Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders
Open accessAbstract
OBJECTIVE: Adverse early-life events are predisposing factors for functional neurological disorder (FND) and post-traumatic stress disorder (PTSD). Cingulo-insular regions are implicated in the biology of both conditions and are sites of stress-mediated neuroplasticity. We hypothesised that functional neurological symptoms and the magnitude of childhood abuse would be associated with overlapping anterior cingulate cortex (ACC) and insular volumetric reductions, and that FND and PTSD symptoms would map onto distinct cingulo-insular areas. METHODS: This within-group voxel-based morphometry study probes volumetric associations with self-report measures of functional neurological symptoms, adverse life events and PTSD symptoms in 23 mixed-gender FND patients. Separate secondary analyses were also performed in the subset of 18 women with FND to account for gender-specific effects. RESULTS: Across the entire cohort, there were no statistically significant volumetric associations with self-report measures of functional neurological symptom severity or childhood abuse. In women with FND, however, parallel inverse associations were observed between left anterior insular volume and functional neurological symptoms as measured by the Patient Health Questionnaire-15 and the Screening for Somatoform Symptoms Conversion Disorder subscale. Similar inverse relationships were also appreciated between childhood abuse burden and left anterior insular volume. Across all subjects, PTSD symptom severity was inversely associated with dorsal ACC volume, and the magnitude of lifetime adverse events was inversely associated with left hippocampal volume. CONCLUSIONS: This study reveals distinct cingulo-insular alterations for FND and PTSD symptoms and may advance our understanding of FND. Potential biological convergence between stress-related neuroplasticity, functional neurological symptoms and reduced insular volume was identified.
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Cohort studies have identified positive associations between the magnitude of previously experienced adverse life experiences and functional neurological symptom severity.
“Importantly, cohort studies have identified positive associations between the magnitude of previously experienced adverse life experiences and functional neurological symptom severity, underscoring the aetiological importance of adverse life experiences in this population 169,192,[197][198][199]”
From A new science of emotion: implications for functional neurological disorder (2022) · cites this paper as [199]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
(1970) · Cited by 24,983 · see citing works
Diagnostic and Statistical Manual of Mental Disorders(DSM)
Leong, F. T. L. (2008) · Sage eBooks · doi:10.4135/9781412963978.n182 · Cited by 10,858 · see citing works
Beck, A. T., Steer, R. A., & Brown, G. (2011) · PsycTESTS Dataset · doi:10.1037/t00742-000 · Cited by 7,535 · see citing works
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · see citing works
Blevins, C. A., Weathers, F. W., Davis, M. T., Witte, T. K., & Domino, J. L. (2015) · Journal of Traumatic Stress · doi:10.1002/jts.22059 · Cited by 5,233 · see citing works
Initial reliability and validity of a new retrospective measure of child abuse and neglect
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.8.1132 · Cited by 3,577 · see citing works
The PHQ-15: Validity of a New Measure for Evaluating the Severity of Somatic Symptoms
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200203000-00008 · Cited by 3,305 · see citing works
The integration of negative affect, pain and cognitive control in the cingulate cortex
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., & Davidson, R. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2994 · Cited by 2,082 · see citing works
Biological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529 · see citing works
Paulus, M. P., & Stein, M. B. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.042 · Cited by 1,325 · see citing works
Teicher, M. H., & Samson, J. A. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12070957 · Cited by 1,050 · see citing works
Childhood abuse and lifetime psychopathology in a community sample
MacMillan, H. L., Fleming, J. E., Streiner, D. L., Lin, E., Boyle, M. H., Jamieson, E., Duku, E. K., Walsh, C. A., Wong, M. Y.-Y., & Beardslee, W. R. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1878 · Cited by 1,035 · see citing works
Dannlowski, U., Stuhrmann, A., Beutelmann, V., Zwanzger, P., Lenzen, T., Grotegerd, D., Domschke, K., Hohoff, C., Ohrmann, P., Bauer, J., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.021 · Cited by 954 · see citing works
BARSKY, A. J., Orav, E. J., & Bates, D. W. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.8.903 · Cited by 912 · see citing works
Self-citationLaFrance, W. C., Baker, G. A., Duncan, R., Goldstein, L. H., & Reuber, M. (2013) · Epilepsia · doi:10.1111/epi.12356 · Cited by 856 · see citing works
Who is referred to neurology clinics?—The diagnoses made in 3781 new patients
Stone, J., Carson, A. J., Duncan, R., Roberts, R., Warlow, C., Hibberd, C., Coleman, R. J., Cull, R. E., Murray, G. D., Pelosi, A. J., et al. (2010) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2010.05.011 · Cited by 538 · see citing works
Psychodynamics and psychiatric diagnoses of pseudoseizure subjects
Bowman, E. S., & Markand, O. N. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.1.57 · Cited by 495 · see citing works
Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei
Cohen, R. A., Grieve, S., Hoth, K. F., Paul, R. H., Sweet, L., Tate, D., Gunstad, J., Stroud, L., McCaffery, J., Hitsman, B., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.016 · Cited by 439 · see citing works
