The DOI matches its Crossref record, with a small difference in title or year; 71 of the 71 references it cites were found in a registry or an index.
NF‐κB: roles and regulation in different CD 4+ T‐cell subsets
Open accessAbstract
Summary: The nuclear factor‐κB (NF‐κB) family of transcription factors plays important roles in various biological processes including apoptosis, stress response, immunity, and inflammation. NF‐κB signaling is involved in both immune cell development and function, and it is critical in modulation of the immune response through the transcriptional regulation of cytokine and chemokine expression. An area of great interest in T‐cell‐mediated adaptive immunity is the ability of naive CD 4+ T cells generated in the thymus to differentiate into various subsets including T‐helper 1 (Th1), Th2, Th17, Th9, follicular helper T (Tfh), Th22, and regulatory T (Treg) cells, upon encountering different pathogens and microenvironments. In this review, we discuss the role of NF‐κB pathway in the development and functional divergence of the different helper T‐cell subsets as well as in regulatory T cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Other studies have also shown that FOXK2 affects the activation of T lymphocytes77,78 and revealed the essential roles of NR4A1 in regulatory T cell differentiation79,80, suggesting that the identified TFs have important roles in naive CD4+ T cell response upon TCR stimulation.”
From Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data (2025) · cites this paper as [78]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608 · cited 1×
“Since the original discovery of CD4CD25 Treg cells by Sakaguchi and colleagues (14), there has been much progress in understanding the role of Treg cells in immune homeostasis and function.”
BackgroundCTLA-4 Control over Foxp3 + Regulatory T Cell Function
Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738 · cited 1×
“Also, Tfh cells express high level of ICOS, and the resulting costimulatory signal through the interaction between T-cell ICOS and B-cell ICOSL is critical for B-cell maturation (42).”
BackgroundDeaglio, S., Dwyer, K. M., Gao, W., Friedman, D. J., Usheva, A., Erat, A., Chen, J., Enjyoji, K., Linden, J. M., Oukka, M., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062512 · Cited by 2,613
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
Crosstalk in NF-κB Signaling Pathways
Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942
Self-citationTrans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
Qureshi, O. S., Zheng, Y., Nakamura, K., Attridge, K., Manzotti, C., Schmidt, E. M., Baker, J., Jeffery, L. E., Kaur, S., Briggs, Z., et al. (2011) · Science · doi:10.1126/science.1202947 · Cited by 1,860
Modulation of tryptophan catabolism by regulatory T cells
Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M., & Puccetti, P. (2003) · Nature Immunology · doi:10.1038/ni1003 · Cited by 1,375
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
Asano, M., Toda, M., Sakaguchi, N., & Sakaguchi, S. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.387 · Cited by 1,328
Flagged first, then by citations
Cited by
Sorted by citations
NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791
JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression
Owen, K. L., Brockwell, N. K., & Parker, B. S. (2019) · Cancers · doi:10.3390/cancers11122002 · Cited by 728
NF-κB in inflammation and cancer
Mao, H., Zhao, X., & Sun, S. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01310-w · Cited by 601
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
Hwang, J.-R., Byeon, Y., Kim, D., & Park, S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0435-8 · Cited by 481
Pathogenesis of allergic diseases and implications for therapeutic interventions
Wang, J., Zhou, Y., Zhang, H., Hu, L., Liu, J., Wang, L., Wang, T., Zhang, H., Cong, L., & Wang, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01344-4 · Cited by 431
NF-κB in inflammation and renal diseases
Zhang, H., & Sun, S.-C. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0056-4 · Cited by 383
NF ‐κB and HIF crosstalk in immune responses
D’Ignazio, L., Bandarra, D., & Rocha, S. (2015) · FEBS Journal · doi:10.1111/febs.13578 · Cited by 383
NF-kappaB: Two Sides of the Same Coin
Pires, B. R. B., Silva, R. C. M. C., Ferreira, G. M., & Abdelhay, E. S. F. W. (2018) · Genes · doi:10.3390/genes9010024 · Cited by 243
“Functions: Supports the activity of different T CD4+ cell sub-types, such as T helper 1 (Th1) and T regulatory cells (Tregs) [43].”
