Predictors of survival and progression in behavioural variant frontotemporal dementia
Abstract
Background and purpose: Predicting the course of behavioural variant frontotemporal dementia (bv FTD ) remains a major clinical challenge. This study aimed to identify factors that predict survival and clinical progression in bv FTD . Methods: Consecutive patients with clinically probable bv FTD were prospectively followed up over an 8‐year period. Baseline neuropsychological variables, presence of a known pathogenic frontotemporal dementia gene mutation and a systematic visual magnetic resonance imaging assessment at baseline were examined as candidate predictors using multivariate modelling. Results: After screening 121 cases, the study cohort consisted of 75 patients with probable bv FTD , with a mean age of 60.8 ± 8.5 years, followed up for a mean duration of 7.2 ± 3.5 years from symptom onset. Median survival time from disease onset was 10.8 years and median survival, prior to transition to nursing home, was 8.9 years. A total of 25 of the 75 patients died during the study follow‐up period. Survival without dependence was predicted by shorter disease duration at presentation (hazard ratio, 0.49, P = 0.001), greater atrophy in the anterior cingulate cortex (hazard ratio, 1.75, P = 0.047), older age (hazard ratio, 1.07, P = 0.026) and a higher burden of behavioural symptoms (hazard ratio, 1.04, P = 0.015). In terms of disease progression, presence of a known pathogenic frontotemporal dementia mutation ( β = 0.46, P < 0.001) was the strongest predictor of progression. Deficits in letter fluency ( β = −0.43, P = 0.017) and greater atrophy in the motor cortex ( β = 0.51, P = 0.03) were also associated with faster progression. Conclusions: This study provides novel clinical predictors of survival and progression in bv FTD . Our findings are likely to have an impact on prognostication and care planning in this difficult disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Letter fluency detected decline over 18 months in genetic bvFTD (mostly C9ORF72), associated with frontotemporal atrophy and FTLD-CDR progression.
“Regarding single tests, the letter fluency detected decline over 18 months in genetic bvFTD (mostly C9ORF72), associated to frontotemporal atrophy and FTLD-CDR progression (Floeter et al., 2016, 2017; Agarwal et al., 2019).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Agarwal et al., 2019
Cites
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Self-citationA Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.010 · Cited by 4,409 · see citing works
The prevalence of frontotemporal dementia
Ratnavalli, E., Brayne, C., Dawson, K., & Hodges, J. R. (2002) · Neurology · doi:10.1212/wnl.58.11.1615 · Cited by 1,151 · see citing works
Self-citationSingle subject prediction of brain disorders in neuroimaging: Promises and pitfalls
Arbabshirani, M. R., Plis, S., Sui, J., & Calhoun, V. D. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.079 · Cited by 912 · see citing works
Prediction of institutionalization in the elderly. A systematic review
Luppa, M., Luck, T., Weyerer, S. B., König, H. ‐., Brähler, E., & Riedel-Heller, S. G. (2009) · Age and Ageing · doi:10.1093/ageing/afp202 · Cited by 903 · see citing works
Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS
文治, 木., Fujimura, C., Ishida, S., Nakajima, H., Furutama, D., Uehara, H., Shinoda, K., Sugino, M., & Hanafusa, T. (2006) · Neurology · doi:10.1212/01.wnl.0000194316.91908.8a · Cited by 568 · see citing works
Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes
Coyle-Gilchrist, I. T. S., Dick, K. M., Patterson, K. E., Rodríguez, P. V., Wehmann, E., Wilcox, A., Lansdall, C. J., Dawson, K., Wiggins, J., Mead, S., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002638 · Cited by 546 · see citing works