Yamasue, H., Kasai, K., Iwanami, A., Ohtani, T., Yamada, H., Abe, O., Kuroki, N., Fukuda, R., Tochigi, M., Furukawa, S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530467100 · Cited by 381 · see citing works
The prognosis of functional (psychogenic) motor symptoms: a systematic review
Gelauff, J., Stone, J., Edwards, M., & Carson, A. (2014) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-305321 · Cited by 368 · see citing works
Ansell, E. B., Rando, K., Tuit, K., Guarnaccia, J., & Sinha, R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.022 · Cited by 354 · see citing works
Childhood trauma, dissociation, and psychiatric comorbidity in patients with conversion disorder
Şar, V., Akyüz, G., Kundakçı, T., Kızıltan, E., & Doğan, O. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.12.2271 · Cited by 347 · see citing works
Gray matter abnormalities in childhood maltreatment: a voxel-wise meta-analysis
Lim, L., Radua, J., & Rubia, K. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13101427 · Cited by 336 · see citing works
The involuntary nature of conversion disorder
Voon, V., Gallea, C., Hattori, N., Bruno, M., Ekanayake, V., & Hallett, M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ca00e9 · Cited by 335 · see citing works
Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain
Sepulcre, J., Sabuncu, M. R., Yeo, T. B., Liu, H., & Johnson, K. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0759-12.2012 · Cited by 323 · see citing works
Self-citationChildhood abuse in patients with conversion disorder
Roelofs, K., Keijsers, G. P. J., Hoogduin, K. A. L., Näring, G. W. B., & Moene, F. C. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1908 · Cited by 276 · see citing works
Gray Matter Correlates of Posttraumatic Stress Disorder: A Quantitative Meta-Analysis
Kühn, S., & Gallinat, J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.029 · Cited by 259 · see citing works
Phenomenology and psychopathology related to psychogenic movement disorders.
Williams, D. T., Ford, B., & Fahn, S. (1995) · PubMed · Cited by 243 · see citing works
Voon, V., Brezing, C., Gallea, C., & Hallett, M. (2011) · Movement Disorders · doi:10.1002/mds.23890 · Cited by 237 · see citing works
Impaired self-agency in functional movement disorders
Maurer, C. W., LaFaver, K., Ameli, R., Epstein, S. A., Hallett, M., & Horovitz, S. G. (2016) · Neurology · doi:10.1212/wnl.0000000000002940 · Cited by 228 · see citing works
Emotion-motion interactions in conversion disorder: An FMRI study
Aybek, S., Nicholson, T. R., O’Daly, O., Zelaya, F., Kanaan, R. A., & David, A. S. (2015) · PLOS ONE · doi:10.1371/journal.pone.0123273 · Cited by 183 · see citing works
Nonepileptic seizures: an updated review
Perez, D. L., & LaFrance, W. C., Jr. (2016) · CNS Spectrums · doi:10.1017/s109285291600002x · Cited by 179 · see citing works
Self-citationNeuroanatomic correlates of psychogenic nonepileptic seizures: A cortical thickness and VBM study
Labate, A., Cerasa, A., Mula, M., Mumoli, L., Gioia, M. C., Aguglia, U., Quattrone, A., & Gambardella, A. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2011.03347.x · Cited by 171 · see citing works
A New Approach to the Assessment of the Treatment Effects of Somatoform Disorders
Rief, W., & Hiller, W. (2003) · Psychosomatics · doi:10.1176/appi.psy.44.6.492 · Cited by 171 · see citing works
fMRI in Patients With Motor Conversion Symptoms and Controls With Simulated Weakness
Stone, J., Zeman, A. Z., Simonotto, E., Meyer, M. E., Azuma, R., Flett, S., & Sharpe, M. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31815b6c14 · Cited by 170 · see citing works
Valet, M., Gündel, H., Sprenger, T., Sorg, C., Mühlau, M., Zimmer, C., Henningsen, P., & Tölle, T. R. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31818d1e02 · Cited by 167 · see citing works
Voon, V., Cavanna, A. E., Coburn, K. L., Sampson, S. M., Reeve, A., & LaFrance, W. C., Jr. (2016) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.14090217 · Cited by 162 · see citing works
A Neural Circuit Framework for Somatosensory Amplification in Somatoform Disorders
Perez, D. L., BARSKY, A. J., Vago, D. R., Baslet, G. C., & Silbersweig, D. (2014) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13070170 · Cited by 148 · see citing works
Self-citationChen, S., Xia, W., Li, L., Liu, J., He, Z., Zhang, Z., Yan, L., Zhang, J., & Hu, D. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.09.006 · Cited by 137 · see citing works
Bevilacqua, L. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.152 · Cited by 137 · see citing works
Predictors of antecedent factors in psychogenic nonepileptic attacks
Duncan, R., & Oto, M. (2008) · Neurology · doi:10.1212/01.wnl.0000326593.50863.21 · Cited by 124 · see citing works
Perez, D. L., Dworetzky, B. A., Dickerson, B. C., Leung, L., Cohn, R., Baslet, G. C., & Silbersweig, D. (2014) · Clinical EEG and Neuroscience · doi:10.1177/1550059414555905 · Cited by 123 · see citing works
Self-citationSelkirk, M., Duncan, R., Oto, M., & Pelosi, A. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01611.x · Cited by 119 · see citing works
Motor Conversion Symptoms and Pseudoseizures: A Comparison of Clinical Characteristics
Stone, J., Sharpe, M., & Binzer, M. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.6.492 · Cited by 105 · see citing works
Driver‐Dunckley, E. D., Stonnington, C. M., Locke, D. E. C., & Noe, K. H. (2011) · Psychosomatics · doi:10.1016/j.psym.2011.01.008 · Cited by 68 · see citing works
Cortical thickness, surface area and folding in patients with psychogenic nonepileptic seizures
Ristić, A. J., Daković, M. Z., Kerr, M., Kovačević, M., Parojčić, A., & Sokić, D. V. (2015) · Epilepsy Research · doi:10.1016/j.eplepsyres.2015.02.015 · Cited by 63 · see citing works
Motor and Somatosensory Conversion Disorder: A Functional Unawareness Syndrome?