BackgroundNF-κB control of T cell development
Gerondakis, S., Fulford, T. S., Messina, N. L., & Grumont, R. J. (2013) · Nature Immunology · doi:10.1038/ni.2785 · Cited by 250
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma
Seumois, G., Ramírez-Suástegui, C., Schmiedel, B. J., Liang, S. Y., Peters, B., Sette, A., & Vijayanand, P. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba6087 · Cited by 212
“Prosurvival factors included several in the nuclear factor B signaling pathway, including NFKBID, NIPAI, MAP3K8, FOSL2, NEDD9 (89), ZEB2, BCL2A1 (90), BIRC3 (91), DUSP4/MKP-2 (92, 93), and CFLAR (cFLIP/CASPER) (94).”
BackgroundNotch in T Cell Differentiation: All Things Considered
Amsen, D., Helbig, C., & Backer, R. A. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.10.007 · Cited by 187
NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development
Ratnam, N. M., Peterson, J. M., Talbert, E. E., Ladner, K. J., Rajasekera, P. V., Schmidt, C. R., Dillhoff, M. E., Swanson, B. J., Haverick, E. N., Kladney, R. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci91561 · Cited by 173
Interleukin-17 in human inflammatory diseases
Shabgah, A. G., Fattahi, E., & Shahneh, F. Z. (2014) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2014.40954 · Cited by 181
NF-κB pathways in hematological malignancies
Gasparini, C., Celeghini, C., Monasta, L., & Zauli, G. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1545-4 · Cited by 170
Klemann, C., Camacho-Ordóñez, N., Yang, L., Eskandarian, Z., Rojas‐Restrepo, J., Frede, N., Bulashevska, A., Heeg, M., Al-Ddafari, M. S., Premm, J., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00297 · Cited by 155
Identification of environmental factors that promote intestinal inflammation
Sanmarco, L. M., Chao, C., Wang, Y., Kenison, J. E., Li, Z., Rone, J. M., Rejano-Gordillo, C. M., Polonio, C. M., Gutiérrez‐Vázquez, C., Piester, G., et al. (2022) · Nature · doi:10.1038/s41586-022-05308-6 · Cited by 158
NF-κB: master regulator of cellular responses in health and disease
Hoffmann, A., Cheng, G., & Baltimore, D. (2025) · Immunity & Inflammation · doi:10.1007/s44466-025-00014-0 · Cited by 173
Immune system adaptation during gender-affirming testosterone treatment
Lakshmikanth, T., Consiglio, C. R., Sardh, F., Forlin, R., Wang, J., Tan, Z., Barcenilla, H., Rodriguez, L., Sugrue, J. A., Noori, P., et al. (2024) · Nature · doi:10.1038/s41586-024-07789-z · Cited by 148
“…binding sites (data not shown), indicating that the canonical NFκB pathway is induced epigenetically in T/NK cells following testosterone treatment, possibly as a consequence of elevated TNF responses by myeloid cells, with broad functional implications for T/NK cell function and proliferation 32 .”
BackgroundLaurindo, L. F., Dias, J. A., Araújo, A. C., Pomini, K. T., Galhardi, C. M., Detregiachi, C. R. P., Haber, L. S. D. A., Roque, D. D., Bechara, M. D., de Castro, M. V. M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1305933 · Cited by 156
Hypoxia‐Inducible Exosomes Facilitate Liver‐Tropic Premetastatic Niche in Colorectal Cancer
Sun, H., Meng, Q., Shi, C., Yang, H., Li, X., Wu, S., Familiari, G., Relucenti, M., Aschner, M., Wang, X., et al. (2021) · Hepatology · doi:10.1002/hep.32009 · Cited by 144
Lactate oxidase nanocapsules boost T cell immunity and efficacy of cancer immunotherapy
Cao, Z., Xu, D., Harding, J., Chen, W., Liu, X., Wang, Z., Wang, L., Qi, T., Chen, S., Guo, X., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add2712 · Cited by 145
Gut microbiota in pre-clinical rheumatoid arthritis: From pathogenesis to preventing progression
Lin, L., Zhang, K., Xiong, Q., Zhang, J., Cai, B., Huang, Z., Yang, B., Wei, B., Chen, J., & Niu, Q. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103001 · Cited by 142
A population-level digital histologic biomarker for enhanced prognosis of invasive breast cancer
Amgad, M., Hodge, J. M., Elsebaie, M. A. T., Bodelon, C., Puvanesarajah, S., Gutman, D. A., Siziopikou, K. P., Goldstein, J. A., Gaudet, M. M., Teras, L. R., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02643-7 · Cited by 137
“In addition, GSEA using the Hallmarks set showed that chromatin clumping of TILs was positively associated with protein secretion, probably because of B cells and plasma cells, and inversely associated with TNF-α signaling via NF-kB, a critical pathway in T cell activation 69,70,74,75 .”
