F., Yin, Y., & Dong, Z. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111748 · Cited by 15

The anticancer effects of Metformin in the male germ tumor SEM-1 cell line are mediated by HMGA1

Salatino, A., Mirabelli, M., CHIEFARI, E. D., Greco, M., Vito, A. D., Bonapace, G., Brunetti, F. S., Crocerossa, F., Epstein, A. L., FOTI, D. P., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1051988 · Cited by 13

Three-dimensional cell cultures as preclinical models to assess the biological activity of phytochemicals in breast cancer

Okuyama, N. C. M., Ribeiro, D. L., da Rocha, C. Q., Pereira, É. R., Cólus, I. M. D. S., & Serpeloni, J. M. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116376 · Cited by 13

Primary colonospheres maintain stem cell‐like key features after cryopreservation

Eini, L., Naseri, M., Karimi‐Busheri, F., Bozorgmehr, M., Ghods, R., & Madjd, Z. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29150 · Cited by 13

Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer

Lin, Z., Li, Q., Zhao, Y., Lin, Z., Cheng, N., Zhang, D., Liu, G., Lin, J., Zhang, H., & Lin, D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.738085 · Cited by 13

A novel 3D in vitro tissue model for bone‐metastasized breast cancer: A preclinical tool in drug discovery and testing

Garakani, M. M., Cooke, M. E., Wertheimer, M. R., Rosenzweig, D. H., & Ajji, A. (2022) · Plasma Processes and Polymers · doi:10.1002/ppap.202100206 · Cited by 13

Molecular Mechanisms of Tumor Cell Stemness Modulation during Formation of Spheroids

Ponomarev, A. S., Gilazieva, Z., Solovyeva, V. V., & Rizvanov, A. A. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923070106 · Cited by 11

Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3/c-MYC axis

Signorile, M. L., Nicola, E. D., Forte, G., Sanese, P., Fasano, C., Disciglio, V., Marco, K. D., Latrofa, M., Cecco, L. D., Ficorilli, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02290-z · Cited by 15

Cancer Explant Models

Stackhouse, C. T., Gillespie, G. Y., & Willey, C. D. (2019) · Current topics in microbiology and immunology · doi:10.1007/82_2019_157 · Cited by 12

PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma

Marayati, R., Stafman, L. L., Williams, A. P., Bownes, L. V., Quinn, C. H., Aye, J. M., Stewart, J. E., Yoon, K. J., Anderson, J. C., Willey, C. D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85289-0 · Cited by 12

Isoform‐specific effects of transcription factor TCFL5 on the pluripotency‐related genes SOX2 and KLF4 in colorectal cancer development

Galán‐Martínez, J., Stamatakis, K., Sánchez‐Gómez, I., Vázquez‐Cuesta, S., Gironès, N., & Fresno, M. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13085 · Cited by 12

Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity

Morla, S., Ravikumar, O., O’Hara, C. P., Boothello, R. S., Vera, A., Abdelfadiel, E. I., Fayyad, R. M., Afosah, D. K., Sharon, C., Fernandez, L., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01511 · Cited by 12

Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes

Shao, S., Scholtz, L. U., Gendreizig, S., Martínez-Ruiz, L., Florido, J., Escames, G., Schürmann, M., Hain, C., Hose, L., Mentz, A., et al. (2023) · BMC Cancer · doi:10.1186/s12885-022-10481-y · Cited by 12

Anti-Tumor Effects of Low Dose Zoledronate on Lung Cancer-Induced Spine Metastasis

Akoury, E., Luna, A. S. R. G., Ahangar, P., Gao, X., Zolotarov, P., Weber, M. H., & Rosenzweig, D. H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081212 · Cited by 12

Proteins and Molecular Pathways Relevant for the Malignant Properties of Tumor-Initiating Pancreatic Cancer Cells

Samonig, L., Loipetzberger, A., Blöchl, C., Rurik, M., Kohlbacher, O., Aberger, F., & Huber, C. G. (2020) · Cells · doi:10.3390/cells9061397 · Cited by 12

Isolation and Characterization of Two Novel Colorectal Cancer Cell Lines, Containing a Subpopulation with Potential Stem-Like Properties: Treatment Options by MYC/NMYC Inhibition

Esch, J. S. A., Windmöller, B. A., Hanewinkel, J., Storm, J., Förster, C., Wilkens, L., Krüger, M., Kaltschmidt, B., & Kaltschmidt, C. (2020) · Cancers · doi:10.3390/cancers12092582 · Cited by 12

