A qualitative study of the attitudes of patients in an early intervention service towards antipsychotic long-acting injections
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Objectives: The objective of this study was to investigate attitudinal themes to antipsychotic long-acting injections (LAIs) in patients in an early intervention team (EIT). Methods: Interviews were carried out with outpatients purposively sampled from an EIT to represent patients currently prescribed antipsychotic LAIs, oral antipsychotics and those not prescribed antipsychotic medication. Interviews were conducted and analysed according to grounded theory. Recruitment stopped when saturation of themes was reached. Results: Interviews from 11 patients were analysed (median age 24 years). Attitudes to LAIs were condensed into three key categories: therapeutic alliance and the psychiatrists’ recommendation of antipsychotic medication; patients’ knowledge and beliefs about LAIs; and patients’ views regarding the appropriateness of LAIs. Participants valued their psychiatrist’s recommendation as to the most appropriate antipsychotic. Attitudes to LAIs varied but were most positive among those currently receiving a LAI. Among those not prescribed LAIs, some were open to considering a LAI if their clinician recommended it but others were opposed to such treatment and preferred tables. There was a lack of awareness of LAIs as a treatment option among those not prescribed a LAI. Delay in being offered a LAI was reported in the group currently prescribed a LAI. Several participants associated oral antipsychotics, LAIs and mental illness with stigma. Some not prescribed a LAI had misperceptions about the nature of this treatment. Participants regarded the advantages of LAIs as convenience and avoiding forgetting to take tablets, while disadvantages included injection pain, fear of needles and coercion. Conclusion: Lack of knowledge, misperceptions and stigma related to LAIs and other treatment options should be addressed by providing patients with accurate information. This will facilitate patients being involved in choices about treatment, and should they decide to accept medication, which drug and formulation is most appropriate for their needs. Clinicians should avoid making assumptions about patients’ attitudes to LAIs; attitudes vary but some early intervention patients not prescribed LAIs are open to considering this treatment. Antipsychotic prescribing should result from a shared decision-making process in which clinicians and patients openly discuss the pros and cons of different formulations and drugs. The themes identified in this qualitative study require further exploration using quantitative methodology.
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In a qualitative study with young patients with psychosis, patients prefer LAIs because they do not have to remember to take pills every day.
“In a qualitative study with young patients with psychosis, Das et al. [63] found that patients prefer LAIs, since they do not have to remember to take pills every day.”
From The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: A clinical review (2020) · cites this paper as [63]
Cites
Basics of Qualitative Research: Grounded Theory Procedures and Techniques.
Ellis, C., Strauss, A., & Corbin, J. M. (1992) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2074814 · Cited by 29,279 · see citing works
Qualitative Analysis for Social Scientists
Strauss, A. L. (1987) · doi:10.1017/cbo9780511557842 · Cited by 12,277 · see citing works
Discovering the Neural Basis of Human Social Anxiety: A Diagnostic and Therapeutic Imperative
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.1 · Cited by 1,428 · see citing works
Tiihonen, J., Haukka, J., Taylor, M., Haddad, P. M., Patel, M. X., & Korhonen, P. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10081224 · Cited by 619 · see citing works
Self-citationNonadherence with antipsychotic medication in schizophrenia: challenges and management strategies
Haddad, P. M., Brain, C., & Scott, J. L. (2014) · Patient Related Outcome Measures · doi:10.2147/prom.s42735 · Cited by 587 · see citing works
Self-citationKishimoto, T., Robenzadeh, A., Leucht, C., Leucht, S., Watanabe, K., Mimura, M., Borenstein, M., Kane, J. M., & Correll, C. U. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs150 · Cited by 395 · see citing works
Efficacy and Effectiveness of Depot Versus Oral Antipsychotics in Schizophrenia
Kirson, N. Y., Weiden, P. J., Yermakov, S., Huang, W., Samuelson, T., Offord, S. J., Greenberg, P. E., & Wong, B. J. O. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r08167 · Cited by 177 · see citing works
Attitudes of Psychiatrists Toward Antipsychotic Depot Medication
Heres, S., Hamann, J., Kissling, W., & Leucht, S. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1216 · Cited by 152 · see citing works
Jaeger, M., & Wulf Rössler, A. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.11.003 · Cited by 144 · see citing works
