ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis: M. tuberculosis kills host cells to spread cell-to-cell
Open accessAbstract
Apoptosis modulation is a procedure amply utilized by intracellular pathogens to favour the outcome of the infection. Nevertheless, the role of apoptosis during infection with Mycobacterium tuberculosis, the causative agent of human tuberculosis, is subject of an intense debate and still remains unclear. In this work, we describe that apoptosis induction in host cells is clearly restricted to virulent M. tuberculosis strains, and is associated with the capacity of the mycobacteria to secrete the 6 kDa early secreted antigenic target ESAT-6 bothunder in vitro and in vivo conditions. Remarkably, only apoptosis-inducing strains are able to propagate infection into new cells, suggesting that apoptosis is used by M. tuberculosis as a colonization mechanism. Finally, we demonstrate that in vitro modulation of apoptosis affects mycobacterial cell-to-cell spread capacity, establishing an unambiguous relationship between apoptosis and propagation of M. tuberculosis. Our data further indicate that BCG and MTBVAC vaccines are inefficient in inducing apoptosis and colonizing new cells, correlating with the strong attenuation profile of these strains previously observed in vitro and in vivo.
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The ESX-1 system is involved in bacterial phagosome-to-cytosol transition of M. tuberculosis and host cell death.
“The ESX-1 system was shown to be involved in bacterial phagosome-tocytosol transition of M. tuberculosis and host cell death (66)(67)(68), an important cell biological process that has numerous consequences for the host cell, such as induc-tion of the cGAS/STING/TBK1/IRF-3/type I interferon signalling axis and NLRP3 inflammasome activation (69)(70)(71)(72)(73)(74)(75).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [68]
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- Authors
- Aguilo, J. I., Alonso, H., Uranga, S., Marinova, D., Arbués, A., de Martino, A., Anel, A., Monzon, M., Badiola, J., Pardo, J., Brosch, R., & Martin, C.
- Affiliations
- Grupo de Genética de Micobacterias; Dpto. Microbiología, Medicina Preventiva y Salud Pública; Universidad de Zaragoza; C/ Domingo Miral s/n 50009 Zaragoza Spain
- Universidad de Zaragoza (ES)
- Unidad Anatomía Patológica; IIS Aragón Zaragoza Spain
- Research Centre for Encephalopathies and Transmissible Emerging Diseases; Universidad de Zaragoza; Zaragoza Spain
- Institut Pasteur (FR)
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2013-08-02
- Volume
- 15
- Issue
- 12
- Pages
- 1994-2005
- ISSN
- 1462-5814 (ISSN-L)
- OpenAlex
- W1576093496
- Cited by
- 140
- References
- 52
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 13 · 2022: 14 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 6 · 2017: 19 · 2016: 9 · 2015: 17 · 2014: 10 · 2013: 2
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cellular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Zaguan (Universidad de Zaragoza) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- Ministerio de Economía y Competitividad (SAF2011-25390)
- Ministerio de Ciencia e Innovación (SAF2011-25390)
- Universidad de Zaragoza
- Fundación Agencia Aragonesa para la Investigación y el Desarrollo
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- Mycobacterium tuberculosis, apoptosis, ESX-1, ESAT-6, cell-to-cell transmission, virulence, intracellular pathogens, BCG vaccine, bacterial colonization
- MeSH terms
- Animals, Antigens, Bacterial, Bacterial Proteins, BCG Vaccine, Female, Humans, Macrophages, Mice, Inbred C57BL, Mycobacterium tuberculosis, Tuberculosis, Apoptosis, Homeodomain Proteins, Green Fluorescent Proteins, Mice
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