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Exercise, Lipids, and Lipoproteins in Older Adults: A Meta‐Analysis
Open accessAbstract
The authors used the meta‐analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults 50 years of age and older. Twenty‐eight outcomes representing 1427 subjects (806 exercise, 621 control) were available for pooling. Random‐effects modeling yielded statistically significant improvements of 1.1%, 5.6%, 2.5%, and 7.1%, respectively, for total cholesterol (mean ± SEM in mg/dL, −3.3±1.7; 95% confidence interval [CI], −6.5 to −0.02; p=0.05), high‐density lipoprotein cholesterol (2.5±1.0; 95% CI, 0.7–4.4; p=0.01), low‐density lipoprotein cholesterol (−3.9±1.9; 95% CI, −7.7 to −0.08; p=0.05), ratio of total cholesterol to high‐density lipoprotein cholesterol (−0.8±0.2; 95% CI, −1.2 to −0.4; p<0.001), but not triglycerides (−7.0±3.6; 95% CI, −14.0 to 0.1; p=0.06). After conducting sensitivity analyses, only the improvements in high‐density lipoprotein cholesterol and the ratio of total cholesterol to high‐density lipoprotein cholesterol remained statistically significant (p<0.05 for both). It was concluded that aerobic exercise increases high‐density lipoprotein cholesterol and decreases the ratio of total cholesterol to high‐density lipoprotein cholesterol in older adults.
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“Six reported a significant increase in HDL-C levels, which was the most frequently observed effect of exercise on serum lipids577, 607–613).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [609]
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“Aerobic exercise is effective in improving lipid metabolism607–615).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [609]
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Metadata
- Authors
- Kelley, G. A., Kelley, K. S., & Tran, Z. V.
- Affiliations
- West Virginia University (US)
- Venue
- Preventive Cardiology
- Publisher
- Wiley
- Published
- 2005-09
- Volume
- 8
- Issue
- 4
- Pages
- 206-214
- ISSN
- 1520-037X (ISSN-L)
- 1751-7141
- PMC
- PMC2447857
- OpenAlex
- W2009903068
- Cited by
- 118
- References
- 50
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 13 · 2012: 6
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Preventive Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL069802)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- aerobic exercise, older adults, lipoproteins, cholesterol, HDL cholesterol, LDL cholesterol, TC/HDL-C ratio, triglycerides, lipid profile, cardiovascular risk
- MeSH terms
- Female, Humans, Lipids, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Exercise
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