Song, N., Thaiss, F., & Guo, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00815 · Cited by 127
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
Mikami, N., Kawakami, R., Chen, K. Y., Sugimoto, A., Ohkura, N., & Sakaguchi, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922600117 · Cited by 119
“With our observation of a lower level of NF-κ B signaling-related genes expressed in both stimulated CD28( − ) iTregs and nTregs, it remains to be investigated whether excessive NF-κ B signaling may preferentially polarize Tconvs toward effector T cell differentiation and away from pTregs (48, 49).”
Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data
Yuan, Q., & Duren, Z. (2025) · Nature Biotechnology · doi:10.1038/s41587-024-02182-7 · Cited by 118
Zeligs, K., Neuman, M. K., & Annunziata, C. M. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1374 · Cited by 117
Raimondo, S., Urzì, O., Meraviglia, S., Simone, M. D., Corsale, A. M., Ganji, N. R., Piccionello, A. P., Polito, G., Presti, E. L., Dieli, F., et al. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17404 · Cited by 125
Small molecules in the treatment of COVID-19
Lei, S., Chen, X., Wu, J., Duan, X., & Men, K. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01249-8 · Cited by 119
Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease
Davies, D. A., Adlimoghaddam, A., & Albensi, B. C. (2021) · Cells · doi:10.3390/cells10081884 · Cited by 112
NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms
Yu, L., Li, L., Medeiros, L. J., & Young, K. H. (2017) · Blood Reviews · doi:10.1016/j.blre.2016.10.001 · Cited by 105
NF-κB and Its Role in Checkpoint Control
Betzler, A. C., Theodoraki, M., Schuler, P. J., Döscher, J., Laban, S. A., Hoffmann, T. K., & Brunner, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113949 · Cited by 106
Masenga, S. K., Mweene, B. C., Luwaya, E. L., Muchaili, L., Chona, M., & Kirabo, A. (2023) · Cells · doi:10.3390/cells12101351 · Cited by 114
Harusato, A., Abo, H., Ngo, V. L., Yi, S. W., Mitsutake, K., Osuka, S., Kohlmeier, J. E., Li, J., Gewirtz, A. T., Nusrat, A., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.21 · Cited by 104
Morris, G., Bortolasci, C. C., Puri, B. K., Marx, W., O'Neil, A. E., Athan, E., Walder, K. R., Berk, M., OLIVE, L. S., Carvalho, A. F., et al. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155593 · Cited by 101
NF-κB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders?
Roberti, A., Chaffey, L., & Greaves, D. R. (2022) · Biology · doi:10.3390/biology11030372 · Cited by 107
Nicolay, J., Müller-Decker, K., Schroeder, A. E., Brechmann, M., Möbs, M., Géraud, C., Assaf, C., Goerdt, S., Krammer, P., & Gülow, K. (2016) · Blood · doi:10.1182/blood-2016-01-694117 · Cited by 98
“As opposed to restingT cells (D0), activatedTcells (D6) dependonNF-kB.(37)Upon DMF treatment, activated, but not resting, healthy T cells were shown to undergo cell death, reflecting selective cell death induction by DMF in cells with high NF-kB activity(18,21,37) (supplemental Figure 1C).”
