Cited by 118Cardiovascular and exercise physiologyLipoproteins and Cardiovascular HealthPhysical Activity and Health

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Exercise, Lipids, and Lipoproteins in Older Adults: A Meta‐Analysis

Open access

Kelley, George A., Kelley, Kristi S., Tran, Zung V.·2005·Preventive Cardiology

DOI 10.1111/j.0197-3118.2005.03769.xPMC PMC2447857

Open this paper in CoChat — free account

Abstract

The authors used the meta‐analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults 50 years of age and older. Twenty‐eight outcomes representing 1427 subjects (806 exercise, 621 control) were available for pooling. Random‐effects modeling yielded statistically significant improvements of 1.1%, 5.6%, 2.5%, and 7.1%, respectively, for total cholesterol (mean ± SEM in mg/dL, −3.3±1.7; 95% confidence interval [CI], −6.5 to −0.02; p=0.05), high‐density lipoprotein cholesterol (2.5±1.0; 95% CI, 0.7–4.4; p=0.01), low‐density lipoprotein cholesterol (−3.9±1.9; 95% CI, −7.7 to −0.08; p=0.05), ratio of total cholesterol to high‐density lipoprotein cholesterol (−0.8±0.2; 95% CI, −1.2 to −0.4; p<0.001), but not triglycerides (−7.0±3.6; 95% CI, −14.0 to 0.1; p=0.06). After conducting sensitivity analyses, only the improvements in high‐density lipoprotein cholesterol and the ratio of total cholesterol to high‐density lipoprotein cholesterol remained statistically significant (p<0.05 for both). It was concluded that aerobic exercise increases high‐density lipoprotein cholesterol and decreases the ratio of total cholesterol to high‐density lipoprotein cholesterol in older adults.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.0197-3118.2005.03769.x

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,772
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
Aspirin plus Clopidogrel as Secondary Prevention after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609
Untitled work
(2000) · Cited by 9,198

Show all 50 references

Research works printed but not linked: 2

Ruoti RG, 1989, The Effects of Calisthenic Water Exercise on Selected Work, Physiologic, and Blood Parameters of Older Adults
10.1001/jama.1985.03360070057023 · DOI

