Cited by 1,349Cancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesFerroptosis and cancer prognosis

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

Galluzzi, Lorenzo, Humeau, Juliette, Buqué, Aitziber, Zitvogel, Laurence, Kroemer, Guido·2020·Nature Reviews Clinical Oncology

Abstract

Conventional chemotherapeutics have been developed into clinically useful agents based on their ability to preferentially kill malignant cells, generally owing to their elevated proliferation rate. Nonetheless, the clinical activity of various chemotherapies is now known to involve the stimulation of anticancer immunity either by initiating the release of immunostimulatory molecules from dying cancer cells or by mediating off-target effects on immune cell populations. Understanding the precise immunological mechanisms that underlie the efficacy of chemotherapy has the potential not only to enable the identification of superior biomarkers of response but also to accelerate the development of synergistic combination regimens that enhance the clinical effectiveness of immune checkpoint inhibitors (ICIs) relative to their effectiveness as monotherapies. Indeed, accumulating evidence supports the clinical value of combining appropriately dosed chemotherapies with ICIs. In this Review, we discuss preclinical and clinical data on the immunostimulatory effects of conventional chemotherapeutics in the context of ICI-based immunotherapy.

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Crossref · 10.1038/s41571-020-0413-z

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281 of 281 references verified0 citation errors · 0 not checkable

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  • Immunogenic cell death is featured with upregulated DAMPs such as secretion of IFN-I, exposure of CRT on the cell membrane, leak of ATP, and release of HMGB1.

    “Immunogenic cell death is featured with some upregulated damage-associated molecular patterns (DAMPs) such as the secretion of IFN-I, the exposure of endoplasmic reticulum proteins especially calreticulin (CRT, an eat-me signal) on cell membrane, the leak of ATP (a find-me signal), and the release of high-mobility group box 1 (HMGB1) [35].”

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Authors
Galluzzi, L., Humeau, J., Buqué, A., Zitvogel, L., & Kroemer, G.
Affiliations
  • Université Paris Cité (FR)
  • Université Paris-Sud (FR)
  • Weill Cornell Medicine (US)
  • Karolinska University Hospital (SE)
Corresponding author
  • Galluzzi, Lorenzo
  • Kroemer, Guido
Venue
Nature Reviews Clinical Oncology
Published
2020-08-05
Volume
17
Issue
12
Pages
725-741
ISSN
  • 1759-4774 (ISSN-L)
  • 1759-4782
OpenAlex
W3047618013
Cited by
1,349
References
281
Citations by year
2026: 150 · 2025: 232 · 2024: 269 · 2023: 282 · 2022: 272 · 2021: 127 · 2020: 17
FWCI
18.73
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Agence Nationale de la Recherche (ANR-16-ECVD-0008)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords
chemotherapy, immune checkpoint inhibitors, immunostimulation, cancer immunotherapy, combination therapy, immunogenic cell death, synergy mechanism, treatment response biomarkers
MeSH terms
Antineoplastic Agents, Immunological, Immune Checkpoint Inhibitors, Humans, Immunity, Immunization, Immunotherapy, Neoplasms

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