NLRP3 inflammasome activation in inflammaging

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Alzheimer’s disease

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Inflammasomes in health and disease

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The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

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Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

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The intersection between aging and cardiovascular disease

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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

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Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

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Genomic instability in laminopathy-based premature aging

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Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population

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Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

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Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

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Determinants of Muscle and Bone Aging

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Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.

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β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares

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Inflammation and neurodegenerative diseases

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Uric acid promotes an acute inflammatory response to sterile cell death in mice

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Metabolic regulation of <scp>NLRP</scp> 3

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Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System

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Immunobiography and the heterogeneity of immune responses in the elderly: A focus on inflammaging and trained immunity

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CD200 Ligand–Receptor Interaction Modulates Microglial Activation<i>In Vivo</i>and<i>In Vitro</i>: A Role for IL-4

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DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation

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Inflammasome Priming in Sterile Inflammatory Disease

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Dysregulation of human Toll-like receptor function in aging

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Fractalkine‐induced activation of the phosphatidylinositol‐3 kinase pathway attentuates microglial activation <i>in vivo</i> and <i>in vitro</i>

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Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances

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Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

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Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome

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Increased adipose tissue expression of IL-18R and its ligand IL-18 associates with inflammation and insulin resistance in obesity

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Evaluation of inflammation and follicle depletion during ovarian ageing in mice

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Similarities and interplay between senescent cells and macrophages

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Pro-Aging Effects of Xanthine Oxidoreductase Products

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Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages

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