Strong, M. J., Grace, G. M., Freedman, M., Lomen-Hoerth, C., Woolley, S. C., Goldstein, L. H., Murphy, J. M., Shoesmith, C. L., Rosenfeld, J., Leigh, P. N., et al. (2009) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960802654364 · Cited by 543 · see citing works
Rohrer, J. D., Nicholas, J. M., Cash, D. M., van Swieten, J., Dopper, E., Jiskoot, L., van Minkelen, R., Rombouts, S. A., Cardoso, M. J., Clegg, S., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70324-2 · Cited by 538 · see citing works
Survival in frontotemporal dementia
Hodges, J. R., Davies, R., Xuereb, J. H., Kril, J. J., & Halliday, G. M. (2003) · Neurology · doi:10.1212/01.wnl.0000078928.20107.52 · Cited by 406 · see citing works
Self-citationThe frontotemporal dementia-motor neuron disease continuum
Burrell, J. R., Halliday, G. M., Kril, J. J., Ittner, L. M., Götz, J., Kiernan, M. C., & Hodges, J. R. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00737-6 · Cited by 369 · see citing works
Self-citationMotor Neuron dysfunction in frontotemporal dementia
Burrell, J. R., Kiernan, M. C., Vucic, S., & Hodges, J. R. (2011) · Brain · doi:10.1093/brain/awr195 · Cited by 339 · see citing works
Self-citationSequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD)
Brettschneider, J., Tredici, K. D., Irwin, D. J., Grossman, M., Robinson, J. L., Toledo, J. B., Fang, L., Deerlin, V. M. V., Ludolph, A. C., Lee, V. M. ‐., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1238-y · Cited by 314 · see citing works
Rate of disease progression: A prognostic biomarker in ALS
Labra, J., Menon, P., Byth, K., Morrison, S., & Vucic, S. (2016) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-310998 · Cited by 209 · see citing works
Progression in Frontotemporal Dementia
Davies, R., Kipps, C., Mitchell, J., Kril, J. J., Halliday, G. M., & Hodges, J. R. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1627 · Cited by 191 · see citing works
Self-citationComputational neuroimaging strategies for single patient predictions
Stephan, K. E., Schlagenhauf, F., Huys, Q. J. M., Raman, S., Aponte, E. A., Brodersen, K. H., Rigoux, L., Moran, R., Jean Daunizeau, A., Dolan, R. J., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.06.038 · Cited by 166 · see citing works
Irwin, D. J., McMillan, C. T., Brettschneider, J., Libon, D. J., Powers, J., Rascovsky, K., Toledo, J. B., Boller, A., Bekisz, J. M., Chandrasekaran, K., et al. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303507 · Cited by 153 · see citing works
Executive function in progressive and nonprogressive behavioral variant frontotemporal dementia
Hornberger, M., Piguet, O., Kipps, C., & Hodges, J. R. (2008) · Neurology · doi:10.1212/01.wnl.0000334299.72023.c8 · Cited by 151 · see citing works
Self-citationWhitwell, J. L., Boeve, B. F., Weigand, S. D., Senjem, M. L., Gunter, J. L., Baker, M., DeJesus‐Hernandez, M., Knopman, D. S., Wszolek, Z. K., Petersen, R. C., et al. (2015) · European Journal of Neurology · doi:10.1111/ene.12675 · Cited by 119 · see citing works
Landin-Romero, R., Kumfor, F., Leyton, C. E., Irish, M., Hodges, J. R., & Piguet, O. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.032 · Cited by 116 · see citing works
Self-citationGendron, T. F., Daughrity, L. M., Heckman, M. G., Diehl, N. N., Wuu, J., Miller, T. M., Pástor, P., Trojanowski, J. Q., Grossman, M., Berry, J. D., et al. (2017) · Annals of Neurology · doi:10.1002/ana.24980 · Cited by 112 · see citing works
Davies, R., Scahill, V. L., Graham, A., Williams, G. B., Graham, K. S., & Hodges, J. R. (2009) · Neuroradiology · doi:10.1007/s00234-009-0521-z · Cited by 109 · see citing works
Self-citationSurvival in Frontotemporal Dementia Phenotypes: A Meta-Analysis
Kansal, K., Mareddy, M., Sloane, K. L., Minc, A. A., Rabins, P. V., McGready, J., & Onyike, C. U. (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000443205 · Cited by 101 · see citing works
