The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

Queval, Christophe J.; Brosch, Roland; Simeone, Roxane

doi:10.3389/fmicb.2017.02284

Cited by 215Tuberculosis Research and EpidemiologyImmune responses and vaccinationsMycobacterium research and diagnosis

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

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Queval, Christophe J., Brosch, Roland, Simeone, Roxane·2017·Frontiers in Microbiology

DOI 10.3389/fmicb.2017.02284PMC PMC5703847

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Abstract

Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has plagued humans for thousands of years. TB still remains a major public health problem in our era, causing more than 4,400 deaths worldwide every day and killing more people than HIV. After inhaling Mtb-contaminated aerosols, TB primo-infection starts in the terminal lung airways, where Mtb is taken up by alveolar macrophages. Although macrophages are known as professional killers for pathogens, Mtb has adopted remarkable strategies to circumvent host defenses, building suitable conditions to survive and proliferate. Within macrophages, Mtb initially resides inside phagosomes, where its survival mostly depends on its ability to take control of phagosomal processing, through inhibition of phagolysosome biogenesis and acidification processes, and by progressively getting access to the cytosol. Bacterial access to the cytosolic space is determinant for specific immune responses and cell death programs, both required for the replication and the dissemination of Mtb. Comprehension of the molecular events governing Mtb survival within macrophages is fundamental for the improvement of vaccine-based and therapeutic strategies in order to help the host to better defend itself in the battle against the fierce invader Mtb. In this mini-review, we discuss recent research exploring how Mtb conquers and transforms the macrophage into a strategic base for its survival and dissemination as well as the associated defense strategies mounted by host.

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A number of secreted effectors, including EsxA (ESAT-6), EsxB (CFP-10), EspA, EspC, and PE/PPE proteins, have been suggested to intervene in host cellular and immune signaling pathways.
“Indeed, a number of secreted effectors, including EsxA (ESAT-6), EsxB (CFP-10), and ESX-1 secretion-associated proteins (Esp), such as EspA or EspC, as well as proteins that carry the characteristic N-terminal motifs Pro-Glu (PE) and Pro-Pro-Glu (PPE), have been suggested to intervene in host cellular and immune signaling pathways (11,24,25).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [25]
Mtb uses phagosomes of macrophages as a proliferative niche and inhibits fusion with lysosomes and avoids xenophagy.
“Like S.a., Mycobacterium tuberculosis (Mtb) uses phagosomes of macrophages as proliferative niche. Mechanisms to survive in phagosomes are the inhibition of fusion with lysosomes and avoiding to be targeted by xenophagy [255].”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [255]

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Authors: Queval, C. J., Brosch, R., & Simeone, R.
Affiliations: Institut Pasteur (FR)
ORCID: Brosch, Roland
Venue: Frontiers in Microbiology
Publisher: Frontiers Media SA
Published: 2017-11-23
Volume: 8
Pages: 2284-2284
ISSN: 1664-302X (ISSN-L)
DOI: 10.3389/fmicb.2017.02284
PMC: PMC5703847
OpenAlex: W2769733874
Cited by: 215
References: 132
Citations by year: 2026: 13 · 2025: 18 · 2024: 12 · 2023: 22 · 2022: 43 · 2021: 44 · 2020: 34 · 2019: 18 · 2018: 11
FWCI: 2.65
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: European Commission (ANR-10-LABX-62-IBEID, TBVAC2020, 643381)
Agence Nationale de la Recherche (10-LABX-62-IBEID, ANR‐10‐LABX‐62‐IBEID, ANR-16-CE15-0003, LABX-62-IBEID, ANR-14-JAMR-001-02, ANR-16, ANR-10, ANR-10-LABX, ANR-10-LABX-0062, TBVAC2020, ANR-14-JAMR-0001, ANR-10-LABX-62)
Fondation pour la Recherche Médicale (ANR-10-LABX-62-IBEID, DEQ20130326471)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: Mycobacterium tuberculosis, tuberculosis, alveolar macrophages, phagosome, phagolysosome biogenesis, phagosome acidification, bacterial dissemination, host-pathogen interaction

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The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

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