Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer
Open accessAbstract
Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimal despite its known efficacy in reducing recurrence and mortality. This study aims to investigate factors associated with non-adherence and inform the development of interventions to support women and promote adherence. A questionnaire survey to measure level of adherence, side effects experienced, beliefs about medicine, support received and socio-demographic details was sent to 292 women 2-4 years post breast cancer diagnosis. Differences between non-adherers and adherers to AET were explored, and factors associated with intentional and unintentional non-adherence are reported. Approximately one quarter of respondents, 46 (22%), were non-adherers, comprising 29 (14%) intentional non-adherers and 17 (8%) unintentional non-adherers. Factors significantly associated with intentional non-adherence were the presence of side effects (p < .03), greater concerns about AET (p < .001) and a lower perceived necessity to take AET (p < .001). Half of the sample (105/211) reported that side effects had a moderate or high impact on their quality of life. Factors associated with unintentional non-adherence were younger age (<65) (p < .001), post-secondary education (p = .046) and paid employment (p = .031). There are distinct differences between intentional non-adherence and unintentional non-adherence. Differentiation between the two types of non-adherence may help tailor support and advice interventions.
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Qualitative studies have highlighted a demand for accurate information about AET to overcome unfounded concerns.
“Qualitative studies have highlighted a demand for accurate information about AET to overcome unfounded concerns.27–29”
From Refining and optimising a behavioural intervention to support endocrine therapy adherence (ROSETA) in UK women with breast cancer: Protocol for a pilot fractional factorial trial (2023) · cites this paper as [29]
The Beliefs about medicine and impact on adherence section reports greater AET concerns among non-adherers, and the Conclusions recommend interventions to modify medication-related beliefs. But this paper describes a cross-sectional questionnaire survey, not a qualitative study, and it does not establish a demand for accurate information to overcome unfounded concerns. Page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredSeveral modifiable factors are associated with AET adherence, and four of the strongest determinants were selected as intervention targets.
“We identified several modifiable factors associated with AET adherence,27–30 selecting four of the strongest determinants as intervention targets.17”
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Cites
Reflective and Impulsive Determinants of Social Behavior
Strack, F., & Deutsch, R. (2004) · Personality and Social Psychology Review · doi:10.1207/s15327957pspr0803_1 · Cited by 3,984 · see citing works
A systematic review of the associations between dose regimens and medication compliance
Claxton, A. J., Cramer, J., & Pierce, C. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80109-0 · Cited by 2,388 · see citing works
Horne, R., & Weinman, J. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(99)00057-4 · Cited by 2,201 · see citing works
Davies, C., Pan, H., Godwin, J., Gray, R., Arriagada, R., Raina, V., Abraham, M., Alencar, V. H. M., Badran, A., Bonfill, X., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61963-1 · Cited by 2,044 · see citing works
Factors affecting therapeutic compliance: A review from the patient’s perspective
Li, S.-C. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s1458 · Cited by 1,266 · see citing works
A Systematic Review of Healthcare Applications for Smartphones
Mosa, A. S. M., Yoo, I., & Sheets, L. (2012) · BMC Medical Informatics and Decision Making · doi:10.1186/1472-6947-12-67 · Cited by 1,184 · see citing works
Horne, R., Chapman, S. C. E., Parham, R., Freemantle, N., Forbes, A., & Cooper, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080633 · Cited by 1,174 · see citing works
Reliability and validity of a new Medication Adherence Rating Scale (MARS) for the psychoses
Thompson, K. N., Kulkarni, J., & Sergejew, A. A. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00130-9 · Cited by 997 · see citing works
Hershman, D. L., Shao, T., Kushi, L. H., Buono, D., Tsai, W. Y., Fehrenbacher, L., Kwan, M., Gomez, S. L., & Neugut, A. I. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1132-4 · Cited by 870 · see citing works
Resisting medicines: a synthesis of qualitative studies of medicine taking
Pound, P., Britten, N., Morgan, M., Yardley, L., Pope, C., Daker-White, G., & Campbell, R. (2005) · Social Science & Medicine · doi:10.1016/j.socscimed.2004.11.063 · Cited by 868 · see citing works
Murphy, C. C., Bartholomew, L. K., Carpentier, M. Y., Bluethmann, S. M., & Vernon, S. W. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2114-5 · Cited by 708 · see citing works
Smartphone medication adherence apps: Potential benefits to patients and providers
Dayer, L. E., Heldenbrand, S. D., Anderson, P., Gubbins, P. O., & Martin, B. C. (2013) · Journal of the American Pharmacists Association · doi:10.1331/japha.2013.12202 · Cited by 474 · see citing works
Clifford, S., Barber, N., & Horne, R. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.05.004 · Cited by 384 · see citing works
McCowan, C., Shearer, J., Donnan, P. T., Dewar, J. A., Crilly, M., Thompson, A. M., & Fahey, T. P. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604758 · Cited by 343 · see citing works
Pandya, K. J., Morrow, G. R., Roscoe, J. A., Zhao, H., Hickok, J. T., Pajon, E. R., Sweeney, T. J., Banerjee, T. K., & Flynn, P. J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67215-7 · Cited by 332 · see citing works
Patient Nonadherence To Medication in Inflammatory Bowel Disease
Sewitch, M. J., Abrahamowicz, M., Barkun, A. N., Bitton, A., Wild, G., Cohen, A., & Dobkin, P. L. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07522.x · Cited by 327 · see citing works
Adjuvant Tamoxifen: Predictors of Use, Side Effects, and Discontinuation in Older Women
Demissie, S., Silliman, R. A., & Lash, T. L. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.2.322 · Cited by 301 · see citing works
Cohort study of adherence to adjuvant endocrine therapy, breast cancer recurrence and mortality
Makubate, B., Donnan, P. T., Dewar, J. A., Thompson, A. M., & McCowan, C. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.116 · Cited by 298 · see citing works
Cella, D., & Fallowfield, L. J. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9548-1 · Cited by 286 · cited 1× · see citing works
“AETs are known to have a significant side effect profile which can adversely affect quality of life and have previously been cited as barriers to continuing with treatment (Harrow et al, 2013; Morgan & Fenlon 2013; Fenlon et al, 2009; Cella & Fallowfield 2008).”
