Weight loss induced by deep transcranial magnetic stimulation in obesity: A randomized, double-blind, sham-controlled study
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Aim: To test the hypothesis that deep transcranial magnetic stimulation (dTMS) reduces food craving and causes weight loss via neuromodulation. Materials and methods: This pilot study was designed as a randomized, double‐blind, sham‐controlled study. A total of 33 obese people (nine men, 24 women, mean age 48.1 ± 10.6 years, body mass index [BMI] 36.9 ± 4.7 kg/m 2 ) were randomized and completed the study: 13 participants underwent a 5‐week treatment with high‐frequency (HF) dTMS (18 Hz; HF group), 10 were treated with low‐frequency (LF) dTMS (1 Hz; LF group), and 10 were sham‐treated (sham group). Food craving, and metabolic and neuro‐endocrine variables were evaluated at baseline, after the 5‐week treatment, and at follow‐up visits (1 month, 6 months, 1 year after the end of treatment). Results: The mixed‐model analysis for repeated measures showed a significant interaction of time and groups for body weight ( P = 0.001) and BMI ( P = 0.001), with a significant body weight (−7.83 ± 2.28 kg; P = 0.0009) and BMI (−2.83 ± 0.83, P = 0.0009) decrease in the HF versus the sham group. A decreasing trend in food craving in the HF versus the LF and sham groups ( P = 0.073) was observed. A significant improvement of metabolic and physical activity variables was found ( P < 0.05) in the HF group. Conclusions: We demonstrated the safety and efficacy of dTMS, in addition to physical exercise and a hypocaloric diet, in reducing body weight for up to 1 year in obese people. We hypothesize that a possible mechanism of HF dTMS treatment is modulation of the dopaminergic pathway and stimulation of physical activity.
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Transcranial magnetic stimulation (TMS) modulates neuronal activity within circuits regulating feeding behavior and satiety.
“Beyond pharmacological and exercise-bases interventions, novel approaches such as transcranial magnetic stimulation (TMS), have been shown to modulate neuronal activity within circuits regulating feeding behavior and satiety (52).”
From GLP-1 agonists and exercise: the future of lifestyle prioritization (2025) · cites this paper as [52]
The Introduction says rTMS changes cortical excitability and dopamine release, and the Discussion links stimulation of the prefrontal cortex to control of feeding behaviour and reduced food cravings. The paper discusses brain pathways involved in homeostatic hunger, but does not show that TMS modulates neuronal activity in satiety-regulating circuits specifically. (LLM, conf=0.82)
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- Authors
- Ferrulli, A., Macrì, C., Terruzzi, I., Massarini, S., Ambrogi, F., Adamo, M., Milani, V., & Luzi, L.
- Affiliations
- IRCCS Policlinico San Donato (IT)
- University of Milan (IT)
- Corresponding author
- Luzi, Livio
- ORCID
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2019-05-15
- Volume
- 21
- Issue
- 8
- Pages
- 1849-1860
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W2935694069
- Cited by
- 45
- References
- 44
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 4
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Ministero della Salute
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- deep transcranial magnetic stimulation, obesity, weight loss, food cravings, high-frequency stimulation, low-frequency stimulation, neuromodulation, dopaminergic pathways, physical activity, hypocaloric diet, body mass index
- MeSH terms
- Adult, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Obesity, Pilot Projects, Weight Loss, Exercise, Treatment Outcome, Transcranial Magnetic Stimulation, Young Adult, Dopaminergic Neurons, Craving
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