Predictors of Risk of Nonadherence in Outpatients With Schizophrenia and Other Psychotic Disorders
Weiss, K. A., Smith, T. E., Hull, J. W., Piper, A. C., & Huppert, J. D. (2002) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006943 · Cited by 133 · see citing works
Patel, M., Haddad, P. M., Chaudhry, I. B., McLoughlin, S., & David, A. S. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109104882 · Cited by 115 · see citing works
Self-citationDassa, D., Boyer, L., Benoît, M., Bourcet, S., Raymondet, P., & Bottaï, T. (2010) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048674.2010.493503 · Cited by 111 · see citing works
Psychiatrists' attitudes to maintenance medication for patients with schizophrenia
Patel, M. X., Nikolaou, V., & David, A. S. (2002) · Psychological Medicine · doi:10.1017/s0033291702006797 · Cited by 110 · see citing works
Waddell, L., & Taylor, M. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.195.52.s43 · Cited by 109 · see citing works
Psychoeducation in schizophrenia: new developments and approaches in the field
Rummel‐Kluge, C., & Kissling, W. (2008) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3282f4e574 · Cited by 90 · see citing works
McCabe, R., Healey, P. G. T., Priebe, S., Lavelle, M., Dodwell, D., Laugharne, R. A., Snell, A., & Bremner, S. A. (2013) · Patient Education and Counseling · doi:10.1016/j.pec.2013.05.015 · Cited by 81 · see citing works
Heres, S., Reichhart, T., Hamann, J., Mendel, R., Leucht, S., & Kissling, W. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2009.12.020 · Cited by 64 · see citing works
A qualitative analysis of influences on recovery following a first episode of psychosis
Windell, D., & Norman, R. M. G. (2012) · International Journal of Social Psychiatry · doi:10.1177/0020764012443751 · Cited by 63 · see citing works
Should long-acting (depot) antipsychotics be used in early schizophrenia? A systematic review
Taylor, M., & Ng, K. Y. B. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412470010 · Cited by 62 · see citing works
Kirschner, M., Theodoridou, A., Fusar‐Poli, P., Kaiser, S., & Jäger, M. (2012) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125312464106 · Cited by 62 · see citing works
Long‐acting injectable antipsychotics in early psychosis: a literature review
Emsley, R., Chiliza, B., Asmal, L., Mashile, M., & Fusar‐Poli, P. (2013) · Early Intervention in Psychiatry · doi:10.1111/eip.12027 · Cited by 61 · see citing works
Are depot antipsychotics more coercive than tablets?: The patient’s perspective
Patel, M., de Zoysa, N., Bernadt, M., Bindman, J., & David, A. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109103133 · Cited by 47 · see citing works
Identifying the profile of optimal candidates for antipsychotic depot therapy
Heres, S., Hamann, J., Mendel, R., Wickelmaier, F., Pajonk, F., Leucht, S., & Kissling, W. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.09.025 · Cited by 36 · see citing works
Patient and professional accuracy of recalled treatment decisions in out‐patient consultations
Skinner, T. C., Barnard, K. D., Cradock, S., & Parkin, T. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02129.x · Cited by 35 · see citing works
Ascher‐Svanum, H., Peng, X., Faries, D. E., et al. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-46 · Cited by 29 · see citing works
Antipsychotic long-acting injections
(2010) · Oxford University Press eBooks · doi:10.1093/med/9780199586042.001.0001 · Cited by 19 · see citing works
Novick, D., Haro, J. M., Bertsch, J., et al. (2012) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e328354db12 · Cited by 13 · see citing works
Adverse effects and antipsychotic long-acting injections
Haddad, P. M., & Fleischhacker, W. W. (2016) · Oxford University Press eBooks · doi:10.1093/med/9780198729471.003.0003 · Cited by 8 · see citing works
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Fiorillo, A., Barlati, S., Bellomo, A., Corrivetti, G., Nicolò, G., Sampogna, G., Stanga, V., Veltro, F., Maina, G., & Vita, A. (2020) · Annals of General Psychiatry · doi:10.1186/s12991-020-00293-4 · Cited by 110 · see citing works
- Authors
- Das, A. K., Malik, A., & Haddad, P. M.
- Affiliations
- Homewood Health Centre (CA)
- University of Manchester (GB)
- Venue
- Therapeutic Advances in Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2014-07-11
- Volume
- 4
- Issue
- 5
- Pages
- 179-185
- ISSN
- 2045-1253 (ISSN-L)
- 2045-1261
- PMC
- PMC4212491
- OpenAlex
- W2335555764
- Cited by
- 54
- References
- 28
- Citations by year
- 2026: 7 · 2025: 3 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 2 · 2015: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Therapeutic Advances in Psychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Keywords
- patient attitudes, early intervention in psychosis, therapeutic relationship, shared decision-making, stigma, oral antipsychotics, patient knowledge and beliefs, treatment delay, coercion, injection pain, mental health stigma
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