BackgroundFink, A. K., Gurwitz, J. H., Rakowski, W., Guadagnoli, E., & Silliman, R. A. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.11.064 · Cited by 282 · see citing works
Aikens, J. E. (2005) · The Annals of Family Medicine · doi:10.1370/afm.238 · Cited by 273 · see citing works
Adherence to adjuvant endocrine therapy in postmenopausal women with breast cancer
Ziller, V., Kalder, M., Albert, U., Holzhauer, W., Ziller, M., Wagner, U. A. G., & Hadji, P. (2009) · Annals of Oncology · doi:10.1093/annonc/mdn646 · Cited by 263 · see citing works
Adherence to endocrine therapy for breast cancer
Chlebowski, R. T., & Geller, M. L. (2006) · Oncology · doi:10.1159/000100444 · Cited by 251 · see citing works
Adherence beliefs among breast cancer patients taking tamoxifen
Grunfeld, E. A., Hunter, M. S., Sikka, P., & Mittal, S. (2004) · Patient Education and Counseling · doi:10.1016/j.pec.2004.10.005 · Cited by 245 · see citing works
Measuring Adherence in a Hypertension Clinical Trial
Hamilton, G. A. (2003) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(03)00058-6 · Cited by 144 · see citing works
Improving compliance and persistence to adjuvant tamoxifen and aromatase inhibitor therapy
Hadji, P. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.02.001 · Cited by 133 · see citing works
Conscientiousness and medication adherence: A meta-analysis
Molloy, G. J., O’Carroll, R. E., & Ferguson, E. (2014) · Annals of Behavioral Medicine · doi:10.1007/s12160-013-9524-4 · Cited by 130 · see citing works
Hadji, P., Blettner, M., Harbeck, N., Jackisch, C., Lück, H.-J., Windemuth-Kieselbach, C., Zaun, S., & Kreienberg, R. (2013) · Annals of Oncology · doi:10.1093/annonc/mds653 · Cited by 122 · cited 1× · see citing works
“While previous evidence has reported on factors affecting nonadherence to AET, such as side effects, concerns around toxicity and psycho- social factors (Cahir et al., 2015; Hadji et al., 2013; Harrow et al., 2013; Van Liew, Christensen, & de Moor, 2014), none have identified the extent to which behaviour is intention…”
BackgroundStanton, A. L., Petrie, K. J., & Partridge, A. H. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-2961-3 · Cited by 109 · see citing works
Bertelli, G., Venturini, M., Mastro, L. D., Bergaglio, M., Sismondi, P., Biglia, N., Venturini, S., Porcile, G., Pronzato, P., Costantini, M., et al. (2002) · Annals of Oncology · doi:10.1093/annonc/mdf151 · Cited by 98 · see citing works
Molloy, G. J., Messerli‐Bürgy, N., Hutton, G., Wikman, A., Perkins-Porras, L., & Steptoe, A. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.02.007 · Cited by 95 · see citing works
Archer, D. F., Dupont, C. M., Constantine, G. D., Pickar, J. H., & Olivier, S. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.10.057 · Cited by 91 · see citing works
Hormonal therapies for early breast cancer: systematic review and economic evaluation
Hind, D., Ward, S. E., Nigris, E. D., Simpson, E. L., Carroll, C., & Wyld, L. (2007) · Health Technology Assessment · doi:10.3310/hta11260 · Cited by 85 · see citing works
Adherence to adjuvant therapy in post-menopausal breast cancer patients: a review
Banning, M. (2011) · European Journal of Cancer Care · doi:10.1111/j.1365-2354.2011.01295.x · Cited by 83 · see citing works
Harrow, A., Dryden, R., McCowan, C., Radley, A., Parsons, M., Thompson, A. M., & Wells, M. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005285 · Cited by 83 · see citing works
Pellegrini, I., Sarradon‐Eck, A., Soussan, P. B., Lacour, A., Largillier, R., Tallet, A. R., Tarpin, C., & Julian‐Reynier, C. (2009) · Psycho-Oncology · doi:10.1002/pon.1593 · Cited by 82 · see citing works
Adherence to long-term adjuvant hormonal therapy for breast cancer
Gotay, C. C., & Dunn, J. (2011) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/erp.11.80 · Cited by 64 · see citing works
Liew, J. R., Christensen, A. J., & de Moor, J. S. (2014) · Journal of Cancer Survivorship · doi:10.1007/s11764-014-0374-2 · Cited by 59 · see citing works
Cahir, C., Dombrowski, S. U., Kelly, C. M., Kennedy, M. J., Bennett, K., & Sharp, L. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-2685-x · Cited by 58 · see citing works
Omran, D., Guirguis, L. M., & Simpson, S. H. (2012) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2012.07.002 · Cited by 52 · see citing works