Determinants of survival in behavioral variant frontotemporal dementia
Garcin, B., Lillo, P., Hornberger, M., Piguet, O., Dawson, K., Nestor, P. J., & Hodges, J. R. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c1dee7 · Cited by 94 · see citing works
Self-citationComparative analysis of C9orf72 and sporadic disease in an ALS clinic population
Umoh, M. E., Fournier, C. N., Li, Y., Polak, M. A., Shaw, L., Landers, J. E., Hu, W. T., Gearing, M., & Glass, J. D. (2016) · Neurology · doi:10.1212/wnl.0000000000003067 · Cited by 88 · see citing works
Apathy: A neurocircuitry model based on frontotemporal dementia
Ducharme, S., Price, B. H., & Dickerson, B. C. (2018) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316277 · Cited by 69 · see citing works
Borroni, B., Agosti, C., Premi, E., Cerini, C., Cosseddu, M., Paghera, B., Bellelli, G., & Padovani, A. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02911.x · Cited by 65 · see citing works
Progression in Behavioral Variant Frontotemporal Dementia: A Longitudinal Study
Devenney, E., Bartley, L., Hoon, C., O’Callaghan, C., Kumfor, F., Hornberger, M., Kwok, J. B., Halliday, G. M., Kiernan, M. C., Piguet, O., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.2061 · Cited by 61 · see citing works
Self-citationAutomatic measurement of prosody in behavioral variant FTD
Nevler, N., Ash, S., Jester, C., Irwin, D. J., Liberman, M., & Grossman, M. (2017) · Neurology · doi:10.1212/wnl.0000000000004236 · Cited by 61 · see citing works
Predicting survival in frontotemporal dementia with motor neuron disease
Coon, E. A., Sorenson, E. J., Whitwell, J. L., Knopman, D. S., & Josephs, K. A. (2011) · Neurology · doi:10.1212/wnl.0b013e31821d767b · Cited by 45 · see citing works
The bvFTD phenocopy syndrome: a clinicopathological report
Devenney, E. M., Forrest, S. L., Xuereb, J. H., Kril, J. J., & Hodges, J. R. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-312826 · Cited by 26 · see citing works
Self-citationClinical heterogeneity of the C9orf72 genetic mutation in frontotemporal dementia
Devenney, E. M., Foxe, D., Dobson‐Stone, C., Kwok, J. B., Kiernan, M. C., & Hodges, J. R. (2014) · Neurocase · doi:10.1080/13554794.2014.951058 · Cited by 23 · see citing works
Self-citationGenetic Background Predicts Poor Prognosis in Frontotemporal Lobar Degeneration
Borroni, B., Grassi, M., Archetti, S., Papetti, A., Bo, R. D., Bonvicini, C., Comi, G. P., Gennarelli, M., Bellelli, G., Luca, M. D., et al. (2011) · Neurodegenerative Diseases · doi:10.1159/000322790 · Cited by 18 · see citing works
Mendelian forms of disease and age at onset affect survival in frontotemporal dementia
Cosseddu, M., Benussi, A., Gazzina, S., Turrone, R., Archetti, S., Bonomi, E., Biasiotto, G., Zanella, I., Ferrari, R., Cotelli, M. S., et al. (2017) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2017.1384020 · Cited by 17 · see citing works
Lee, J. S., Jung, N., Jang, Y. K., Kim, Y. J., Seo, S. W., Lee, J., Kim, Y. J., Lee, J., Kim, B. C., Park, K.-W., et al. (2017) · Journal of Clinical Neurology · doi:10.3988/jcn.2017.13.3.234 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition
Murley, A. G., Rouse, M. A., Jones, P. S., Ye, R., Hezemans, F. H., O’Callaghan, C., Frangou, P., Kourtzi, Z., Rua, C., Carpenter, T. A., et al. (2020) · Brain · doi:10.1093/brain/awaa305 · Cited by 101 · see citing works
Benussi, A., Premi, E., Gazzina, S., Brattini, C., Bonomi, E., Alberici, A., Jiskoot, L. C., Swieten, J. C. V., Sánchez‐Valle, R., Moreno, F., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.30194 · Cited by 85 · see citing works
Peet, B. T., Spina, S., Mundada, N., & La Joie, R. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01101-x · Cited by 74 · see citing works