Sorted by citations

2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Eckel, R. H., Jakicic, J. M., Ard, J. D., de Jesus, J. M., Miller, N. H., Hubbard, V. S., Lee, I.-M., Lichtenstein, A. H., Loria, C. M., Millen, B. E., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437740.48606.d1 · Cited by 2,261
Exercise Standards for Testing and Training: A Scientific Statement From the American Heart Association
Fletcher, G. F., Ades, P. A., Kligfield, P., Arena, R., Balady, G. J., Bittner, V. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829b5b44 · Cited by 2,235
The Metabolic Syndrome
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162
2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk
Eckel, R. H., Jakicic, J. M., Ard, J. D., de Jesus, J. M., Houston Miller, N., Hubbard, V. S., Lee, I.-M., Lichtenstein, A. H., Loria, C. M., Millen, B. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.003 · Cited by 1,160
Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813
Health benefits of physical activity in older patients: a review
Vogel, T., Bréchat, P.-H., Leprêtre, P., Kaltenbach, G., Berthel, M., & Lonsdorfer, J. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01957.x · Cited by 575
The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia
Fruchart, J.-C., Sacks, F., Hermans, M. P., Assmann, G., Brown, W. V., Ceska, R., Chapman, M. J., Dodson, P. M., Fioretto, P., Ginsberg, H. N., et al. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.10.002 · Cited by 463
Physical activity during leisure time and primary prevention of coronary heart disease: an updated meta-analysis of cohort studies
Sofi, F., Capalbo, A., Cesari, F., Abbate, R., & Gensini, G. F. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282f232ac · Cited by 416
Biomarkers shared by frailty and sarcopenia in older adults: A systematic review and meta-analysis
Picca, A., Coelho‐Júnior, H. J., Calvani, R., Marzetti, E., & Vetrano, D. L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101530 · Cited by 383
Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 345
Exercise Dose in Clinical Practice
Wasfy, M. M., & Baggish, A. L. (2016) · Circulation · doi:10.1161/circulationaha.116.018093 · Cited by 292
The Effect of Exercise on the Cardiovascular Risk Factors Constituting the Metabolic Syndrome: A Meta-Analysis of Controlled Trials
Pattyn, N., Cornelissen, V. A., Eshghi, S. R. T., & Vanhees, L. (2013) · Sports Medicine · doi:10.1007/s40279-012-0003-z · Cited by 266
“[25] that a decrease of 1% in HDL-C would be associated with an increase in the risk for coronary heart disease of 2–3%.”
Background
The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patients
Fruchart, J.-C., Sacks, F. M., Hermans, M. P., Assmann, G., Brown, W. V., Ceska, R., Chapman, M. J., Dodson, P. M., Fioretto, P., Ginsberg, H. N., et al. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.046 · Cited by 260
Responses of blood lipids to aerobic, resistance, and combined aerobic with resistance exercise training: a systematic review of current evidence.
Tambalis, K., Panagiotakos, D. B., Kavouras, S. A., & Sidossis, L. S. (2009) · Angiology · doi:10.1177/0003319708324927 · Cited by 224
Aerobic, resistance or combined training: a systematic review and meta-analysis of exercise to reduce cardiovascular risk in adults with metabolic syndrome
Wewege, M. A., Thom, J. M., Rye, K.-A., & Parmenter, B. J. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.05.002 · Cited by 210
Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise
Brook, M. S., Wilkinson, D. J., Phillips, B. E., Pérez‐Schindler, J., Philp, A., Smith, K., & Atherton, P. J. (2015) · Acta Physiologica · doi:10.1111/apha.12532 · Cited by 214
“…et al. 2011), and this may be associated with additional substantial health benefits, that is increases in strength, resting metabolic rate (Lemmer et al. 2001), glucose tolerance (Craig et al. 1989), reduced blood pressure (Hagberg et al. 1989) and improved lipid profile (Kelley et al. 2005).”
Background
Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches
Nikolić, D., Katsiki, N., Montalto, G., Isenović, E. R., Mikhailidis, D. P., & Rizzo, M. (2013) · Nutrients · doi:10.3390/nu5030928 · Cited by 162
“Several recent meta-analyses [118–120] have also reported beneficial effects of exercise on lipids and lipoproteins in patients with MetS, in accordance with the results of many studies that have reported”
Result
150 minutes of vigorous physical activity per week predicts survival and successful ageing: a population-based 11-year longitudinal study of 12 201 older Australian men
Almeida, O. P., Khan, K., Hankey, G. J., Yeap, B. B., Golledge, J., & Flicker, L. A. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092814 · Cited by 149
Leisure time but not occupational physical activity significantly affects cardiovascular risk factors in an adult population
Sofi, F., Capalbo, A., Marcucci, R., Gori, A. M., Fedi, S., Macchi, C., Casini, A., Surrenti, C., Abbate, R., & Gensini, G. F. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01884.x · Cited by 110
Evidence of Lifestyle Modification in the Management of Hypercholesterolemia
Mannu, G., Zaman, M., Gupta, A., Rehman, H. U., & Myint, P. K. (2013) · Current Cardiology Reviews · doi:10.2174/157340313805076313 · Cited by 121
Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: A comparison of older with young men
Karaouzene, N., Merzouk, H., Aribi, M., Merzouk, S. A., Yahia Berrouiguet, A., Tessier, C., & Narce, M. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.02.007 · Cited by 106
“It has been shown that older adults had also abnormal serum lipids and lipoproteins [14].”
Background
The Role of Healthy Lifestyle in the Primordial Prevention of Cardiovascular Disease
Claas, S. A., & Arnett, D. K. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0728-7 · Cited by 86
An Updated Systematic Review on the Effects of Aerobic Exercise on Human Blood Lipid Profile
Doewes, R. I., Gharibian, G., zadeh, F. A., Zaman, B. A., vahdat, S., & Akhavan-Sigari, R. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101108 · Cited by 85