Güth, U., Myrick, M. E., Schötzau, A., Kilic, N., & Schmid, S. M. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1668-y · Cited by 49 · see citing works
Evaluating adherence to medication in children and adolescents with HIV
Khan, M. U., Song, X., Williams, K., Bright, K., Sill, A. M., & Rakhmanina, N. Y. (2009) · Archives of Disease in Childhood · doi:10.1136/adc.2008.156232 · Cited by 47 · see citing works
Delea, T. E., Karnon, J. D., Smith, R. E., Johnston, S. R. D., Brandman, J., Sung, J., & Gross, P. E. (2006) · PubMed · Cited by 42 · see citing works
Menopausal hot flushes after breast cancer
Fenlon, D., Corner, J. L., & Haviland, J. (2009) · European Journal of Cancer Care · doi:10.1111/j.1365-2354.2007.00902.x · Cited by 36 · see citing works
Self-citationVerbrugghe, M., Verhaeghe, S. T. L., Decoene, E., Baere, S. D., Vandendorpe, B., & Hecke, A. V. (2015) · European Journal of Cancer Care · doi:10.1111/ecc.12339 · Cited by 32 · see citing works
Fenlon, D., Powers, C., Simmonds, P., CLOUGH, J. B., & Addington-Hall, J. M. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-467 · Cited by 32 · see citing works
Self-citationEffects of Acupuncture on Menopause-Related Symptoms in Breast Cancer Survivors
Chiu, H.-Y., Shyu, Y., Chang, P., & Tsai, P.-S. (2015) · Cancer Nursing · doi:10.1097/ncc.0000000000000278 · Cited by 30 · see citing works
Wouters, H., van Geffen, E. C. G., Baas-Thijssen, M. C. M., Krol-Warmerdam, E. M., Stiggelbout, A. M., Belitser, S. V., Bouvy, M. L., & van Dijk, L. (2013) · The Breast · doi:10.1016/j.breast.2013.05.005 · Cited by 26 · see citing works
“Keeping the Boogie Man Away”: Medication Self-Management among Women Receiving Anastrozole Therapy
Wickersham, K. E., Happ, M. B., & Bender, C. M. (2012) · Nursing Research and Practice · doi:10.1155/2012/462121 · Cited by 18 · see citing works
Women's Experiences With Antiestrogen Therapy to Treat Breast Cancer
Flanagan, J. M., Winters, L. N., Habin, K. R., & Cashavelly, B. J. (2011) · Oncology nursing forum · doi:10.1188/12.onf.70-77 · Cited by 11 · see citing works
Yang, J. J., Park, S. K., Cho, L. Y., Han, W., Park, B., Kim, H., Lee, K.-S., Hahn, S., Cho, S., Ahn, S., et al. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2010.05.013 · Cited by 9 · see citing works
Is It Me Or Is It Hot In Here? A Plea For More Research Into Hot Flushes
Morgan, A. A., & Fenlon, D. (2013) · Clinical Oncology · doi:10.1016/j.clon.2013.07.008 · Cited by 7 · see citing works
Self-citationAn economic evaluation of the use of tamoxifen in the treatment of early breast cancerPreprint
Glasziou, P., & Haas, M. R. (1994) · RePEc: Research Papers in Economics · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Ingersoll K.S., Cohen J. (2008) The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behav Med. 31(3), 213-224
- McCowan C., Wang S., Thompson A., Makubate B., Petrie D. (2013) The value of high adherence to tamoxifen in women with breast cancer: A community-based cohort study. British Journal of Cancer 109, 1172-1180
- Brett, J., Fenlon, D., Boulton, M., Hulbert-Williams, N. J., Walter, F. M., Donnelly, P., Lavery, B., Morgan, A., Morris, C. & Watson, E. (2018). Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer. EUROPEAN JOURNAL OF CANCER CARE, 27 (1), https://doi.org/10.1111/ecc.12601. Persistent Link: http://hdl.handle.net/11343/292177
Cited by
Sorted by citations
Lambert, L. K., Balneaves, L. G., Howard, A. F., & Gotay, C. C. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4561-5 · Cited by 126 · see citing works
Endocrine Therapy Nonadherence and Discontinuation in Black and White Women
Wheeler, S. B., Spencer, J. C., Pinheiro, L. C., Murphy, C. C., Earp, J. A., Carey, L., Olshan, A. F., Tse, C. K., Bell, M. B., Weinberger, M., et al. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy136 · Cited by 103 · see citing works
Identifying adherence barriers to oral endocrine therapy among breast cancer survivors
Paranjpe, R., John, G., Trivedi, M. V., & Abughosh, S. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-05073-z · Cited by 96 · see citing works
Nonadherence to tamoxifen in breast cancer survivors: A 12 month longitudinal analysis.