Model Systems for the Study of Malignant Melanoma

Gregg, R. K. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1205-7_1 · Cited by 13

Biofunctional supramolecular hydrogels fabricated from a short self-assembling peptide modified with bioactive sequences for the 3D culture of breast cancer MCF-7 cells

Chia, J. Y., Miki, T., Mihara, H., & Tsutsumi, H. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116345 · Cited by 12

Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity

Marloye, M., Inam, H., Moore, C. J., Mertens, R. T., Ingels, A., Koch, M., Nowicki, M. O., Mathieu, V., Pritchard, J. R., Awuah, S. G., et al. (2022) · Inorganic Chemistry Frontiers · doi:10.1039/d2qi00423b · Cited by 11

Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures

Kulesza, J., Paluszkiewicz, E., & Augustin, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115780 · Cited by 11

Generating human skeletal myoblast spheroids for vascular myogenic tissue engineering

Minne, M., Terrie, L., Wüst, R., Hasevoets, S., Kerchove, K. V., Nimako, K., Lambrichts, I., Thorrez, L., & Declercq, H. (2024) · Biofabrication · doi:10.1088/1758-5090/ad2fd5 · Cited by 11

Evaluation of the theranostic potential of [64Cu]CuCl2 in glioblastoma spheroids

Pinto, C. I. G., Branco, A., Bucar, S., Fonseca, A. I., Abrunhosa, A., da Silva, C. L., Guerreiro, J. F., & Mendes, F. (2024) · EJNMMI Research · doi:10.1186/s13550-024-01084-8 · Cited by 12

Cancer stem-like cells in uveal melanoma: novel insights and therapeutic implications

Loda, A., Semeraro, F., Parolini, S., Ronca, R., & Rezzola, S. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189104 · Cited by 11

Evaluation of Anticancer Efficacy of D-α-Tocopheryl Polyethylene-Glycol Succinate and Soluplus® Mixed Micelles Loaded with Olaparib and Rapamycin Against Ovarian Cancer

Shin, Y. S., Choi, J., Yoon, M., Yoo, M. K., Shin, D. H., & Lee, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s468935 · Cited by 11

Cell-Based Glioma Models for Anticancer Drug Screening: From Conventional Adherent Cell Cultures to Tumor-Specific Three-Dimensional Constructs

Lanskikh, D., Kuziakova, O., Baklanov, I., Penkova, A. O., Doroshenko, V., Buriak, I., Zhmenia, V., & Kumeiko, V. V. (2024) · Cells · doi:10.3390/cells13242085 · Cited by 12

Enhancing therapeutic efficacy through degradation of endogenous extracellular matrix in primary breast tumor spheroids

Cicero, A. L., Campora, S., Buglio, G. L., Cinà, P., Pinto, M. L., Scilabra, S. D., & Ghersi, G. (2025) · FEBS Journal · doi:10.1111/febs.70069 · Cited by 11

Osteomatrix as a personalized 3D tissue-specific invasion test-bed for oral carcinoma

Sudhakaran, S. V., Giri, P. S., Nellore, V., & Rath, S. N. (2023) · Biomaterials Science · doi:10.1039/d2bm01870e · Cited by 11

Cancer Stem Cells, Apoptosis Pathways and Mechanisms of Death Resistance

Safa, A. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811785-9.00007-7 · Cited by 11

Role of RUNX2 in breast cancer development and drug resistance (Review)

Si, W., Chen, K., Zhang, L., & Li, F. (2023) · Oncology Letters · doi:10.3892/ol.2023.13762 · Cited by 11

Human esophageal cancer stem-like cells escape the cytotoxicity of natural killer cells via down-regulation of ULBP-1

Tang, B., Guo, M., Zhai, Y., Zhang, K., Ni, K., Zhang, Y., & Huang, L. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05549-1 · Cited by 10

A combination formulation of TPGS micelles loaded with paclitaxel and olaparib and a pH-thermosensitive hydrogel for treating peritoneal metastasis and drug-resistant ovarian cancer

Jo, M. J., Yoon, M. S., Kim, S. Y., Lee, J. M., Kang, S. J., Park, C., Kim, J. S., Yoon, J., & Shin, D. H. (2025) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-024-00705-7 · Cited by 10