Perez, D. L., BARSKY, A. J., Daffner, K. R., & Silbersweig, D. (2012) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.11050110 · Cited by 56 · see citing works
Self-citationA structural MRI study of motor conversion disorder: evidence of reduction in thalamic volume
Nicholson, T. R., Aybek, S., Kempton, M. J., Daly, E., Murphy, D., David, A. S., & Kanaan, R. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-305012 · Cited by 55 · see citing works
Providers' perspectives on treating psychogenic nonepileptic seizures: Frustration and hope
McMillan, K. K., Pugh, M. J., Altalib, H. H., Salinsky, M., Pugh, J. A., Noël, P. H., Finley, E. P., Leykum, L. K., Lanham, H. J., & LaFrance, W. C., Jr. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.07.001 · Cited by 50 · see citing works
Carson, A. J., Stone, J., Hansen, C. H., Duncan, R., Cavanagh, J., Matthews, K., Murray, G. D., & Sharpe, M. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308234 · Cited by 45 · see citing works
Hospital revisit rate after a diagnosis of conversion disorder
Merkler, A. E., Parikh, N. S., Chaudhry, S. K., Chait, A., Allen, N. C., Navi, B. B., & Kamel, H. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-310181 · Cited by 22 · see citing works
Perez, D. L., Young, S., King, J. N., GUARINO, A. J., Dworetzky, B. A., Flaherty, A. W., Chemali, Z. N., Caplan, D. N., & Dickerson, B. C. (2016) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000106 · Cited by 22 · see citing works
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Fobian, A. D., & Elliott, L. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170190 · Cited by 134 · see citing works
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Weber, S., Bühler, J., Vanini, G., Loukas, S., Bruckmaier, R., & Aybek, S. (2023) · Brain · doi:10.1093/brain/awac442 · Cited by 63 · see citing works
Gao, S., Yu, D., Assink, M., Chan, K. L., Zhang, L., & Meng, X. (2024) · Trauma, Violence, & Abuse · doi:10.1177/15248380221147559 · Cited by 54 · see citing works
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- Authors
- Perez, D. L., Matin, N., Barsky, A., Costumero-Ramos, V., Makaretz, S. J., Young, S. S., Sepulcre, J., LaFranceJr, W. C., Keshavan, M. S., & Dickerson, B. C.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Perez, David L
- ORCID
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2017-04-17
- Volume
- 88
- Issue
- 6
- Pages
- 491-497
- ISSN
- 0022-3050 (ISSN-L)
- 1468-330X
- PMC
- PMC5497745
- OpenAlex
- W2605771372
- Semantic Scholar
- 2f8d75e31e53a404f8f100323eed528b3cd89209
- Cited by
- 114
- References
- 53
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 12 · 2022: 16 · 2021: 10 · 2020: 12 · 2019: 18 · 2018: 17 · 2017: 4
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Dupont Warren Fellowship
- MGH Physician-Scientist Development Award
- Sidney R. Baer Jr. Foundation
- National Center for Research Resources
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- conversion disorder, post-traumatic stress disorder, childhood abuse, anterior cingulate cortex, insula, brain volume, somatoform symptoms, hippocampus, life events, sex differences
- MeSH terms
- Adult, Cerebral Cortex, Child, Child Abuse, Conversion Disorder, Dominance, Cerebral, Female, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Life Change Events, Magnetic Resonance Imaging, Male, Middle Aged, Nervous System Diseases, Organ Size, Psychophysiologic Disorders, Statistics as Topic, Stress Disorders, Post-Traumatic, Imaging, Three-Dimensional, Gray Matter
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