Moon, Z., Moss-Morris, R. E., Hunter, M. S., Norton, S., & Hughes, L. D. (2019) · Health Psychology · doi:10.1037/hea0000785 · Cited by 92 · see citing works
Toivonen, K., Williamson, T., Carlson, L., Walker, L., & Campbell, T. (2020) · Cancers · doi:10.3390/cancers13010107 · Cited by 77 · see citing works
Acceptability and feasibility of a self-management intervention for women prescribed tamoxifen
Moon, Z., Moss-Morris, R. E., Hunter, M. S., Goodliffe, S., & Hughes, L. D. (2019) · Health Education Journal · doi:10.1177/0017896919853856 · Cited by 66 · see citing works
Moore, H. C. F. (2020) · Seminars in Oncology · doi:10.1053/j.seminoncol.2020.05.004 · Cited by 64 · see citing works
Brett, J., Boulton, M. G., Fenlon, D., Hulbert-Williams, N., Walter, F. M., Donnelly, P., Lavery, B. A., Morgan, A. A., Morris, C., & Watson, E. K. (2018) · Patient Preference and Adherence · doi:10.2147/ppa.s145784 · Cited by 63 · see citing works
Self-citationAdherence to Adjuvant Endocrine Therapy in Breast Cancer Patients
Rosso, R., D’Alonzo, M., Bounous, V. E., Actis, S., Cipullo, I., Salerno, E., & Biglia, N. (2023) · Current Oncology · doi:10.3390/curroncol30020112 · Cited by 57 · see citing works
Buszek, S. M., Lin, H. Y., Bedrosian, I., Tamirisa, N., Babiera, G. V., Shen, Y., & Shaitelman, S. F. (2019) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2019.07.052 · Cited by 55 · see citing works
Fleming, L., Agnew, S., Peddie, N., Crawford, M., Dixon, D. L., & Macpherson, I. R. (2022) · The Breast · doi:10.1016/j.breast.2022.04.010 · Cited by 50 · see citing works
Özlü, B., Kabay, G., Bocek, I., Yılmaz, M., Pişkin, A. K., Shim, B. S., & Mutlu, M. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118613 · Cited by 46 · see citing works
Moon, Z., Moss-Morris, R. E., Hunter, M. S., & Hughes, L. D. (2017) · British Journal of Health Psychology · doi:10.1111/bjhp.12274 · Cited by 43 · see citing works
Factors Associated with Endocrine Therapy Non‐Adherence in Breast Cancer Survivors
Spencer, J. C., Reeve, B. B., Troester, M. A., & Wheeler, S. B. (2020) · Psycho-Oncology · doi:10.1002/pon.5289 · Cited by 43 · see citing works
The role of the pharmacist in improving medication beliefs and adherence in cancer patients
Birand, N., Boşnak, A. S., Diker, Ö., Abdi, A. M., & Başgut, B. (2019) · Journal of Oncology Pharmacy Practice · doi:10.1177/1078155219831377 · Cited by 42 · see citing works
Adherence to Treatment in Patients with Chronic Diseases: From Alertness to Persistence.
Danielson, E., Melin‐Johansson, C., & Modanloo, M. (2019) · PubMed Central · doi:10.30476/ijcbnm.2019.81303.0 · Cited by 37 · see citing works
Singleton, A. C., Raeside, R., Partridge, S. R., Hayes, M., Maka, K., Hyun, K. K., Thiagalingam, A., Chow, C. K., Sherman, K. A., Elder, E. E., et al. (2021) · Journal of Medical Internet Research · doi:10.2196/27076 · Cited by 37 · see citing works
The prevalence and predictors of using herbal medicines among Iranian cancer patients
Bazrafshani, M. S., Khandani, B. K., Pardakhty, A., Tajadini, H., Afshar, R. M., Moazed, V., Nemati, A., Nasiri, N., & Sharifi, H. (2019) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2019.03.009 · Cited by 36 · see citing works
Xu, H., Jin, F., Zhang, X., Wang, D., Yu, S., & Wang, A. (2020) · Cancer Medicine · doi:10.1002/cam4.3017 · Cited by 34 · see citing works
Green, S. M. C., French, D., Graham, C. D., Hall, L., Rousseau, N. S., Foy, R., Clark, J., Parbutt, C., Raine, E., Gardner, B., et al. (2022) · BMC Health Services Research · doi:10.1186/s12913-022-08243-4 · Cited by 31 · see citing works
Smith, K. L., Verma, N., Blackford, A. L., Lehman, J., Westbrook, K. E., Lim, D., Fetting, J. H., Wolff, A. C., Jelovac, D., Miller, R. S., et al. (2022) · npj Breast Cancer · doi:10.1038/s41523-022-00414-0 · Cited by 30 · see citing works
Zhao, M., Zhao, J., Chen, J., Li, M., Zhang, L., Luo, X., Zhang, Y., Xiong, C., Guo, Z., & Yan, J. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07411-w · Cited by 27 · see citing works
Brett, J., Boulton, M. G., & Watson, E. K. (2018) · Patient Preference and Adherence · doi:10.2147/ppa.s187692 · Cited by 24 · see citing works
Self-citationSurvivorship care for postmenopausal breast cancer patients in Ireland: What do women want ?