Pipeline to evaluate YAP-TEAD inhibitors indicates TEAD inhibition represses NF2 -mutant mesothelioma

Cunningham, R., Jia, S., Purohit, K. P., Nosková, M., Maniak, M. K., Lin, Y., Hui, N. S., Graham, R. E., Rossi, A. G., Cholewa-Waclaw, J., et al. (2025) · Life Science Alliance · doi:10.26508/lsa.202503241 · Cited by 12

Integrative analysis of transcription factors and microRNAs in ovarian cancer cell spheroids

Park, H., Hwang, S., Jeong, J.-Y., Jung, S. G., Choi, M. C., Joo, W. D., Song, S. H., Lee, C. M., & An, H. J. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00618-7 · Cited by 10

Concise review: Cancer cell reprogramming and therapeutic implications

Xiao, X., Chen, H., Yang, L., Xie, G., Shimuzu, R., & Murai, A. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101503 · Cited by 10

Organoids in the Clinic: A Systematic Review of Outcomes

Hofmann, B., Zinöcker, S., Holm, S., Lewis, J., & Kavouras, P. (2022) · Cells Tissues Organs · doi:10.1159/000527237 · Cited by 11

Ribosome display and selection of single‐chain variable fragments effectively inhibit growth and progression of microspheres in vitro and in vivo

Huang, S., Lu, F., An, G., Zhang, X., Zhao, Z., Han, R. F., Lei, F., Zhang, Y., Luo, A., Jing, X., et al. (2018) · Cancer Science · doi:10.1111/cas.13574 · Cited by 10

The Expression Analysis of Intestinal Cancer Stem Cell Marker Lgr5 in Colorectal Cancer Patients and the Correlation with Histopathological Markers

Salehizadeh, S., Hasanzad, M., Kadijani, A. A., & Akbari, A. (2019) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-019-00295-w · Cited by 10

Pleiotropic effects of probenecid on three-dimensional cultures of prostate cancer cells

Uwada, J., Mukai, S., Terada, N., Nakazawa, H., Islam, M. S., Nagai, T., Fujii, M., Yamasaki, K., Taniguchi, T., Kamoto, T., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119554 · Cited by 10

My cells, my model: immune-competent autologous organ-on-chip systems as a new paradigm in precision medicine

Bisconti, F., Abreu, H., Nguyen, T. D., Stolfi, F., Corbezzolo, N., Gigli, G., Raineri, D., Cappellano, G., Polini, A., Gervaso, F., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1712796 · Cited by 9

The Enrichment of Breast Cancer Stem Cells from MCF7 Breast Cancer Cell Line Using Spheroid Culture Technique

Ishtiah, A. A., & Yahaya, B. H. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1979-7_32 · Cited by 9

Modulation of Spheroid Forming Capacity and TRAIL Sensitivity by KLF4 and Nanog in Gastric Cancer Cells

To, H. T. N., Le, Q. A., Bui, H. T. T., Park, J., & Kang, D. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb45010018 · Cited by 9

Efficacious Combination Drug Treatment for Colorectal Cancer That Overcomes Resistance to KRAS G12C Inhibitors

Matsubara, H., Miyoshi, H., Kakizaki, F., Morimoto, T., Kawada, K., Yamamoto, T., Obama, K., Sakai, Y., & Taketo, M. M. (2023) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0411 · Cited by 9

The oncogenic role of LGR6 overexpression induced by aberrant Wnt/β‐catenin signaling in lung cancer

Sunaga, N., Kaira, K., Shimizu, K., Tanaka, I., Miura, Y., Nakazawa, S., Ohtaki, Y., Kawabata‐Iwakawa, R., Sato, M., Girard, L., et al. (2023) · Thoracic Cancer · doi:10.1111/1759-7714.15169 · Cited by 9

Strategies for the Isolation and Identification of Gastric Cancer Stem Cells

Wang, J., Qu, J., Hou, Q., Huo, X., Zhao, X., Chang, L., & Xu, C. (2024) · Stem Cells International · doi:10.1155/2024/5553852 · Cited by 9

Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers

Kim, J. H., Frantz, A. M., Sarver, A. L., Gorden, B. H., Lewellen, M., O’Brien, T. D., Dickerson, E. B., & Modiano, J. F. (2017) · Veterinary and Comparative Oncology · doi:10.1111/vco.12368 · Cited by 9

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

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