BackgroundNuclear Factor-kappaB in Autoimmunity: Man and Mouse
Miraghazadeh, B., & Cook, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00613 · Cited by 98
Targeting the NF-κB pathway as a potential regulator of immune checkpoints in cancer immunotherapy
Ebrahimi, N., Abdulwahid, A. R. R., Mansouri, A., Karimi, N., Bostani, R. J., Beiranvand, S., Adelian, S., Khorram, R., Vafadar, R., Hamblin, M. R., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05098-8 · Cited by 101
Nazerian, Y., Ghasemi, M., Yassaghi, Y., Nazerian, A., & Hashemi, S. M. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109428 · Cited by 96
“Activation of the NF-κB pathway is also involved in regulating CD4 T-cell differentiation following TCR activation and also via regulating the cytokine production in innate immune response [72].”
BackgroundInflammation and pancreatic cancer: An updated review
Shadhu, K., & Xi, C. (2018) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_390_18 · Cited by 97
“[9,10] NF‐κB is a transcription factor known to participate in the communication between tumor and immune cells.[11] The NF‐κB subunit p65 is ubiquitously expressed in mammalian cells, and when constitutively activated, it is associated with cellular transformation.”
BackgroundLkb1 maintains Treg cell lineage identity
Wu, D., Luo, Y., Guo, W., Niu, Q., Xue, T., Yang, F., Sun, X., Chen, S., Liu, Y., Liu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15876 · Cited by 93
Shi, Y., Zhao, T., Yang, X., Sun, B., Li, Y., Duan, J., & Sun, Z. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.09.085 · Cited by 92
Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma
Seumois, G., Zapardiel‐Gonzalo, J., White, B. M., Singh, D. K., Schulten, V. M. J., Dillon, M., Hinz, D., Broide, D. H., Sette, A., Peters, B., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600397 · Cited by 93
STIM- and Orai-mediated calcium entry controls NF-κB activity and function in lymphocytes
Berry, C. T., May, M. J., & Freedman, B. D. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.07.003 · Cited by 98
A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo
Bending, D., Martín, P. P., Paduraru, A., Ducker, C. B., Marzaganov, E., Laviron, M., Kitano, S., Miyachi, H., Crompton, T., & Ono, M. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201711048 · Cited by 94
“A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo Journal of Cell Biology https://doi.org/10.1083/jcb.201711048 2 (Oh and Ghosh, 2013), but their effects on T cell differentiation over the timescale of hours and days are obscure.”
MethodInfluentialTargeting Undruggable Transcription Factors with PROTACs: Advances and Perspectives
Li, Y., Song, J. H., Zhou, P., Zhou, J., & Xie, S. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00691 · Cited by 91
Selenium and Selenoproteins in Gut Inflammation—A Review
Nettleford, S. K., & Prabhu, K. S. (2018) · Antioxidants · doi:10.3390/antiox7030036 · Cited by 87
Yoon, S., Mitra, S., Wyse, C. A., Alnabulsi, A., Zou, J., Weerdenburg, E. M., van der Sar, A. M., Wang, D., Secombes, C. J., & Bird, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126378 · Cited by 87
Delagreverie, H. M., Delaugerre, C., Lewin, S. R., Deeks, S. G., & Li, J. Z. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw189 · Cited by 82
“Toll-like receptor (TLR) agonists, which stimulate immune signaling pathways in T cells, leading to transcriptional modifications and NF-κB activation [9, 10].”
BackgroundRole and mechanisms of the NF-ĸB signaling pathway in various developmental processes
Liu, P., Li, Y., Wang, W., Bai, Y., Jia, H., Yuan, Z., & Zhonghua, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113513 · Cited by 92
Targeting ubiquitin signaling for cancer immunotherapy
Zhou, X., & Sun, S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00421-2 · Cited by 87
GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis
Hussman, J. P., Beecham, A. H., Schmidt, M. A., Martin, E. R., McCauley, J. L., Vance, J. M., Haines, J. L., & Pericak‐Vance, M. A. (2016) · Genes and Immunity · doi:10.1038/gene.2016.23 · Cited by 80
Wang, T., Husain, M., Hong, S., & Holland, J. W. (2014) · European Journal of Immunology · doi:10.1002/eji.201344273 · Cited by 77
Liu, J., Wang, S., Zhang, Q., Li, X., & Xu, S. (2019) · Metallomics · doi:10.1039/c9mt00216b · Cited by 75
Escape from X chromosome inactivation and female bias of autoimmune diseases
Mousavi, M. J., Mahmoudi, M., & Ghotloo, S. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00256-1 · Cited by 81
NF-κB, a culprit of both inflamm-ageing and declining immunity?