Illán‐Gala, I., Casaletto, K. B., Borrego‐Écija, S., Arenaza‐Urquijo, E. M., Wolf, A. A., Cobigo, Y., Goh, S. M., Staffaroni, A. M., Alcolea, D. A., Fortea, J., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12299 · Cited by 64 · see citing works
Cosseddu, M., Benussi, A., Gazzina, S., Alberici, A., Dell’Era, V., Manes, M. A., Cristillo, V., Borroni, B., & Padovani, A. (2019) · European Journal of Neurology · doi:10.1111/ene.14071 · Cited by 47 · see citing works
Frontotemporal dementias: main syndromes and underlying brain changes
Piguet, O., & Kumfor, F. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000792 · Cited by 46 · see citing works
Self-citationPredicting loss of independence and mortality in frontotemporal lobar degeneration syndromes
Murley, A. G., Rouse, M. A., Coyle-Gilchrist, I. T. S., Jones, P. S., Li, W., Wiggins, J., Lansdall, C. J., Rodríguez, P. V., Wilcox, A., Patterson, K. E., et al. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-324903 · Cited by 44 · see citing works
Predictors of Mortality in Individuals with Dementia in the National Alzheimer’s Coordinating Center
Armstrong, M. J., Song, S., Kurasz, A. M., & Li, Z. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215587 · Cited by 31 · see citing works
Cingulate-centered large-scale networks: Normal functions, aging, and neurodegenerative disease
Touroutoglou, A., & Dickerson, B. C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00008-x · Cited by 23 · see citing works
Genetic predictors of survival in behavioral variant frontotemporal degeneration
Caswell, C., McMillan, C. T., Xie, S. X., Deerlin, V. M. V., Suh, E. R., Lee, E. B., Trojanowski, J. Q., Lee, V. M. ‐., Irwin, D. J., Grossman, M., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000008387 · Cited by 22 · see citing works
Predictors of survival in frontotemporal lobar degeneration syndromes
El‐Wahsh, S., Finger, E. C., Piguet, O., Mok, V., Rohrer, J. D., Kiernan, M. C., & Ahmed, R. M. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-324349 · Cited by 21 · see citing works
Self-citationAhmed, R. M., Hodges, J. R., & Piguet, O. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_1 · Cited by 20 · see citing works
Self-citationClinical Phenotypes of Behavioral Variant Frontotemporal Dementia by Age at Onset
Fieldhouse, J. L. P., Gossink, F. T., Feenstra, T. C., de Boer, S. C. M., Lemstra, A. W., Prins, N. D., Bouwman, F. H., Koene, T., Rhodius‐Meester, H. F. M., Gillissen, F., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210179 · Cited by 19 · see citing works
Crossing Borders Between Frontotemporal Dementia and Psychiatric Disorders: An Updated Overview
Vismara, M. E. M., Cirnigliaro, G., Piccoli, E., Giorgetti, F., Molteni, L., Cremaschi, L., Fumagalli, G., D’Addario, C., & Dell’Osso, B. M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191333 · Cited by 14 · see citing works
Deng, B., Zheng, Z., Zheng, J., Yang, W., Huang, Y., Luo, Y., Jin, D., Shen, L. H., Jin, K., & Wang, Q. (2021) · Aging and Disease · doi:10.14336/ad.2021.0309 · Cited by 13 · see citing works
Risk factors to mortality and causes of death in frontotemporal dementia: An Australian perspective
Loi, S. M., Tsoukra, P., Chen, Z. Z., Wibawa, P., Eratne, D., Kelso, W. M., Walterfang, M., & Velakoulis, D. (2021) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5668 · Cited by 12 · see citing works
Borroni, B., Tarantino, B., Graff, C., Krüger, J., Ludolph, A. C., Moreno, F., Otto, M., Rowe, J. B., Seelaar, H., Solje, E., et al. (2024) · Neurology · doi:10.1212/wnl.0000000000209793 · Cited by 11 · see citing works
Piguet, O., Clarke, A. J., Foxe, D., Tse, N. Y., Teng, H., Burrell, J., Cheung, S. C., Carrick, J., Devenney, E., Halliday, G., et al. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70604 · Cited by 10 · see citing works
Self-citationDissecting the Many Faces of Frontotemporal Dementia: An Imaging Perspective
