Cited by 45Transcranial Magnetic Stimulation StudiesRegulation of Appetite and ObesityEating Disorders and Behaviors

Weight loss induced by deep transcranial magnetic stimulation in obesity: A randomized, double-blind, sham-controlled study

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Ferrulli, Anna, Macrì, Concetta, Terruzzi, Ileana, Massarini, Stefano, Ambrogi, Federico, Adamo, Michela, Milani, Valentina, Luzi, Livio·2019·Diabetes, Obesity and Metabolism

Abstract

Aim: To test the hypothesis that deep transcranial magnetic stimulation (dTMS) reduces food craving and causes weight loss via neuromodulation. Materials and methods: This pilot study was designed as a randomized, double‐blind, sham‐controlled study. A total of 33 obese people (nine men, 24 women, mean age 48.1 ± 10.6 years, body mass index [BMI] 36.9 ± 4.7 kg/m 2 ) were randomized and completed the study: 13 participants underwent a 5‐week treatment with high‐frequency (HF) dTMS (18 Hz; HF group), 10 were treated with low‐frequency (LF) dTMS (1 Hz; LF group), and 10 were sham‐treated (sham group). Food craving, and metabolic and neuro‐endocrine variables were evaluated at baseline, after the 5‐week treatment, and at follow‐up visits (1 month, 6 months, 1 year after the end of treatment). Results: The mixed‐model analysis for repeated measures showed a significant interaction of time and groups for body weight ( P = 0.001) and BMI ( P = 0.001), with a significant body weight (−7.83 ± 2.28 kg; P = 0.0009) and BMI (−2.83 ± 0.83, P = 0.0009) decrease in the HF versus the sham group. A decreasing trend in food craving in the HF versus the LF and sham groups ( P = 0.073) was observed. A significant improvement of metabolic and physical activity variables was found ( P < 0.05) in the HF group. Conclusions: We demonstrated the safety and efficacy of dTMS, in addition to physical exercise and a hypocaloric diet, in reducing body weight for up to 1 year in obese people. We hypothesize that a possible mechanism of HF dTMS treatment is modulation of the dopaminergic pathway and stimulation of physical activity.

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  • Transcranial magnetic stimulation (TMS) modulates neuronal activity within circuits regulating feeding behavior and satiety.

    “Beyond pharmacological and exercise-bases interventions, novel approaches such as transcranial magnetic stimulation (TMS), have been shown to modulate neuronal activity within circuits regulating feeding behavior and satiety (52).”

    From GLP-1 agonists and exercise: the future of lifestyle prioritization (2025) · cites this paper as [52]

    The Introduction says rTMS changes cortical excitability and dopamine release, and the Discussion links stimulation of the prefrontal cortex to control of feeding behaviour and reduced food cravings. The paper discusses brain pathways involved in homeostatic hunger, but does not show that TMS modulates neuronal activity in satiety-regulating circuits specifically. (LLM, conf=0.82)

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Research works printed but not linked: 1

  1. Gorman E, Hanson HM, Yang PH, Khan KM, Liu-Ambrose T, Ashe MC. Accelerometry analysis of physical activity and sedentary behavior in older adults: a systematic review and data analysis. Eur Rev Aging Phys Act 2014;11:35-49.

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Authors
Ferrulli, A., Macrì, C., Terruzzi, I., Massarini, S., Ambrogi, F., Adamo, M., Milani, V., & Luzi, L.
Affiliations
  • IRCCS Policlinico San Donato (IT)
  • University of Milan (IT)
Corresponding author
Luzi, Livio
Venue
Diabetes, Obesity and Metabolism
Publisher
Wiley
Published
2019-05-15
Volume
21
Issue
8
Pages
1849-1860
ISSN
  • 1462-8902 (ISSN-L)
  • 1463-1326
OpenAlex
W2935694069
Cited by
45
References
44
Citations by year
2026: 3 · 2025: 6 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 4
FWCI
2.20
Type
journal article
Language
en
Open access
Locations
  • Diabetes Obesity and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Funders
Ministero della Salute
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
deep transcranial magnetic stimulation, obesity, weight loss, food cravings, high-frequency stimulation, low-frequency stimulation, neuromodulation, dopaminergic pathways, physical activity, hypocaloric diet, body mass index
MeSH terms
Adult, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Obesity, Pilot Projects, Weight Loss, Exercise, Treatment Outcome, Transcranial Magnetic Stimulation, Young Adult, Dopaminergic Neurons, Craving

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