Cited by 408NF-κB Signaling PathwaysT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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NF‐κB: roles and regulation in different CD 4+ T‐cell subsets

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Oh, Hyunju, Ghosh, Sankar·2013·Immunological Reviews

DOI 10.1111/imr.12033PMC PMC3576882

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Abstract

Summary: The nuclear factor‐κB (NF‐κB) family of transcription factors plays important roles in various biological processes including apoptosis, stress response, immunity, and inflammation. NF‐κB signaling is involved in both immune cell development and function, and it is critical in modulation of the immune response through the transcriptional regulation of cytokine and chemokine expression. An area of great interest in T‐cell‐mediated adaptive immunity is the ability of naive CD 4+ T cells generated in the thymus to differentiate into various subsets including T‐helper 1 (Th1), Th2, Th17, Th9, follicular helper T (Tfh), Th22, and regulatory T (Treg) cells, upon encountering different pathogens and microenvironments. In this review, we discuss the role of NF‐κB pathway in the development and functional divergence of the different helper T‐cell subsets as well as in regulatory T cells.

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BackgroundInfluential
Roles for Helper T Cell Lineage-Specifying Transcription Factors in Cellular Specialization
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Authors: Oh, H., & Ghosh, S.
Affiliations: Department of Microbiology and Immunology Columbia University New York NY
Columbia University (US)
Corresponding author: Ghosh, Sankar
ORCID: Ghosh, Sankar
Venue: Immunological Reviews
Publisher: Wiley
Published: 2013-02-13
Volume: 252
Issue: 1
Pages: 41-51
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/imr.12033
PMC: PMC3576882
OpenAlex: W2070085523
Cited by: 408
References: 71
Citations by year: 2026: 16 · 2025: 36 · 2024: 43 · 2023: 46 · 2022: 43 · 2021: 39 · 2020: 28 · 2019: 25 · 2018: 27 · 2017: 26 · 2016: 26 · 2015: 24 · 2014: 21 · 2013: 7
FWCI: 2.15
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service (R37-33443, R01-68977)
National Institute of Allergy and Infectious Diseases (R01AI068977, R37AI033443)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: NF-κB signaling, CD4+ T cells, T helper cell differentiation, Th1 cells, Th2 cells, Th17 cells, Th9 cells, Th22 cells, T follicular helper cells, regulatory T cells, transcriptional regulation, cytokine and chemokine expression, adaptive immunity, inflammation
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Lymphocyte Activation, Transcription Factors, Transcription, Genetic, Signal Transduction, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Cytokines, NF-kappa B, Mice, Adaptive Immunity

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NF‐κB: roles and regulation in different CD 4+ T‐cell subsets

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