Effect of renin–angiotensin system on senescence
Open accessAbstract
The renin–angiotensin system (RAS) plays crucial roles in the control of blood pressure and sodium homeostasis. Moreover, RAS also acts as a key player in cell and organ senescence, mainly by activation of the classical axis of angiotensin (Ang) converting enzyme (ACE)/Ang II/Ang II type 1 receptor via overproduction of reactive oxygen species. Overactivation of the classical RAS axis induces organ dysfunction in the vasculature, brain, kidney and skeletal muscle, resulting in atherosclerosis, stroke, chronic kidney disease and sarcopenia. Moreover, RAS has been shown to regulate lifespan, using gene‐modification models. Recently, mice lacking the Ang II type 1 receptor were shown to exhibit an increase in lifespan compared with control mice. Here, the effect of RAS on age‐related tissue dysfunction in several organs is reviewed, including not only the classical axis but also protective functions of RAS such as the ACE2/Ang (1–7)/Mas axis. Geriatr Gerontol Int 2020; ••: ••–•• .
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Increased angiotensin II concentrations mediated by the actions of SARS-CoV-2 on ACE2 receptor-Ang II signaling may up-regulate ROS and cellular senescence pathways.
“Aside from the contribution of neutrophils and other cell types to ROS generation, increased angiotensin (Ang) II concentrations mediated by the actions of SARS-CoV-2 on ACE2 receptor–Ang II signaling may up-regulate ROS and cellular senescence pathways (64).”
From Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19 (2021) · cites this paper as [64]
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- Authors
- Mogi, M.
- Affiliations
- Ehime University (JP)
- Corresponding author
- Mogi, Masaki
- ORCID
- Mogi, Masaki
- Venue
- Geriatrics & Gerontology International
- Publisher
- Wiley
- Published
- 2020-04-29
- Volume
- 20
- Issue
- 6
- Pages
- 520-525
- ISSN
- 1444-1586 (ISSN-L)
- 1447-0594
- OpenAlex
- W3020455905
- Cited by
- 48
- References
- 85
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 8
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Geriatrics and gerontology international/Geriatrics & gerontology international (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- renin-angiotensin system, cellular senescence, aging, angiotensin II type 1 receptor, angiotensin-converting enzyme, ACE2/Ang-(1-7)/Mas axis, reactive oxygen species, lifespan, atherosclerosis, stroke, chronic kidney disease, sarcopenia
- MeSH terms
- Aging, Angiotensin I, Angiotensin II, Animals, Humans, Peptidyl-Dipeptidase A, Longevity, Peptide Fragments, Renin-Angiotensin System, Signal Transduction, Cellular Senescence, Oxidative Stress, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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