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Cited by 149Hormonal and reproductive studiesHypothalamic control of reproductive hormonesObesity, Physical Activity, Diet

Androgens before and after Weight Loss in Obese Children

Reinehr, Thomas, de Sousa, Gideon, Roth, Christian Ludwig, Andler, Werner·2005·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-0438
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Abstract

CONTEXT: Little information is available on androgens in obese children, and it is unknown whether these hormones change after weight loss. OBJECTIVE: The objective of this study was to compare androgens between obese and normal-weight children and to study the effect of weight loss on androgens. DESIGN: The design was a cross-sectional comparison between obese and normal-weight children separated according to pubertal stage and longitudinal 1-yr follow-up study in obese children participating in a weight-loss intervention. SETTING: The setting of this study was a primary care facility. PATIENTS: A total of 273 obese and 79 lean children (aged 4-14 yr) were studied, including a subgroup of 155 obese children for the longitudinal study. INTERVENTION: The intervention program was an outpatient 1-yr intervention program based on exercise, behavior, and nutrition therapy (high-carbohydrate low-fat diet). MAIN OUTCOME MEASURES: The outcome measures included testosterone and dehydroepiandrosterone sulfate (DHEAS) at baseline and 1 yr later. RESULTS: The obese prepubertal children and the obese pubertal girls showed significantly (P < 0.01) higher testosterone and DHEAS levels, whereas obese pubertal boys did not significantly differ in androgens from their lean counterparts. Significant correlations with body mass index were demonstrated in multivariate regression analyses for DHEAS in all children and for testosterone in prepubertal children and in pubertal girls. The obese prepubertal children and obese girls losing substantial weight showed a significant (P < 0.05) decrease in their testosterone concentrations. CONCLUSIONS: Moderately increased testosterone and DHEAS levels were found in obese prepubertal children and in obese pubertal girls, whereas androgen concentrations did not differ between obese and normal-weight pubertal boys. Weight loss induced a decrease in testosterone in obese prepubertal children and pubertal girls pointing to a reversible increase of androgens.

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Crossref · 10.1210/jc.2005-0438

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  • In a population-based Australian study of adolescents considered to have polycystic ovary syndrome, increased free testosterone concentration was the factor most predictive of insulin resistance, while menstrual irregularities and polycystic ovaries were not associated with insulin resistance.

    “a population-based study from Australia of adolescents considered to have PCOS in which increased free testosterone concentration was the factor most predictive of insulin resistance, while menstrual irregularities and polycystic ovaries were not associated with insulin resistance [127]”

    From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [127]

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Authors
Reinehr, T., de Sousa, G., Roth, C. L., & Andler, W.
Affiliations
  • Witten/Herdecke University (DE)
  • University of Bonn (DE)
Corresponding author
Reinehr, Thomas
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2005-10
Volume
90
Issue
10
Pages
5588-5595
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-0438
OpenAlex
W2053926560
Semantic Scholar
77e72a9fe61e227cfc6b39da8ea601ef87abb6c5
Cited by
149
References
38
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 13 · 2018: 11 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 7
FWCI
5.79
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
childhood obesity, androgens, testosterone, dehydroepiandrosterone sulfate, weight loss, puberty, sex differences, body mass index, prepubertal children
MeSH terms
Adolescent, Aging, Androgens, Body Weight, Child, Child, Preschool, Female, Humans, Male, Obesity, Puberty, Sex Characteristics, Testosterone, Weight Loss, Body Mass Index, Dehydroepiandrosterone Sulfate

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