The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
A guide to chemokines and their receptors
Open accessAbstract
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are best known for their ability to stimulate the migration of cells, most notably white blood cells (leukocytes). Consequently, chemokines play a central role in the development and homeostasis of the immune system, and are involved in all protective or destructive immune and inflammatory responses. Classically viewed as inducers of directed chemotactic migration, it is now clear that chemokines can stimulate a variety of other types of directed and undirected migratory behavior, such as haptotaxis, chemokinesis, and haptokinesis, in addition to inducing cell arrest or adhesion. However, chemokine receptors on leukocytes can do more than just direct migration, and these molecules can also be expressed on, and regulate the biology of, many nonleukocytic cell types. Chemokines are profoundly affected by post‐translational modification, by interaction with the extracellular matrix (ECM), and by binding to heptahelical ‘atypical’ chemokine receptors that regulate chemokine localization and abundance. This guide gives a broad overview of the chemokine and chemokine receptor families; summarizes the complex physical interactions that occur in the chemokine network; and, using specific examples, discusses general principles of chemokine function, focusing particularly on their ability to direct leukocyte migration.
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Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting
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Korbecki, J., Simińska, D., Gąssowska-Dobrowolska, M., Listos, J., Gutowska, I., Chlubek, D., & Baranowska-Bosiacka, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910701 · Cited by 380
Metadata
- Authors
- Hughes, C. E., & Nibbs, R. J. B.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2018-04-24
- Volume
- 285
- Issue
- 16
- Pages
- 2944-2971
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2797069917
- Cited by
- 1,412
- References
- 23
- FWCI
- 25.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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