The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part III
Abstract
Vagus nerve stimulation (VNS) is currently undergoing multiple trials to explore its potential for various clinical disorders. To date, VNS has been approved for the treatment of refractory epilepsy and depression. It exerts antiepileptic or antiepileptogenic effect possibly through neuromodulation of certain monoamine pathways. Beyond epilepsy, VNS is also under investigation for the treatment of inflammation, asthma, and pain. VNS influences the production of inflammatory cytokines to dampen the inflammatory response. It triggers the systemic release of catecholamines that alleviates the asthma attack. VNS induces antinociception by modulating multiple pain‐associated structures in the brain and spinal cord affecting peripheral/central nociception, opioid response, inflammation process, autonomic activity, and pain‐related behavior. Progression in VNS clinical efficacy over time suggests an underlying disease‐modifying neuromodulation, which is an emerging field in neurology. With multiple potential clinical applications, further development of VNS is encouraging.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154 · cited 4×
“VN senses inflammation and dampens the inflammatory response by influencing the hypothalamicpituitary-adrenal axis and modulating the autonomic system that controls key immune organs, such as the spleen, adrenal glands, and possibly bone marrow.(27,28) The spleen is the central organ in the inflammatory reflex and the…”
BackgroundInfluentialVagus nerve stimulation therapy for partial-onset seizures: A randomized active-control trial
Handforth, A., DeGiorgio, C. M., Schachter, S. C., Uthman, B. M., Naritoku, D. K., Tecoma, E. S., Henry, T. R., Collins, S. D., Vaughn, B. V., Gilmartin, R. C., et al. (1998) · Neurology · doi:10.1212/wnl.51.1.48 · Cited by 1,107
The vagus nerve and the inflammatory reflex – linking immunity and metabolism
Pavlov, V. A., & Tracey, K. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.189 · Cited by 1,040
Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy
Morris, G. L., Mueller, W. M., & The Vagus Nerve Stimulation Study Group E–E (1999) · Neurology · doi:10.1212/wnl.53.8.1731 · Cited by 724
Ben‐Menachem, E., Mañon‐Espaillat, R., Ristanovic, R., Wilder, B. J., Stefan, H., Mirza, W., Tarver, W. B., Wernicke, J. F., & First International Vagus Nerve Stimulation Study Group (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02482.x · Cited by 683
Sepsis: Current Dogma and New Perspectives
Deutschman, C. S., & Tracey, K. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.001 · Cited by 677
Dopamine mediates vagal modulation of the immune system by electroacupuncture
Torres-Rosas, R., Yehia, G., Peña, G., Mishra, P., del Rocio Thompson-Bonilla, M., Moreno-Eutimio, M. A., Arriaga-Pizano, L. A., Isibasi, A., & Ulloa, L. (2014) · Nature Medicine · doi:10.1038/nm.3479 · Cited by 630
Locus Coeruleus Lesions Suppress the Seizure‐Attenuating Effects of Vagus Nerve Stimulation
Krahl, S. E., Clark, K. B., Smith, D. C., & Browning, R. A. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01155.x · Cited by 555
Non-invasive Vagus Nerve Stimulation in Healthy Humans Reduces Sympathetic Nerve Activity
Clancy, J. A., Mary, D. A., Witte, K. K., Greenwood, J. P., Deuchars, S. A., & Deuchars, J. (2014) · Brain Stimulation · doi:10.1016/j.brs.2014.07.031 · Cited by 539
Cited by
Seizure prediction – ready for a new era
Kuhlmann, L., Lehnertz, K., Richardson, M. P., Schelter, B., & Zaveri, H. P. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0055-2 · Cited by 450
Yap, J. Y. Y., Keatch, C., Lambert, E., Woods, W., Stoddart, P. R., & Kameneva, T. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00284 · Cited by 432
The vagus nerve in appetite regulation, mood, and intestinal inflammation
Browning, K. N., Verheijden, S., & Boeckxstaens, G. E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.046 · Cited by 361
Breath of Life: The Respiratory Vagal Stimulation Model of Contemplative Activity
Gerritsen, R. J. S., & Band, G. P. H. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00397 · Cited by 342
“The pulmonary efferents regulate airway size and thus volume, they lower respiration rate and indirectly endocrine secretion (Yuan and Silberstein, 2016a).”
Role of the vagus nerve in the development and treatment of diet‐induced obesity
de Lartigue, G. (2016) · The Journal of Physiology · doi:10.1113/jp271538 · Cited by 238
Metadata
- Authors
- Yuan, H., & Silberstein, S. D.
- Venue
- Headache: The Journal of Head and Face Pain
- Publisher
- Wiley
- Published
- 2015-09-14
- Volume
- 56
- Issue
- 3
- Pages
- 479-490
- ISSN
- 0017-8748 (ISSN-L)
- 1526-4610
- OpenAlex
- W1937423926
- Cited by
- 381
- References
- 130
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part III. https://app.cochat.ai/papers/10.1111/head.12649
- The paper
- Yuan, H., & Silberstein, S. D. (2016). Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part III. Headache: The Journal of Head and Face Pain. https://doi.org/10.1111/head.12649
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
