The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
Abstract
Summary: Cross‐presentation involves the uptake and processing of exogenous antigens within the major histocompatibility complex (MHC) class I pathway. This process is primarily performed by dendritic cells (DCs), which are not a single cell type but may be divided into several distinct subsets. Those expressing CD8α together with CD205, found primarily in the T‐cell areas of the spleen and lymph nodes, are the major subset responsible for cross‐presenting cellular antigens. This ability is likely to be important for the generation of cytotoxic T‐cell immunity to a variety of antigens, particularly those associated with viral infection, tumorigenesis, and DNA vaccination. At present, it is unclear whether the CD8α‐expressing DC subset captures antigen directly from target cells or obtains it indirectly from intermediary DCs that traffic from peripheral sites. In this review, we examine the molecular basis for cross‐presentation, discuss the role of DC subsets, and examine the contribution of this process to immunity, with some emphasis on DNA vaccination.
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Cites
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“Several other cell types have been reported to cross-present, including B cells (15), endothelial cells (16, 17), and particularly macrophages (18–22), the latter of which have in some cases been compared to DCs (22).”
BackgroundResultPhagocytic processing of bacterial antigens for class I MHC presentation to T cells
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“These include soluble proteins (12, 23), immune complexes (13, 24), intracellular bacteria (25), parasites (26), and, most importantly, cellular antigens (22, 27–34).”
BackgroundContribution of CpG motifs to the immunogenicity of DNA vaccines
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Cited by
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Type I interferon is selectively required by dendritic cells for immune rejection of tumors
Diamond, M. S., Kinder, M., Matsushita, H., Mashayekhi, M., Dunn, G. P., Archambault, J. M., Lee, H., Arthur, C. D., White, J. M., Kalinke, U., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101158 · Cited by 1,081
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells
Luber, C. A., Cox, J., Lauterbach, H., Fancke, B., Selbach, M., Tschopp, J., Akira, S., Wiegand, M., Hochrein, H., O'Keeffe, M., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.013 · Cited by 576
Materials engineering for immunomodulation
Hubbell, J. A., Thomas, S. N., & Swartz, M. A. (2009) · Nature · doi:10.1038/nature08604 · Cited by 561
Phagocytosis and antigen presentation in dendritic cells
Savina, A., & Amigorena, S. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00552.x · Cited by 561
Metadata
- Authors
- Heath, W. R., Belz, G. T., Behrens, G. M. N., Smith, C. M., Forehan, S. P., Parish, I. A., Davey, G. M., Wilson, N. S., Carbone, F. R., & Villadangos, J. A.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2004-05-05
- Volume
- 199
- Issue
- 1
- Pages
- 9-26
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1997276741
- Cited by
- 735
- References
- 5
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heath, W. R., Belz, G. T., Behrens, G. M. N., Smith, C. M., Forehan, S. P., Parish, I. A., Davey, G. M., Wilson, N. S., Carbone, F. R., & Villadangos, J. A. (2004). Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunological Reviews. https://doi.org/10.1111/j.0105-2896.2004.00142.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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