Meade, E., McIlfatrick, S., Groarke, A., Butler, E., & Dowling, M. (2017) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2017.03.003 · Cited by 24 · see citing works
Moon, Z., Moss-Morris, R. E., Hunter, M. S., & Hughes, L. D. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05850-x · Cited by 22 · see citing works
Yusufov, M., Nathan, M., Wiley, A., Russell, J. A., Partridge, A. H., & Joffe, H. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05920-y · Cited by 21 · see citing works
Smith, S. G., Green, S. M. C., Ellison, R., Foy, R., Graham, C. D., Mason, E., French, D. P., Hall, L. H., Wilkes, H., McNaught, E., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-069971 · Cited by 20 · see citing works
Xu, H., Zhang, X., Wang, D., Xu, L., & Wang, A. (2019) · Journal of Advanced Nursing · doi:10.1111/jan.14253 · Cited by 20 · see citing works
“It is not just any pill”—Women’s experiences of endocrine therapy after breast cancer surgery
Karlsson, S. A., Wallengren, C., Bagge, R. O., & Henoch, I. (2019) · European Journal of Cancer Care · doi:10.1111/ecc.13009 · Cited by 17 · see citing works
Relationships between determinants of adjuvant endocrine therapy adherence in breast cancer
Lee, J. Y., & Min, Y. H. (2018) · BMC Women s Health · doi:10.1186/s12905-018-0522-3 · Cited by 17 · see citing works
Moore, L., Matheson, L., Brett, J., Lavender, V., Kendall, A., Lavery, B. A., & Watson, E. K. (2022) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2022.102183 · Cited by 16 · see citing works
Self-citationUhelski, A.-C. R., Blackford, A. L., Sheng, J. Y.-S., Snyder, C. F., Lehman, J., Visvanathan, K., Lim, D., Stearns, V., & Smith, K. L. (2023) · Journal of Cancer Survivorship · doi:10.1007/s11764-023-01408-y · Cited by 15 · see citing works
Yang, S., Park, S. W., Bae, S. J., Ahn, S. G., Jeong, J., & Park, K. (2023) · Journal of Breast Cancer · doi:10.4048/jbc.2023.26.e22 · Cited by 15 · see citing works
The impact of symptom clusters on endocrine therapy adherence in patients with breast cancer
Agnew, S., Crawford, M., Macpherson, I. R., Shiramizu, V. K. M., & Fleming, L. (2024) · The Breast · doi:10.1016/j.breast.2024.103731 · Cited by 15 · see citing works
Dahn, H., Wilke, D., WALSH, G. W., & Pignol, J. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05691-6 · Cited by 15 · see citing works
How Medic–Patient Communication and Relationship Influence Chinese Patients’ Treatment Adherence
Zhong, Z., Nie, J., Xie, X., & Liu, K. (2018) · Journal of Health Communication · doi:10.1080/10810730.2018.1561768 · Cited by 15 · see citing works
Smith, K. L., Tsai, H., Lim, D., Wang, C., Nunes, R., Wilkinson, M. J., Sheng, J. Y.-S., Couzi, R. J., Fetting, J. H., Riley, C. D., et al. (2023) · JCO Oncology Practice · doi:10.1200/op.23.00038 · Cited by 14 · see citing works
Sutton, A. L., Salgado, T. M., He, J., Hurtado‐de‐Mendoza, A., & Sheppard, V. B. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-019-05247-5 · Cited by 14 · see citing works
Meattini, I., Franco, R. C. D. O., Salvestrini, V., & Hijal, T. (2023) · The Breast · doi:10.1016/j.breast.2023.04.007 · Cited by 13 · see citing works
Sung, S., Min, Y. H., Park, S. K., & Lee, S. B. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.844926 · Cited by 12 · see citing works
Hefner, J., Berberich, S., Lanvers, E., Sanning, M., Steimer, A.-K., & Kunzmann, V. (2018) · Patient Preference and Adherence · doi:10.2147/ppa.s169354 · Cited by 12 · see citing works
“I Made All Decisions Myself”: Breast Cancer Treatment Decision-Making by Receivers and Decliners
Kim, E.-J., Jang, S. H., Andersen, M. R., & Standish, L. J. (2021) · Asia-Pacific Journal of Oncology Nursing · doi:10.4103/2347-5625.311952 · Cited by 11 · see citing works
Mohammed, S. I., Sabry, A. T., & Sabry, D. T. (2021) · Iraqi Journal of Pharmaceutical Sciences · doi:10.31351/vol30iss2pp113-121 · Cited by 11 · see citing works
McGuinness, S., Hughes, L. D., Moss-Morris, R. E., Hunter, M. S., Norton, S., & Moon, Z. (2022) · European Journal of Cancer Care · doi:10.1111/ecc.13722 · Cited by 11 · see citing works
Janssen, A. M., Dam, J., Prins, J. B., Buffart, L. M., & de Bruin, M. (2022) · European Journal of Cancer Care · doi:10.1111/ecc.13721 · Cited by 10 · see citing works
Compliance to adjuvant endocrine therapy and survival in breast cancer patients.
