Impact of Age-, Cancer- and Treatment-Driven Inflammation on T Cell Function and Immunotherapy

The Hallmarks of Aging

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Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

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The Immune Landscape of Cancer

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

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Neutrophil recruitment and function in health and inflammation

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The senescence-associated secretory phenotype: the dark side of tumor suppression

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IL‐6 in inflammation, immunity, and disease

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International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma

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Chronic inflammation in the etiology of disease across the life span

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Cellular senescence: when bad things happen to good cells

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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Prostaglandins and Inflammation

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Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

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An immunogenic personal neoantigen vaccine for patients with melanoma

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Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

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Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

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Signaling in innate immunity and inflammation

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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

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L1 drives IFN in senescent cells and promotes age-associated inflammation

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Safety and Antitumor Activity of Anti–PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer

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Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study

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CXCR3 in T cell function

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c-Jun overexpression in CAR T cells induces exhaustion resistance

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How the ageing microenvironment influences tumour progression

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Multiple Myeloma: Diagnosis and Treatment

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MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.

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Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination

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CD28− T cells: their role in the age-associated decline of immune function

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Advances in ovarian cancer therapy

Cortez, A. J., Tudrej, P., Kujawa, K. A., & Lisowska, K. M. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3501-8 · Cited by 625 · see citing works

Possible Role of Ovarian Epithelial Inflammation in Ovarian Cancer

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Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution

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A monoclonal gammopathy precedes multiple myeloma in most patients

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CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27− Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian Cancer

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Sex and Gender Differences in the Outcomes of Vaccination over the Life Course

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Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

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Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

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Tumor-Infiltrating Lymphocytes Expressing the Tissue Resident Memory Marker CD103 Are Associated with Increased Survival in High-Grade Serous Ovarian Cancer

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Resolution of chronic inflammatory disease: universal and tissue-specific concepts

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Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

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Distinctions Between CD8+ and CD4+ T-Cell Regenerative Pathways Result in Prolonged T-Cell Subset Imbalance After Intensive Chemotherapy

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Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

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p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

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Interleukin-6 as a Therapeutic Target in Human Ovarian Cancer

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The family of the interleukin‐1 receptors

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Aging, obesity, and inflammatory age-related diseases

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Advanced Age Is an Independent Risk Factor for Severe Infections and Mortality in Patients Given Anti–Tumor Necrosis Factor Therapy for Inflammatory Bowel Disease

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Elevated IL-17 produced by Th17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma

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Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

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Molecular pathogenesis of multiple myeloma and its premalignant precursor

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Phenotypic transitions of macrophages orchestrate tissue repair.

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The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

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Feasibility and efficacy of CD19-targeted CAR T cells with concurrent ibrutinib for CLL after ibrutinib failure

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Constraints on CD4 Recovery Postchemotherapy in Adults: Thymic Insufficiency and Apoptotic Decline of Expanded Peripheral CD4 Cells

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Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection

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Ovarian cancer: Age contrasts in incidence, histology, disease stage at diagnosis, and mortality

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Recent trends in multiple myeloma incidence and survival by age, race, and ethnicity in the United States

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IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis

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A sestrin-dependent Erk–Jnk–p38 MAPK activation complex inhibits immunity during aging

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Down-Regulation of CD28 Expression by TNF-α

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Interferon β decreases T cell activation and interferon γ production in multiple sclerosis

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Complete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: analysis of 1175 patients

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Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

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PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients

Naing, A., Infante, J. R., Papadopoulos, K. P., Chan, I. H., Shen, C., Ratti, N. P., Rojo, B., Autio, K. A., Wong, D. J. L., Patel, M. R., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.10.007 · Cited by 255 · see citing works

Intracellular regulation of TNF activity in health and disease

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Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium

Trabert, B., Ness, R. B., Lo-Ciganic, W.-H., Murphy, M. A., Goode, E. L., Poole, E. M., Brinton, L. A., Webb, P. M., Nagle, C. M., Jordan, S. J., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt431 · Cited by 243 · see citing works

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

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A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

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Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes

Moro‐García, M. A., Mayo, J. C., Sainz, R. M., & Alonso‐Arias, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00339 · Cited by 232 · see citing works

Cutting Edge: Involvement of the Type I IFN Production and Signaling Pathway in Lipopolysaccharide-Induced IL-10 Production

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Reduction in the Developmental Potential of Intrathymic T Cell Progenitors with Age

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Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma

Dhodapkar, K. M., Barbuto, S., Matthews, P., Kukreja, A., Mazumder, A., Vesole, D. H., Jagannath, S., & Dhodapkar, M. V. (2008) · Blood · doi:10.1182/blood-2008-03-143222 · Cited by 215 · see citing works

A novel role of IL-17–producing lymphocytes in mediating lytic bone disease in multiple myeloma

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Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β

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Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade

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Tumor Necrosis Factor α and Regulatory T Cells in Oncoimmunology

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Molecular mechanisms of inflammasome signaling

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Infection risk associated with anti-TNF-α agents: a review

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CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

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