The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans
Open accessAbstract
Glucose tolerance is lower at night and higher in the morning. Shift workers, who often eat at night and experience circadian misalignment (i.e. misalignment between the central circadian pacemaker and the environmental/behavioural cycles), have an increased risk of type 2 diabetes. To determine the separate and relative impacts of the circadian system, behavioural/environmental cycles, and their interaction (i.e. circadian misalignment) on insulin sensitivity and β‐cell function, the oral minimal model was used to quantitatively assess the major determinants of glucose control in 14 healthy adults using a randomized, cross‐over design with two 8‐day laboratory protocols. Both protocols involved 3 baseline inpatient days with habitual sleep/wake cycles, followed by 4 inpatient days with the same nocturnal bedtime (circadian alignment) or with 12‐hour inverted behavioural/environmental cycles (circadian misalignment). The data showed that circadian phase and circadian misalignment affect glucose tolerance through different mechanisms. While the circadian system reduces glucose tolerance in the biological evening compared to the biological morning mainly by decreasing both dynamic and static β‐cell responsivity, circadian misalignment reduced glucose tolerance mainly by lowering insulin sensitivity, not by affecting β‐cell function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Furthermore, it has been shown that such a decrease in insulin sensitivity is mostly caused by the behavioral cycle, while the circadian system dominates the deterioration in glucose tolerance and b-cell responsivity (8,32).”
From Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial (2022) · cites this paper as [32]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The circadian effect appeared to be independent of melatonin signaling, because melatonin levels were low during the circadian evening ($2000-2200 h) in the previous studies (8,32).”
From Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial (2022) · cites this paper as [32]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“longer sleep episodes correlate with an earlier intake of dinner/the last meal (83) as well as a decreased consumption of free sugars (173).”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [83]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Self-citationBuxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932
Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women
Pan, A., Schernhammer, E. S., Sun, Q., & Hu, F. B. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001141 · Cited by 805 · cited 1×
“The circadian regulation of β-cell function may provide an explanation for the increased risk of poor glycaemic control in late eaters and shift workers who often eat in the biological evening/night.(11,12) The results also support the findings that avoiding large meals with high glycaemic index in the late evening or…”
ResultCircadian misalignment increases cardiovascular disease risk factors in humans
Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516953113 · Cited by 691
Self-citationRoles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 632
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Van Cauter, E. (1997) · Endocrine Reviews · doi:10.1210/er.18.5.716 · Cited by 608
Leproult, R., Holmbäck, U., & Van Cauter, E. (2014) · Diabetes · doi:10.2337/db13-1546 · Cited by 607
Boden, G., Lebed, B., Schatz, M., Homko, C., & Lemieux, S. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1612 · Cited by 597
Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A., & Scheer, F. A. J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418955112 · Cited by 523
Self-citationRizza, R. A., Mandarino, L. J., & Gerich, J. E. (1982) · Diabetes · doi:10.2337/diab.31.8.663 · Cited by 440 · cited 1×
“decrease insulin sensitivity.(15,16) In the short-term circadian misalignment exposure (3 days), no evidence was found of altered β-cell function due to circadian misalignment.”
Background
Cited by
Sorted by citations
Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733
Self-citationCircadian disruption and human health
Fishbein, A. B., Knutson, K. L., & Zee, P. C. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148286 · Cited by 468
The circadian regulation of food intake
Challet, E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0210-x · Cited by 428
Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes
Mason, I. C., Qian, J., Adler, G. K., & Scheer, F. A. J. L. (2020) · Diabetologia · doi:10.1007/s00125-019-05059-6 · Cited by 359
Self-citationMelatonin effects on glucose metabolism: time to unlock the controversy
Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. A. J. L. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.11.011 · Cited by 193
Self-citation
Metadata
- Authors
- Qian, J., Dalla Man, C., Morris, C. J., Cobelli, C., & Scheer, F. A. J. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Department of Information Engineering University of Padova Padova Italy
- University of Padua (IT)
- Corresponding author
- Qian, Jingyi
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2018-07-02
- Volume
- 20
- Issue
- 10
- Pages
- 2481-2485
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- PMC
- PMC6167165
- OpenAlex
- W2807200695
- Cited by
- 170
- References
- 25
- Citations by year
- 2026: 25 · 2025: 11 · 2024: 19 · 2023: 30 · 2022: 19 · 2021: 15 · 2020: 38 · 2019: 10 · 2018: 3
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institutes of Health (R01HL094806, R01HL118601, R01DK099512, R01DK102696, R01DK105072)
- Harvard University
- Brigham and Women's Hospital (UL1RR025758)
- American Diabetes Association (#1‐17‐PDF‐103)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian misalignment, circadian system, insulin sensitivity, beta-cell function, insulin secretion, glucose tolerance, shift work, oral minimal model, type 2 diabetes risk, circadian phase
- MeSH terms
- Insulin Secretion, Adult, Blood Glucose, Circadian Rhythm, Clinical Protocols, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Insulin Resistance, Male, Glucose Intolerance, Cross-Over Studies, Chronobiology Disorders, Insulin-Secreting Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
