Cited by 227Schizophrenia research and treatmentEating Disorders and BehaviorsObesity, Physical Activity, Diet

Evaluating an individualized lifestyle and life skills intervention to prevent antipsychotic-induced weight gain in first-episode psychosis

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Curtis, Jackie, Watkins, Andrew, Rosenbaum, Simon, Teasdale, Scott, Kalucy, Megan, Samaras, Katherine, Ward, Philip B.·2016·Early Intervention in Psychiatry

Abstract

AIM: Initiating antipsychotic medication frequently induces rapid, clinically significant weight gain. We aimed to evaluate the effectiveness of a lifestyle and life skills intervention, delivered within 4 weeks of antipsychotic medication initiation, in attenuating weight gain in youth aged 14-25 years with first-episode psychosis (FEP). METHODS: We undertook a prospective, controlled study in two early psychosis community services. Intervention participants (n = 16) received a 12-week individualized intervention delivered by specialist clinical staff (nurse, dietician and exercise physiologist) and youth peer wellness coaches, in addition to standard care. A comparison group was recruited from a similar service and received standard care (n = 12). RESULTS: The intervention group experienced significantly less weight gain at 12 weeks compared to standard care (1.8 kg, 95% CI -0.4 to 2.8 vs. 7.8 kg, 4.8-10.7, P < 0.001). Thirteen per cent (2/16) of the intervention group experienced clinically significant weight gain (greater than 7% of baseline weight), while 75% (9/12) of the standard care group experienced this level of weight gain. Similar positive effects of the intervention were observed for waist circumference. CONCLUSIONS: A lifestyle and life skills intervention delivered as part of standard care attenuated antipsychotic-induced weight gain in young people with FEP. The intervention was acceptable to the young people referred to the service. Such interventions may prevent the seeding of future disease risk and in the long-term help reduce the life expectancy gap for people living with serious mental illness.

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Crossref · 10.1111/eip.12230

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Authors
Curtis, J., Watkins, A., Rosenbaum, S., Teasdale, S., Kalucy, M., Samaras, K., & Ward, P. B.
Affiliations
  • UNSW Sydney (AU)
  • University of Technology Sydney (AU)
  • The University of Sydney (AU)
  • Garvan Institute of Medical Research (AU)
Corresponding author
Ward, Philip B.
Venue
Early Intervention in Psychiatry
Publisher
Wiley
Published
2015-02-26
Volume
10
Issue
3
Pages
267-276
ISSN
  • 1751-7885 (ISSN-L)
  • 1751-7893
OpenAlex
W2102323960
Cited by
227
References
40
Citations by year
2026: 6 · 2025: 9 · 2024: 9 · 2023: 20 · 2022: 20 · 2021: 26 · 2020: 23 · 2019: 21 · 2018: 34 · 2017: 18 · 2016: 33 · 2015: 7 · 2014: 1
FWCI
24.92
Type
journal article
Language
en
Open access
Locations
  • Early Intervention in Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
Funders
Mental Health and Drug & Alcohol Office (MHDAO)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
antipsychotic-induced weight gain, first-episode psychosis, lifestyle intervention, life skills intervention, youth mental health, early psychosis, waist circumference, weight gain prevention, life expectancy gap
MeSH terms
Adaptation, Psychological, Adolescent, Adult, Counseling, Female, Humans, Life Style, Male, Psychotic Disorders, Antipsychotic Agents, Weight Gain, Young Adult

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