Chamalidou, C., Nasic, S., & Linderholm, B. K. (2023) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2023.100704 · Cited by 10 · see citing works
Green, S. M. C., Hall, L., French, D., Rousseau, N. S., Parbutt, C., Walwyn, R. E. A., & Smith, S. G. (2023) · Annals of Behavioral Medicine · doi:10.1093/abm/kaad037 · Cited by 10 · see citing works
Ucciero, S., Lacarbonara, F., Durante, Á., Torino, F., Uchmanowicz, I., Vellone, E., & Nitto, M. D. (2024) · PLoS ONE · doi:10.1371/journal.pone.0307838 · Cited by 10 · see citing works
Huiskes, V. J. B., van den Ende, C. H. M., van Dijk, L., Burger, D. M., & van den Bemt, B. J. F. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14467 · Cited by 10 · see citing works
Endocrine Treatment-Related Symptoms and Patient Outcomes in Breast Cancer: A Meta-Analysis
Yoo, T.-K. R., Jang, M., Lee, E.-S., Moon, H., Noh, D., & Han, W. (2018) · Journal of Breast Cancer · doi:10.4048/jbc.2018.21.1.37 · Cited by 10 · see citing works
Saad, A. H., Rabeea, I. S., & Salih, H. (2022) · Iraqi Journal of Pharmaceutical Sciences · doi:10.31351/vol30isssuppl.pp31-39 · Cited by 9 · see citing works
Marston, M. T., Berben, L., Dobbels, F., Russell, C. L., & Geest, S. D. (2023) · Transplant International · doi:10.3389/ti.2023.11308 · Cited by 9 · see citing works
Wreyford, L., Gururajan, R., & Zhou, X. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282180 · Cited by 8 · see citing works
Wang, X., Jia, R., Xiang, G., Zhang, D., Wang, Y., & Xu, H. (2025) · Health Science Reports · doi:10.1002/hsr2.70934 · Cited by 8 · see citing works
The Mediating Role of Spiritual Health in Adherence to Treatment in Patients with Cancer
Farahani, A. S., Ashrafizadeh, H., Akbari, M. E., Motefakker, S., Khademi, F., Ebrahimloee, S., Karami, M., Shahrbabaki, R. M., Razmara, R., Abreu, W., et al. (2022) · International Journal of Cancer Management · doi:10.5812/ijcm-127820 · Cited by 8 · see citing works
Recent advances in de-intensification of radiotherapy in elderly cancer patients
Desideri, I., Salvestrini, V., & Livi, L. (2020) · F1000Research · doi:10.12688/f1000research.21151.1 · Cited by 8 · see citing works
Roberson, P. N. E., Tasman, J. G., Cortez, G., Lenger, K. A., & Lloyd, J. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111213 · Cited by 7 · see citing works
Adherence to oral hormonal anticancer agents in breast cancer
Gori, S., Modena, A., Foglietta, J., Verzè, M., Inno, A., Casarin, A., Russo, A. D., & Nicolis, F. (2022) · Tumori Journal · doi:10.1177/03008916221096183 · Cited by 7 · see citing works
Eraso, Y. (2019) · Patient Preference and Adherence · doi:10.2147/ppa.s211939 · Cited by 7 · see citing works
Ivory, J. M., Wheeler, S. B., Drier, S., Gunn, H. J., Zahrieh, D. M., Paskett, E. D., Naughton, M. J., Wills, R., Swetel, K., Chow, S. L.-M., et al. (2023) · Trials · doi:10.1186/s13063-023-07672-8 · Cited by 6 · see citing works
Understanding pain related to adjuvant endocrine therapy after breast cancer: A qualitative report
Walsh, E. A., Chabria, R. S., Vranceanu, A., Park, E. R., Post, K. E., Peppercorn, J. M., Temel, J. S., Greer, J. A., & Jacobs, J. M. (2022) · European Journal of Cancer Care · doi:10.1111/ecc.13723 · Cited by 6 · see citing works
Park, S. K., & Min, Y. H. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1170077 · Cited by 6 · see citing works
Green, S. M. C., Hall, L., Rousseau, N. S., French, D., Graham, C. D., Collinson, M., Mason, E. D., Wilkes, H., Howdon, D., Foy, R., et al. (2023) · NIHR Open Research · doi:10.3310/nihropenres.13337.2 · Cited by 6 · see citing works
Use of Adjuvant Endocrine Therapy Among Post-Menopausal Breast Cancer Patients in Malaysia
Bahri, A. S., Mahmood, T. M. T., Aziz, S. A. A., Makmor‐Bakry, M., & Shah, N. M. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s293029 · Cited by 6 · see citing works
