Relation of reward from food intake and anticipated food intake to obesity: A functional magnetic resonance imaging study.
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The authors tested the hypothesis that obese individuals experience greater reward from food consumption (consummatory food reward) and anticipated consumption (anticipatory food reward) than lean individuals using functional magnetic resonance imaging (fMRI) with 33 adolescent girls (mean age = 15.7, SD = 0.9). Obese relative to lean adolescent girls showed greater activation bilaterally in the gustatory cortex (anterior and mid insula, frontal operculum) and in somatosensory regions (parietal operculum and Rolandic operculum) in response to anticipated intake of chocolate milkshake (vs. a tasteless solution) and to actual consumption of milkshake (vs. a tasteless solution); these brain regions encode the sensory and hedonic aspects of food. However, obese relative to lean adolescent girls also showed decreased activation in the caudate nucleus in response to consumption of milkshake versus a tasteless solution, potentially because they have reduced dopamine receptor availability. Results suggest that individuals who show greater activation in the gustatory cortex and somatosensory regions in response to anticipation and consumption of food, but who show weaker activation in the striatum during food intake, may be at risk for overeating and consequent weight gain.
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In normal-weight controls, ACC and OFC activation during presentation of high-calorie food is negatively correlated with BMI.
“in normal-weight controls, the activation of the ACC and OFC (regions involved in salience attribution that project into the NAc) during presentation of high-calorie food was found to be negatively correlated with their BMI (91).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [91]
Obese individuals exhibit less activation of reward circuits from actual food consumption than lean individuals, but greater activation of somatosensory cortical regions that process palatability when anticipating consumption.
“obese individuals exhibited less activation of reward circuits from actual food consumption (consummatory food reward) than lean individuals, whereas they showed greater activation of somatosensory cortical regions that process palatability when they anticipated consumption (91).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [91]
Genetic and other social and biological variables may contribute to vulnerability to obesity and weight gain.
“genetic and other social and biological variables may also contribute towards vulnerability to obesity and weight gain”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Stice, Spoor, Bohon, Veldhuizen, & Small, 2008
Both addicted and obese subjects show less activation of reward circuits when given the drug or palatable food, respectively.
“Surprisingly, both addicted and obese subjects exhibit less activation of reward circuits when given the drug or the palatable food, respectively (45).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [45]
There is a considerable body of literature demonstrating differences in reward functions between lean and obese animals and humans.
“There is a considerable body of literature demonstrating differences in reward functions between lean and obese animals and humans ([40](#B40), [162](#B162), [173](#B173), [174](#B174)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [173]
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- Authors
- Stice, E., Spoor, S., Bohon, C., Veldhuizen, M. G., & Small, D. M.
- Affiliations
- Oregon Research Institute (US)
- Venue
- Journal of Abnormal Psychology
- Published
- 2008-11
- Volume
- 117
- Issue
- 4
- Pages
- 924-935
- ISSN
- 0021-843X (ISSN-L)
- 1939-1846
- PMC
- PMC2681092
- OpenAlex
- W2158287537
- Cited by
- 779
- References
- 72
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 25 · 2023: 20 · 2022: 43 · 2021: 46 · 2020: 38 · 2019: 39 · 2018: 75 · 2017: 69 · 2016: 58 · 2015: 57 · 2014: 62 · 2013: 51 · 2012: 77
- FWCI
- 29.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Abnormal Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R1MH64560A)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- food reward, obesity, gustatory cortex, insula, somatosensory cortex, caudate nucleus, adolescent girls, overeating, weight gain
- MeSH terms
- Adolescent, Appetite, Arousal, Brain Mapping, Cerebral Cortex, Corpus Striatum, Cues, Dominance, Cerebral, Eating, Female, Humans, Hunger, Magnetic Resonance Imaging, Motivation, Obesity, Reward, Taste, Body Mass Index
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