Songkiatisak, P., Rahman, S. M. T., Aqdas, M., & Sung, M. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00277-w · Cited by 81
NF-κB signaling in rheumatoid arthritis with focus on fibroblast-like synoviocytes
Samimi, L. N., Farhadi, E., Tahmasebi, M. N., Jamshidi, A., Vaziri, A. S., & Mahmoudi, M. (2020) · Autoimmunity Highlights · doi:10.1186/s13317-020-00135-z · Cited by 80
Zayed, A., Al-Saedi, D. A., Mensah, E. O., Kanwugu, O. N., Adadi, P., & Ulber, R. (2023) · Marine Drugs · doi:10.3390/md22010029 · Cited by 78
Lesovaya, E. A., Yemelyanov, A. Y., Swart, A. C., Swart, P., Haegeman, G., & Budunova, I. V. (2015) · Oncotarget · doi:10.18632/oncotarget.5078 · Cited by 73
The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways
Yuan, X., Kang, Y., Zhuo, C., Huang, X., & Song, X. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.152 · Cited by 77
Liu, X., Berry, C. T., Ruthel, G. T., Madara, J. J., Macgillivray, K., Gray, C. M., Madge, L. A., McCorkell, K. A., Beiting, D. P., Hershberg, U., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.713008 · Cited by 73
CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation
Kulkarni, N., Meitei, H. T., Sonar, S. A., Sharma, P., Mujeeb, V. R., Srivastava, S., Boppana, R., & Lal, G. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.10.013 · Cited by 73
Digital signaling decouples activation probability and population heterogeneity
Kellogg, R., Tian, C., Tomasz Lipniacki, B., Quake, S. R., & Tay, S. (2015) · eLife · doi:10.7554/elife.08931 · Cited by 69
“T- and B-cell receptor binding with antigen-MHC triggers digital activation and cell fate control via NF-κB (Kingeter et al., 2010; Oh and Ghosh, 2013; Gerondakis et al., 2014; Shinohara et al., 2014).”
BackgroundMacrophages in pancreatic cancer: An immunometabolic perspective
Yang, J. M., Li, Y., Sun, Z., & Zhan, H. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.10.029 · Cited by 72
A complex issue on CD 4+ T‐cell subsets
Jiang, S., & Dong, C. (2013) · Immunological Reviews · doi:10.1111/imr.12041 · Cited by 78
Samotij, D., Nedoszytko, B., Bartosińska, J., Batycka-Baran, A., Czajkowski, R., Dobrucki, I. T., Dobrucki, L. W., Górecka-Sokołowska, M., Janaszak‐Jasiecka, A., Krasowska, D., et al. (2020) · Advances in Dermatology and Allergology · doi:10.5114/ada.2020.94832 · Cited by 69
Inflammation: A bridge between diabetes and COVID-19, and possible management with sitagliptin
Mozafari, N., Azadi, S., Mehdi-Alamdarlou, S., Ashrafi, H., & Azadi, A. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110111 · Cited by 66
Schmidt, C., Berger, T., Groettrup, M., & Basler, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02386 · Cited by 65
Combined exposure to formaldehyde and PM2.5: Hematopoietic toxicity and molecular mechanism in mice
Ge, J., Yang, H., Lu, X., Wang, S., Zhao, Y. S., Huang, J., Xi, Z., Zhang, L., & Li, R. (2020) · Environment International · doi:10.1016/j.envint.2020.106050 · Cited by 64
“Some recent studies have found that NF-κB has a crucial role in the development of Th2 and Th17 cells, mainly in the regulation of IL-4 and IL-17A secretion (Oh and Ghosh, 2013).”
