Improvements in health‐related quality of life with liraglutide 3.0 mg compared with placebo in weight management
Open accessAbstract
Summary: Obesity has a negative impact on health‐related quality of life (HRQoL). The SCALE Obesity and Prediabetes study investigated the effect of liraglutide 3.0 mg, as adjunct to diet and exercise, on HRQoL in patients with obesity [body mass index (BMI) ≥ 30 kg m−2] or overweight (BMI ≥ 27 kg m−2) with comorbidity. Participants were advised on a 500 kcal d−1 deficit diet and a 150‐min week−1 exercise programme and were randomised 2:1 to once‐daily subcutaneous liraglutide 3.0 mg or placebo. HRQoL was assessed using the Impact of Weight on Quality of Life‐Lite (IWQOL‐Lite) and Short‐Form 36 (SF‐36) v2 health questionnaires. Individuals on liraglutide 3.0 mg (n = 2046) had significantly greater improvements in IWQOL‐Lite total score (10.6 ± 13.3) vs. placebo (n = 1020) (7.7 ± 12.8) and SF‐36 physical (PCS) and mental (MCS) component summary scores (PCS, 3.6 ± 6.8; MCS, 0.2 ± 8.1) vs. placebo (PCS, 2.2 ± 7.7; MCS, −0.9 ± 9.1). The estimated treatment differences were IWQOL‐Lite total score 3.1 (95% CI: 2.2; 4.0), P < 0.0001; SF‐36 PCS 1.7 (95% CI: 1.2; 2.2), P < 0.0001 and MCS 0.9 (95% CI: 0.3; 1.5), P = 0.003. All subscales of the IWQOL‐Lite and SF‐36 were significantly improved with liraglutide 3.0 mg vs. placebo. More patients on liraglutide 3.0 mg experienced meaningful improvement on the IWQOL‐Lite total (P < 0.0001) and the SF‐36 PCS (P < 0.0001) scores.
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Weight reductions with lifestyle modification are associated in a generally linear manner with improvements in cardiovascular disease risk factors, quality of life, and prevention of type 2 diabetes.
“These reductions are associated in a generally linear manner with improvements in cardiovascular disease (CVD) risk factors, quality of life, and prevention of type 2 diabetes [24–26].”
From The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities (2023) · cites this paper as [25]
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- Authors
- Kolotkin, R. L., Fujioka, K., Wolden, M. L., Brett, J. H., & Bjorner, J. B.
- Affiliations
- Sykehuset i Vestfold (NO)
- Scripps Clinic (US)
- Novo Nordisk (Denmark) (DK)
- Novo Nordisk Inc. Plainsboro NJ USA
- Optum Patient Insights Lincoln RI USA
- Corresponding author
- Kolotkin, R. L.
- Venue
- Clinical Obesity
- Publisher
- Wiley
- Published
- 2016-05-19
- Volume
- 6
- Issue
- 4
- Pages
- 233-242
- ISSN
- 1758-8103 (ISSN-L)
- 1758-8111
- PMC
- PMC5084798
- OpenAlex
- W2474855670
- Cited by
- 40
- References
- 46
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 7 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Obesity (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nd)
- Funders
- Novo Nordisk (NCT01272219)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- liraglutide, obesity, weight management, health-related quality of life, GLP-1 receptor agonists, IWQOL-Lite, SF-36, diet and exercise, overweight, prediabetes, body mass index, adverse events, serious adverse events, hypoglycemia
- MeSH terms
- Liraglutide, Adolescent, Adult, Aged, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Quality of Life, Overweight, Young Adult
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