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Minimum requirements for the diagnosis of psychogenic nonepileptic seizures: A staged approach: A report from the International League Against Epilepsy Nonepileptic Seizures Task Force
Open accessAbstract
An international consensus group of clinician-researchers in epilepsy, neurology, neuropsychology, and neuropsychiatry collaborated with the aim of developing clear guidance on standards for the diagnosis of psychogenic nonepileptic seizures (PNES). Because the gold standard of video electroencephalography (vEEG) is not available worldwide, or for every patient, the group delineated a staged approach to PNES diagnosis. Using a consensus review of the literature, this group evaluated key diagnostic approaches. These included: history, EEG, ambulatory EEG, vEEG/monitoring, neurophysiologic, neurohumoral, neuroimaging, neuropsychological testing, hypnosis, and conversation analysis. Levels of diagnostic certainty were developed including possible, probable, clinically established, and documented diagnosis, based on the availability of history, witnessed event, and investigations, including vEEG. The aim and hope of this report is to provide greater clarity about the process and certainty of the diagnosis of PNES, with the intent to improve the care for people with epilepsy and nonepileptic seizures.
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Ricci, L., Boscarino, M., Assenza, G., Tombini, M., Lanzone, J., Lazzaro, V. D., Casciato, S., D’Aniello, A., Morano, A., Gennaro, G. D., et al. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05040-5 · Cited by 51
Machine learning as a diagnostic decision aid for patients with transient loss of consciousness
Wardrope, A., Jamnadas-Khoda, J., Broadhurst, M., Grünewald, R. A., Heaton, T., Howell, S. J., Koepp, M. J., Parry, S. W., Sisodiya, S. M., Walker, M. C., et al. (2020) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000000726 · Cited by 52
Providers' perspectives on treating psychogenic nonepileptic seizures: Frustration and hope
McMillan, K. K., Pugh, M. J., Altalib, H. H., Salinsky, M., Pugh, J. A., Noël, P. H., Finley, E. P., Leykum, L. K., Lanham, H. J., & LaFrance, W. C., Jr. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.07.001 · Cited by 50
de Paola, L., Terra, V. C., Silvado, C. E., Teive, H. A. G., Palmini, A., Valente, K. D. R., Olandoski, M., & LaFrance, W. C., Jr. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.10.025 · Cited by 50
Neurologic diagnostic criteria for functional neurologic disorders.
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Video ambulatory EEG: A good alternative to inpatient video telemetry?
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Beniczky, S., Conradsen, I., Moldovan, M., Jennum, P., Fabricius, M. E., Benedek, K., Andersen, N., Hjalgrim, H., & Wolf, P. (2014) · Epilepsia · doi:10.1111/epi.12669 · Cited by 49
Functional neurological disorders: acute presentations and management
Cock, H. R., & Edwards, M. J. (2018) · Clinical Medicine · doi:10.7861/clinmedicine.18-5-414 · Cited by 49
Are psychogenic non-epileptic seizures just another symptom of conversion disorder?
Kanaan, R., Duncan, R., Goldstein, L. H., Jankovic, J. J., & Cavanna, A. E. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-315639 · Cited by 48
Pediatric Psychogenic Nonepileptic Seizures
Doss, J. L., & Plioplys, S. (2017) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2017.08.007 · Cited by 48
Medical management of epileptic seizures: challenges and solutions
Brophy, G. M., Sarma, A. K., Khandker, N., & Kurczewski, L. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s80586 · Cited by 47
Goldstein, L. H., Robinson, E. J., Mellers, J. D. C., Stone, J., Carson, A. J., Chalder, T., Reuber, M., Eastwood, C., Landau, S., McCrone, P., et al. (2020) · Psychological Medicine · doi:10.1017/s0033291720001051 · Cited by 47
Faiman, I., Smith, S. D. W., Hodsoll, J. P., Young, A. H., & Shotbolt, P. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2021.108047 · Cited by 48
Adherence with psychotherapy and treatment outcomes for psychogenic nonepileptic seizures
Tolchin, B. D., Dworetzky, B. A., Martino, S., Blumenfeld, H., Hirsch, L. J., & Baslet, G. C. (2019) · Neurology · doi:10.1212/wnl.0000000000006848 · Cited by 46
Automated differentiation between epileptic and nonepileptic convulsive seizures
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Epileptic vs psychogenic nonepileptic seizures: a video-based survey
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Gasparini, S., Campolo, M., Ieracitano, C., Mammone, N., Ferlazzo, E., Sueri, C., Tripodi, G. G., Aguglia, U., & Morabito, F. C. (2018) · Entropy · doi:10.3390/e20020043 · Cited by 44
Metadata
- Authors
- LaFrance, W. C., Baker, G. A., Duncan, R., Goldstein, L. H., & Reuber, M.
- Affiliations
- Division of Neuropsychiatry and Behavioral Neurology Rhode Island Hospital Providence Rhode Island U.S.A
- University of Liverpool (GB)
- Christchurch Hospital (NZ)
- King's College London (GB)
- Royal Hallamshire Hospital (GB)
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2013-09-20
- Volume
- 54
- Issue
- 11
- Pages
- 2005-2018
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1946832819
- Cited by
- 856
- References
- 160
- Citations by year
- 2026: 62 · 2025: 79 · 2024: 83 · 2023: 68 · 2022: 71 · 2021: 87 · 2020: 97 · 2019: 60 · 2018: 95 · 2017: 55 · 2016: 41 · 2015: 30 · 2014: 25 · 2013: 1
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- psychogenic non-epileptic seizures, diagnosis, video electroencephalography, diagnostic certainty, hypnosis, conversation analysis, neuroimaging, neuropsychological assessment, medical history, non-epileptic seizures
- MeSH terms
- Diagnosis, Differential, Electroencephalography, Humans, Monitoring, Physiologic, Neuropsychological Tests, Seizures, Advisory Committees
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