The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses
Open accessAbstract
Summary: The immunogenicity of cancer cells is an emerging determinant of anti‐cancer immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based vaccines, immune‐checkpoint blockers, and adoptive T‐cell transfer, investigators are beginning to focus on the immunobiology of dying cancer cells and its relevance for the success of anticancer immunotherapies. It is currently accepted that cancer cells may die in response to anti‐cancer therapies through regulated cell death programs, which may either repress or increase their immunogenic potential. In particular, the induction of immunogenic cancer cell death ( ICD ), which is hallmarked by the emission of damage‐associated molecular patterns (DAMPs); molecules analogous to pathogen‐associated molecular patterns (PAMPs) acting as danger signals/alarmins, is of great relevance in cancer therapy. These ICD ‐associated danger signals favor immunomodulatory responses that lead to tumor‐associated antigens (TAAs)‐directed T‐cell immunity, which paves way for the removal of residual, treatment‐resistant cancer cells. It is also emerging that cancer cells succumbing to ICD can orchestrate “altered‐self mimicry” i.e. mimicry of pathogen defense responses, on the levels of nucleic acids and/or chemokines (resulting in type I interferon/ IFN responses or pathogen response‐like neutrophil activity). In this review, we exhaustively describe the main molecular, immunological, preclinical, and clinical aspects of immunosuppressive cell death or ICD (with respect to apoptosis, necrosis and necroptosis). We also provide an extensive historical background of these fields, with special attention to the self/non‐self and danger models, which have shaped the field of cell death immunology.
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Cites
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Cited by
Saxena, M., van der Burg, S. H., Melief, C. J. M., & Bhardwaj, N. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00346-0 · Cited by 1,581
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors
Galluzzi, L., Humeau, J., Buqué, A., Zitvogel, L., & Kroemer, G. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0413-z · Cited by 1,349
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Martinez, A. B., Chan, T. A., Coukos, G., Demaria, S., Deutsch, E., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000337 · Cited by 1,119
Self-citationEndoplasmic reticulum stress signalling-from basic mechanisms to clinical applications
Almanza, A., Carlesso, A., Chintha, C., Creedican, S., Doultsinos, D., Leuzzi, B., Luís, A., McCarthy, N., Montibeller, L., More, S., et al. (2019) · The FEBS Journal · doi:10.1111/febs.14608 · Cited by 1,034
Self-citation
Metadata
- Authors
- Garg, A. D., & Agostinis, P.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2017-10-13
- Volume
- 280
- Issue
- 1
- Pages
- 126-148
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2762577984
- Cited by
- 440
- References
- 54
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- green
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