Signorelli, J., Tran, T. B., Sirek, M. E., Díaz-Rohena, Y., Taraba, J. L., Muluneh, B., Basu, N., Lilly, J., & Darling, J. O. (2023) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552231208442 · Cited by 5 · see citing works
Cabling, M. L., Drago, F., Turner, J. W., Hurtado‐de‐Mendoza, A., & Sheppard, V. B. (2022) · Health and Technology · doi:10.1007/s12553-022-00707-1 · Cited by 5 · see citing works
Green, S. M. C., Smith, S. G., Collins, L. M., & Strayhorn, J. C. (2024) · Translational Behavioral Medicine · doi:10.1093/tbm/ibae029 · Cited by 5 · see citing works
Weight gain after breast cancer diagnosis: It's complicated…
Cathcart-Rake, E. J., Sanft, T. B., & Tevaarwerk, A. J. (2022) · Cancer · doi:10.1002/cncr.34343 · Cited by 5 · see citing works
Okroša, A. D., Silovski, T., Plavetić, N. D., Silovski, H., Kovačić, A., & Mucalo, I. (2023) · Acta Pharmaceutica · doi:10.2478/acph-2023-0043 · Cited by 4 · see citing works
Receiving/declining adjuvant breast cancer treatments and involvement in treatment decision-making
Kim, E.-J., Andersen, M. R., & Standish, L. J. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.01.012 · Cited by 4 · see citing works
Lesur, A., Dalenc, F., & Beguignot, M. (2019) · Bulletin du Cancer · doi:10.1016/s0007-4551(20)30045-x · Cited by 4 · see citing works
Manoliu-Hamwi, E.-M., Dascălu, C. G., Ghiciuc, C. M., Zegan, G., Cărăușu, E. M., Moscu, M., & Stan, C. D. (2024) · Journal of Pharmaceutical Policy and Practice · doi:10.1080/20523211.2024.2438235 · Cited by 3 · see citing works
Lau, C., LaBorde, K., Fatima, B., Alfartosy, S. S., Abughosh, S., Torre, R. M. D. L., Brown, E. N., & Trivedi, M. V. (2025) · Breast Cancer Research and Treatment · doi:10.1007/s10549-025-07701-x · Cited by 3 · see citing works
Initiation of Oral Endocrine Therapy and Survival Benefit Among Women with Early-Stage Breast Cancer
Qian, J., & Truong, B. (2024) · Journal of Women s Health · doi:10.1089/jwh.2023.0971 · Cited by 3 · see citing works
Ream, M. E., Taub, C. J., Amonoo, H. L., Walsh, E. A., Popok, P., Plotke, R. L., Jacobs, J. M., Gudenkauf, L. M., Penedo, F. J., O’Neil, D. S., et al. (2025) · Psycho-Oncology · doi:10.1002/pon.70267 · Cited by 2 · see citing works
Rattsev, I., Stearns, V., Blackford, A. L., Hertz, D. L., Smith, K. L., Rae, J. M., & Taylor, C. O. (2024) · JAMIA Open · doi:10.1093/jamiaopen/ooae006 · Cited by 1 · see citing works
Cocozza, T., Smith, R. M., López, A. M., Rudoler, S. B., Slamon, R., Zhan, T., Vega, J. L., Dhamankar, M., Padmanabhan, A., Miller, S. M., et al. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22050734 · Cited by 1 · see citing works
Dehesh, P., Kalantari-Khandani, B., Momeni, M., Danaei, M., & Gughari, F. S. (2026) · Iranian Journal of Breast Diseases · doi:10.66224/ijbd.18.4.24 · Cited by 1 · see citing works
Okroša, A. D., Silovski, T., Plavetić, N. D., Kifer, D., Budisavljević, A., Silovski, H., Perišin, A. Š., Kelemenić-Dražin, R., Skelin, M., Bručić, L. J., et al. (2026) · British Journal of Clinical Pharmacology · doi:10.1002/bcp.70514 · Cited by 1 · see citing works
Bonzano, E., & Meattini, I. (2022) · Springer eBooks · doi:10.1007/978-3-030-91170-6_45 · Cited by 1 · see citing works
Conditional adherence after medical recommendation and the attraction of additional information
Turja, T., Jylhä, V., Rosenlund, M., & Kuusisto, H. (2025) · Patient Education and Counseling · doi:10.1016/j.pec.2025.108683 · Cited by 1 · see citing works
Kim, E., Standish, L. J., & Andersen, M. R. (2019) · Edelweiss Cancer Open Access · doi:10.33805/2689-6737.108
Salvestrini, V., Mariotti, M., Banini, M., Becherini, C., Visani, L., Scotti, V., Desideri, I., Livi, L., & Meattini, I. (2021) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2021.1897463
Green, S. M. C., Hall, L., Rousseau, N., et al. (2023) · Research Open (London South Bank University) · doi:10.3310/nihropenres.14463.r29031
Green, S. M. C., Hall, L., Rousseau, N., et al. (2023) · NIHR Open Research · doi:10.3310/nihropenres.14463.r28987
