The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Role of pyroptosis in cardiovascular disease
Open accessAbstract
Cardiac function is determined by the dynamic equilibrium of various cell types and the extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially atherosclerosis and myocardial infarction, are often accompanied by cell death and acute/chronic inflammatory reactions. Caspase‐dependent pyroptosis is characterized by the activation of pathways leading to the activation of NOD‐like receptors, especially the NLRP3 inflammasome and its downstream effector inflammatory factors interleukin (IL)‐1β and IL‐18. Many studies in the past decade have investigated the role of pyroptosis in CVDs. The findings of these studies have led to the development of therapeutic approaches based on the regulation of pyroptosis, and some of these approaches are in clinical trials. This review summarizes the molecular mechanisms, regulation and cellular effects of pyroptosis briefly and then discusses the current pyroptosis studies in CVD research.
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Cited by
Malekmohammad, K., Bezsonov, E. E., & Rafieian-Kopaei, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.707529 · Cited by 346
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Programmed cell death in spinal cord injury pathogenesis and therapy
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Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway
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New perspective for pathomechanism and clinical applications of animal toxins: Programmed cell death
Sun, J., Liu, J., Liu, M., Bi, X., & Huang, C. (2024) · Toxicon · doi:10.1016/j.toxicon.2024.108071 · Cited by 6
Metadata
- Authors
- Zhaolin, Z., Guohua, L., Shiyuan, W., & Zuo, W.
- Venue
- Cell Proliferation
- Publisher
- Wiley
- Published
- 2018-12-07
- Volume
- 52
- Issue
- 2
- Pages
- e12563-e12563
- ISSN
- 0960-7722 (ISSN-L)
- 1365-2184
- OpenAlex
- W2904055459
- Cited by
- 493
- References
- 11
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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