Pengo, M., Premi, E., & Borroni, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112867 · Cited by 9 · see citing works
Fieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
Survival rates in frontotemporal dementia and Alzheimer’s disease
Foxe, D., Muggleton, J., Cheung, S. C., Mueller, N., Ahmed, R. M., Narasimhan, M., Burrell, J. R., Hwang, Y. T., Cordato, N. J., & Piguet, O. (2025) · Neurodegenerative Disease Management · doi:10.1080/17582024.2025.2527553 · Cited by 7 · see citing works
Self-citationKaufman, D. M., Geyer, H. L., Milstein, M. J., & Rosengard, J. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-79680-4.00007-3 · Cited by 6 · see citing works
Cotelli, M. S., Tarantino, B., Tan, K., Huber, H., Cantoni, V., Bracca, V., Gasparotti, R., Premi, E., Logroscino, G., Benedet, A. L., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14558 · Cited by 6 · see citing works
Long, Z., Irish, M., Hodges, J. R., Piguet, O., & Burrell, J. R. (2022) · European Journal of Neurology · doi:10.1111/ene.15518 · Cited by 5 · see citing works
Self-citationJung, N., Park, K. H., Seo, S. W., Kim, H. J., Roh, J. H., Lee, J., Park, K. W., Kwon, J. C., Jeong, J. H., Yoon, S. J., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11082260 · Cited by 2 · see citing works
Neuropsychiatric and behavioral symptom clusters in frontotemporal dementia
Sejourne, C., Barker, M. S., Heath, M. R., Gazes, Y., Fremont, R., Perez, Y. G., Hearne, L. J., Wassermann, E. M., Tierney, M. C., Manoochehri, M., et al. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251324391 · Cited by 1 · see citing works
Bouzigues, A., Grassi, M., Cantoni, V., Premi, E., Bellini, S., Binetti, G. G., Logroscino, G., Russell, L. L., Ferry‐Bolder, E., Foster, P. H., et al. (2026) · The Lancet Neurology · doi:10.1016/s1474-4422(26)00197-3 · Cited by 1 · see citing works
Younger-Onset Dementias: Behavioral Neurology/Brain Diseases/Healthy & Pathological Aging
Piguet, O. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00004-9
Self-citationThe Behavioral Variant of Frontotemporal Dementia: Preclinical to Advanced Dementia
Illán‐Gala, I., & Miller, B. L. (2025) · Cambridge University Press eBooks · doi:10.1017/9781108985055.011
Gündoğdu, A. A., Samancı, B., Alaylıoğlu, M., Şahin, E., Ulukan, Ç., Gurvit, H. I., Dursun, E., Hanagasi, H. A., Gezen‐Ak, D., & Bılgıç, B. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261476236
Marc, M., Lucas, W., Merck, C., Salmon, A., Eustache, F., Laisney, M., & Belliard, S. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71859
- Authors
- Agarwal, S., Ahmed, R. M., D'Mello, M., Foxe, D., Kaizik, C., Kiernan, M. C., Halliday, G. M., Piguet, O., & Hodges, J. R.
- Affiliations
- The University of Sydney (AU)
- School of Psychology and Brain and Mind Centre The University of Sydney Sydney New South Wales
- Corresponding author
- Agarwal, S.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2019-01-29
- Volume
- 26
- Issue
- 5
- Pages
- 774-779
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W2904582713
- Cited by
- 31
- References
- 36
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 3
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (NHMRC‐APP1037746)
- Australian Research Council
- Royal Society of Medicine
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- behavioral variant frontotemporal dementia, survival prediction, disease progression, prognostic factors, phonemic fluency, behavioural symptoms, disease duration, nursing home admission
- MeSH terms
- Age Factors, Aged, Atrophy, Female, Follow-Up Studies, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex, Mutation, Neuropsychological Tests, Nursing Homes, Predictive Value of Tests, Prospective Studies, Cohort Studies, Survival Analysis, Disease Progression, Kaplan-Meier Estimate, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