Green, S. M. C., Hall, L., Rousseau, N., et al. (2023) · Research Open (London South Bank University) · doi:10.3310/nihropenres.14552.r29196
Green, S. M. C., Hall, L., Rousseau, N., et al. (2023) · NIHR Open Research · doi:10.3310/nihropenres.14552.r29195
Subjective Rationalities of Nonadherence to Treatment and Vaccination in Healthcare Decision-Making
Turja, T., Rosenlund, M., & Kuusisto, H. (2024) · Patient Preference and Adherence · doi:10.2147/ppa.s454661
Budaycı, Ö., & Özkan, S. (2025) · Pamukkale Medical Journal · doi:10.31362/patd.1621040
Guillier, A., Dalenc, F., Lamy, S., Cousseau, L., & Vaysse, C. (2025) · Gynécologie Obstétrique Fertilité & Sénologie · doi:10.1016/j.gofs.2025.06.010
Living well after organ transplantation
(2025) · Frontiers Media SA eBooks · doi:10.3389/978-2-8325-6921-4
Križić, M., Silovski, T., Hoste, G., Plavetić, N. D., Romano, O., González, X., Jimenez, A. C., Zotano, Á. G., Suissa, J., Beghdad, F., et al. (2025) · Oncology and Therapy · doi:10.1007/s40487-025-00392-w
Green, S. M. C., French, D., Graham, C. D., Hall, L., Rousseau, N., Foy, R., Clark, J., Parbutt, C., Raine, E., Gardner, B., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20619870
Green, S. M. C., French, D., Graham, C. D., Hall, L., Rousseau, N., Foy, R., Clark, J., Parbutt, C., Raine, E., Gardner, B., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20619867
Green, S. M. C., French, D., Graham, C. D., Hall, L., Rousseau, N., Foy, R., Clark, J., Parbutt, C., Raine, E., Gardner, B., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20619876
Ruggeri, S. Y., Lippincott, C. L. R., Alexander, G. L., Ellis, R. J. B., Chesnut, S. R., & Erickson, L. A. (2026) · Cancer Medicine · doi:10.1002/cam4.71925
Noreen, D., Shakeel, S., Rahim, N., Shamim, S., Anjum, F., Zehra, A., Haider, G., & Ahmed, A. S. (2026) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2026.27.6.2225
Poor adherence to cancer therapy in Ethiopia: systematic review and meta-analysis
Baye, A. A., Abere, Y., Kefale, D., Eshetie, Y., Ewunetu, M., Bazezew, L. Y., Yirga, G. K., & Mekonnen, G. B. (2026) · Public health reviews · doi:10.3389/phrs.2026.1608819
- Authors
- Brett, J., Fenlon, D., Boulton, M., Hulbert-Williams, N. J., Walter, F. M., Donnelly, P., Lavery, B., Morgan, A., Morris, C., & Watson, E.
- Affiliations
- Oxford Brookes University (GB)
- University of Southampton (GB)
- University of Chester (GB)
- University of Cambridge (GB)
- Torbay Hospital (GB)
- University of Oxford (GB)
- Independent Cancer Patient Voice; London UK
- Corresponding author
- Brett, J.
- Venue
- European Journal of Cancer Care
- Publisher
- Wiley
- Published
- 2016-11-30
- Volume
- 27
- Issue
- 1
- Pages
- e12601
- ISSN
- 0961-5423 (ISSN-L)
- OpenAlex
- W2537847296
- Cited by
- 98
- References
- 54
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 21 · 2022: 19 · 2021: 5 · 2020: 10 · 2019: 13 · 2018: 8 · 2017: 3
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Cancer Care (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- ChesterRep (University of Chester) (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Edge Hill University Research Information Repository (Edge Hill University) (submittedVersion)
- Radar (Oxford Brookes University) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- adjuvant endocrine therapy, breast cancer, medication adherence, intentional non-adherence, unintentional non-adherence, treatment side effects, quality of life, sociodemographic factors, patient support interventions
- MeSH terms
- Assessment of Medication Adherence, Adult, Aged, Aged, 80 and over, Androstadienes, Breast Neoplasms, Cross-Sectional Studies, Female, Humans, Middle Aged, Logistic Models, Drug Monitoring, Chemotherapy, Adjuvant, Antineoplastic Agents, Hormonal, Aromatase Inhibitors, Medication Adherence
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