The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Syndecans – key regulators of cell signaling and biological functions
Open accessAbstract
Syndecans are a small family of four transmembrane proteoglycans in mammals. They have similar structural organization, consisting of an N‐terminal ectodomain, single transmembrane domain and C‐terminal cytoplasmic domain. Over the years, the association between syndecans and the actin cytoskeleton has been established, which has consequences for the regulation of cell adhesion and migration. Specifically, ecto‐ and cytoplasmic domains are responsible for the interaction with extracellular matrix molecules and intracellular kinases, respectively. These interactions indicate syndecans as key molecules during cancer initiation and progression. Particularly syndecans interact with other cell surface receptors, such as growth factor receptors and integrins, which lead to activation of downstream signaling pathways, which are critical for the cellular behavior. Moreover, this review describes the key role of syndecans in intracellular calcium regulation and homeostasis. The syndecan‐mediated regulation of calcium metabolism is highly correlated with cells’ adhesion phenotype through the actin cytoskeleton and formation of junctions, with implications during differentiation and disease progression.
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Cites
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“Other downregulated genes include Mmp15 (Figure 5q), a metalloproteinase involved in extracellular matrix remodeling [29], and Sdc4 (Figure 5r), which is an important cell surface adhesion molecule involved in cell activation and migration [30].”
Background
Metadata
- Authors
- Afratis, N. A., Nikitovic, D., Multhaupt, H. A. B., Theocharis, A. D., Couchman, J. R., & Karamanos, N. K.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2016-11-18
- Volume
- 284
- Issue
- 1
- Pages
- 27-41
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2546451980
- Cited by
- 283
- References
- 100
- FWCI
- 16.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Afratis, N. A., Nikitovic, D., Multhaupt, H. A. B., Theocharis, A. D., Couchman, J. R., & Karamanos, N. K. (2017). Syndecans – key regulators of cell signaling and biological functions. The FEBS Journal. https://doi.org/10.1111/febs.13940
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