BackgroundLi, Y., Wang, H., Zhou, X., Xie, X., Chen, X. '., Jie, Z., Zou, Q., Hu, H., Zhu, L., Cheng, X., et al. (2016) · Scientific Reports · doi:10.1038/srep22115 · Cited by 63
Enwere, E. K., LaCasse, E. C., Adam, N., & Korneluk, R. G. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00034 · Cited by 65
FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti‐inflammatory drug target
Kästle, M., Kistler, B., Lamla, T., Bretschneider, T., Lamb, D. J., Nicklin, P. L., & Wyatt, D. (2018) · European Journal of Immunology · doi:10.1002/eji.201847699 · Cited by 62
García‐Díaz, N., Piris, M. A., Ortiz-Romero, P. L., & Vaque, J. P. (2021) · Cancers · doi:10.3390/cancers13081931 · Cited by 65
“Then, p52 heterodimerizes with RelB and translocates to the nucleus (reviewed in [71]).”
BackgroundThe Role of Nuclear Factor Kappa B (NF-κB) in Development and Treatment of COVID-19: Review
Gudowska-Sawczuk, M., & Mroczko, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095283 · Cited by 59
“Therefore, dysregulation of NF-κB can lead to an uncontrolled and pathogenic inflammatory response [12,15].”
BackgroundMannino, M. P., & Hart, G. W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.828648 · Cited by 63
Gammaherpesviruses and Pulmonary Fibrosis
Williams, K. J. (2014) · Veterinary Pathology · doi:10.1177/0300985814521838 · Cited by 58
Li, S. X., Barrett, B. S., Heilman, K. J., Messer, R. J., Liberatore, R. A., Bieniasz, P. D., Kassiotis, G., Hasenkrug, K. J., & Santiago, M. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400490 · Cited by 57
Zhao, M., Chen, H., Ding, Q., Xu, X., Yu, B., & Huang, Z. (2016) · Scientific Reports · doi:10.1038/srep38619 · Cited by 57
Gambhir, L., Checker, R., Sharma, D., Thoh, M., Patil, A., Degani, M. S., Gota, V., & Sandur, S. K. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.09.014 · Cited by 56
Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
Sehnert, B., Burkhardt, H., Dübel, S., & Voll, R. E. (2020) · Cells · doi:10.3390/cells9071627 · Cited by 57
Thakore, P. I., Schnell, A., Zhao, M., Huang, L., Hou, Y., Christian, E., Zaghouani, S., Wang, C., Singh, V., Ma, S., et al. (2022) · doi:10.1101/2022.02.26.482041 · Cited by 57
Immunometabolism: signaling pathways, homeostasis, and therapeutic targets
Xu, R., He, X., Xu, J., Yu, G., & Wu, Y. (2024) · MedComm · doi:10.1002/mco2.789 · Cited by 64
Yu, J., Zhou, X.-F., Nakaya, M., Jin, W., Cheng, X.-H., & Sun, S.-C. (2014) · Journal of Immunology · doi:10.4049/jimmunol.1303237 · Cited by 54
NF-κB dynamics in the language of immune cells
Aqdas, M., & Sung, M. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.11.005 · Cited by 55
Mingueneau, M., Krishnaswamy, S., Spitzer, M. H., Bendall, S. C., Stone, E. L., Hedrick, S. Μ., Pe’er, D., Mathis, D. J., Nolan, G. P., & Benoist, C. O. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419337111 · Cited by 51
“CD4SP thymocytes, CD44hi effector/memory CD4+ T cells, and CD25+ CD4+ Tregs showed the same B6g7 vs. NOD differential of the ERK1/2–S6–CREB signaling module and a more subtle difference in pCD3ζ (Fig.”
BackgroundInfluentialWu, X., Yang, Y., Li, W., Cheng, Y., Li, X., Huang, C., Meng, X., Wu, B., Liu, X., Zhang, L., et al. (2016) · Scientific Reports · doi:10.1038/srep18685 · Cited by 53
Wang, Y., Zhao, H., Shao, Y., Liu, J., Li, J., & Xing, M. (2017) · Oncotarget · doi:10.18632/oncotarget.21463 · Cited by 53
The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability
Ronin, É., di Ricco, M. L., Vallion, R., Divoux, J., Kwon, H., Grégoire, S., Collares, D., Rouers, A., Baud, V., Benoist, C. O., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02487 · Cited by 58
Matson, C. A., Choi, S., Livák, F., Zhao, B., Mitra, A., Love, P. E., & Singh, N. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922525117 · Cited by 53
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis
Jie, Z., Yang, J.-Y., Gu, M., Wang, H., Xie, X., Li, Y., Liu, T., Zhu, L., Shi, J., Zhang, L., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0206-z · Cited by 50
Azhary, K. E., Jouti, N. T., Khachibi, M. E., Moutia, M., Tabyaoui, I., Elhou, A., Achtak, H., Nadifi, S., Habti, N., & Badou, A. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1569-7 · Cited by 52
“NF-κB is also required for activated T cell survival, proliferation and cytokine gene expression [42].”
