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Cited by 216

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy

Open access
Sanderson, Ralph D., Elkin, Michael, Rapraeger, Alan C., Ilan, Neta, Vlodavsky, Israel·2017·The FEBS Journal
DOI 10.1111/febs.13932
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Abstract

Because of its impact on multiple biological pathways, heparanase has emerged as a major regulator of cancer, inflammation and other disease processes. Heparanase accomplishes this by degrading heparan sulfate which regulates the abundance and location of heparin‐binding growth factors thereby influencing multiple signaling pathways that control gene expression, syndecan shedding and cell behavior. In addition, heparanase can act via nonenzymatic mechanisms that directly activate signaling at the cell surface. Clinical trials testing heparanase inhibitors as anticancer therapeutics are showing early signs of efficacy in patients further emphasizing the biological importance of this enzyme. This review focuses on recent developments in the field of heparanase regulation of cancer and inflammation, including the impact of heparanase on exosomes and autophagy, and novel mechanisms whereby heparanase regulates tumor metastasis, angiogenesis and chemoresistance. In addition, the ongoing development of heparanase inhibitors and their potential for treating cancer and inflammation are discussed.

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Crossref · 10.1111/febs.13932

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Metadata

Authors
Sanderson, R. D., Elkin, M., Rapraeger, A. C., Ilan, N., & Vlodavsky, I.
Venue
The FEBS Journal
Publisher
Wiley
Published
2016-11-16
Volume
284
Issue
1
Pages
42-55
ISSN
  • 1742-464X (ISSN-L)
  • 1742-4658
DOI
10.1111/febs.13932
OpenAlex
W2539079898
Cited by
216
References
6
FWCI
14.28
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy. https://app.cochat.ai/papers/10.1111/febs.13932
The paper
Sanderson, R. D., Elkin, M., Rapraeger, A. C., Ilan, N., & Vlodavsky, I. (2017). Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy. The FEBS Journal. https://doi.org/10.1111/febs.13932

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.