BackgroundContext-specific effects of genetic variants associated with autoimmune disease
Jonkers, I. H., & Wijmenga, C. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx254 · Cited by 53
Cooperation between T cell receptor and Toll-like receptor 5 signaling for CD4 + T cell activation
Rodríguez-Jorge, O., Kempis-Calanis, L. A., Abou-Jaoudé, W., Gutiérrez‐Reyna, D. Y., Hernandez, C., Ramírez-Pliego, O., Thomas‐Chollier, M., Spicuglia, S., Santana, M. A., & Thieffry, D. (2019) · Science Signaling · doi:10.1126/scisignal.aar3641 · Cited by 46
TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis
Chen, X., Nie, Y., Xiao, H., Bian, Z., Scarzello, A. J., Song, N., Trivett, A. L., Yang, D., & Oppenheim, J. J. (2016) · Scientific Reports · doi:10.1038/srep32834 · Cited by 50
O-GlcNAcylation regulation of cellular signaling in cancer
Ciraku, L., Esquea, E. M., & Reginato, M. J. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110201 · Cited by 51
Chen, X., Willette‐Brown, J., Wu, X., Hu, Y. N., Howard, O. M. Z., Hu, Y., & Oppenheim, J. J. (2014) · The FASEB Journal · doi:10.1096/fj.14-259564 · Cited by 49
Update on Vitamin E and Its Potential Role in Preventing or Treating Bronchopulmonary Dysplasia
Stone, C. A., McEvoy, C. T., Aschner, J. L., Kirk, A., Rosas‐Salazar, C., Cook‐Mills, J. M., Moore, P. E., Walsh, W. F., & Hartert, T. V. (2018) · Neonatology · doi:10.1159/000487388 · Cited by 49
B cell MHC class II signaling: A story of life and death
Katikaneni, D. S., & Jin, L. (2018) · Human Immunology · doi:10.1016/j.humimm.2018.04.013 · Cited by 49
“The activation of NF-κB in T cells is associated with cell proliferation and differentiation [73].”
BackgroundGao, L., Dong, Y., Lin, R., Meng, Y., Wu, F., & Jia, L. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111177 · Cited by 53
Metadata
- Authors
- Oh, H., & Ghosh, S.
- Affiliations
- Department of Microbiology and Immunology Columbia University New York NY
- Columbia University (US)
- Corresponding author
- Ghosh, Sankar
- ORCID
- Ghosh, Sankar
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2013-02-13
- Volume
- 252
- Issue
- 1
- Pages
- 41-51
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC3576882
- OpenAlex
- W2070085523
- Cited by
- 408
- References
- 71
- Citations by year
- 2026: 16 · 2025: 36 · 2024: 43 · 2023: 46 · 2022: 43 · 2021: 39 · 2020: 28 · 2019: 25 · 2018: 27 · 2017: 26 · 2016: 26 · 2015: 24 · 2014: 21 · 2013: 7
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (R37-33443, R01-68977)
- National Institute of Allergy and Infectious Diseases (R01AI068977, R37AI033443)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- NF-κB signaling, CD4+ T cells, T helper cell differentiation, Th1 cells, Th2 cells, Th17 cells, Th9 cells, Th22 cells, T follicular helper cells, regulatory T cells, transcriptional regulation, cytokine and chemokine expression, adaptive immunity, inflammation
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Humans, Lymphocyte Activation, Transcription Factors, Transcription, Genetic, Signal Transduction, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Cytokines, NF-kappa B, Mice, Adaptive Immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