Exercise-Induced Changes in Cardiovascular Function after Stroke: A Randomized Controlled Trial
Tang, A., Eng, J. J., Krassioukov, A. V., Madden, K. M., Mohammadi, A., Tsang, M. Y. C., & Tsang, T. S. M. (2014) · International Journal of Stroke · doi:10.1111/ijs.12156 · Cited by 69
Physical activity or fitness and the metabolic syndrome
Ford, E. S., & Li, C. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.6.897 · Cited by 66
Detraining-induced alterations in adipokines and cardiometabolic risk factors after nonlinear periodized resistance and aerobic interval training in obese men
Nikseresht, M., Hafezi Ahmadi, M. R., & Hedayati, M. (2016) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2015-0693 · Cited by 61
“A metaanalysis showed that a 1% decrease in HDL-C would be associated with a 2%–3% increase in the risk of coronary disease (Kelley et al. 2005).”
Background
Leitlinie körperliche Aktivität zur Sekundärprävention und Therapie kardiovaskulärer Erkrankungen
Bjarnason‐Wehrens, B., Schulz, O., Gielen, S., Halle, M., Dürsch, M., Hambrecht, R., Lowis, H., Kindermann, W., Schulze, R., & Rauch, B. (2009) · Clinical Research in Cardiology Supplements · doi:10.1007/s11789-009-0078-8 · Cited by 58
Exercise training ameliorates the effects of rosiglitazone on traditional and novel cardiovascular risk factors in patients with type 2 diabetes mellitus
Kadoglou, N. P. E., Iliadis, F. S., Sailer, N., Athanasiadou, Z. S., Vitta, I., Kapelouzou, A., Karayannacos, P. E., Liapis, C. D., Alevizos, M., Angelopoulou, N., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.09.002 · Cited by 55
“Furthermore, exercise training induces favorable changes in lipid profile and restricts both visceral and total body adiposity, the main resources of insulin resistance [12-17].”
Background
Effects of exogenous vitamins A, C, and E and NADH supplementation on proliferation, cytokines release, and cell redox status of lymphocytes from healthy aged subjects
Bouamama, S., Merzouk, H., Medjdoub, A., Merzouk, A. S., & Merzouk, S. A. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0201 · Cited by 48
Metabolic syndrome and polycystic ovary syndrome: an intriguing overlapping
Caserta, D., Adducchio, G., Picchia, S., Ralli, E., Matteucci, E., & Moscarini, M. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.887673 · Cited by 43
“Niacin is most potent available drug to raise HDL-C, to reduce triglycerides, LDL-C, thus it is very useful to treat metabolic dyslipidemia.”
Influential
Minor effects of green tea catechin supplementation on cardiovascular risk markers in active older people: A randomized controlled trial
Miyazaki, R., Kotani, K., Ayabe, M., Tsuzaki, K., Shimada, J., Sakane, N., Takase, H., Ichikawa, H., Yonei, Y., & Ishii, K. (2012) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2012.00952.x · Cited by 39
Effect of 5 years of exercise training on the cardiovascular risk profile of older adults: the Generation 100 randomized trial
Letnes, J. M., Berglund, I., Johnson, K. E., Dalen, H., Nes, B. M., Lydersen, S., Viken, H., Hassel, E., Steinshamn, S., Vesterbekkmo, E. K., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab721 · Cited by 40
Effects of Aerobic Exercise Alone on Lipids in Healthy East Asians: A Systematic Review and Meta-Analysis
Igarashi, Y., Akazawa, N., & Maeda, S. (2019) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.45864 · Cited by 38
Effect of Exercise Intervention on Changes in Free Fatty Acid Levels and Metabolic Risk Factors in Stroke Patients
Kim, D.-Y., Jung, S., & Seo, B.-D. (2014) · Journal of Physical Therapy Science · doi:10.1589/jpts.26.275 · Cited by 32
Which Physical Exercise Interventions Increase HDL-Cholesterol Levels? A Systematic Review of Meta-analyses of Randomized Controlled Trials
Palazón‐Bru, A., Hernández-Lozano, D., & Gil-Guillén, V. F. (2020) · Sports Medicine · doi:10.1007/s40279-020-01364-y · Cited by 30
Response of Lipids and Lipoproteins to Regular Aquatic Endurance Exercise: A Meta-Analysis of Randomized Controlled Trials
Igarashi, Y., & Nogami, Y. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.42937 · Cited by 31
2013 American Heart Association/American College of Cardiology Guideline on Lifestyle Management to Reduce Cardiovascular Risk: Practice Opportunities for Registered Dietitian Nutritionists
Millen, B. E., Wolongevicz, D. M., Jesus, J. M. D., Nonas, C., & Lichtenstein, A. H. (2014) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2014.07.037 · Cited by 28
The role of exercise in mitigating subcortical ischemic vascular cognitive impairment
Dao, E. A., Hsiung, G. R., & Liu-Ambrose, T. Y. L. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14153 · Cited by 30
The Yale Fitness Intervention Trial in female cancer survivors: Cardiovascular and physiological outcomes
Knobf, M. T., Jeon, S., Smith, B., Harris, L., Thompson, S., Stacy, M. R., Insogna, K., & Sinusas, A. J. (2017) · Heart & Lung · doi:10.1016/j.hrtlng.2017.06.001 · Cited by 26
Examining the Dose–Response Relationship between Physical Activity and Health Outcomes
Wasfy, M. M., & Lee, I.-M. M. (2022) · NEJM Evidence · doi:10.1056/evidra2200190 · Cited by 29
Effects of interval training on quality of life and cardiometabolic risk markers in older adults: a randomized controlled trial
Ballin, M., Lundberg, E., Sörlén, N., Nordström, P., Hult, A., & Nordström, A. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s213133 · Cited by 27
Efeito da dieta e do ciclismo indoor sobre a composição corporal e nível sérico lipídico
do Valle, V. S., de Mello, D. B., Fortes, M. D. S. R., Dantas, E. H. M., & de Mattos, M. A. (2010) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2010005000080 · Cited by 25
Effects of Exercise Intervention on Vascular Risk Factors in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial
Uemura, K., Doi, T., Shimada, H., Makizako, H., Yoshida, D., Tsutsumimoto, K., Anan, Y., & Suzuki, T. (2012) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000343486 · Cited by 23
The Effect of Regular Aerobic Exercise on Reverse Cholesterol Transport A1 and Apo Lipoprotein A-I Gene Expression in Inactive Women
Tofighi, A., Rahmani, F., Jamali Qarakhanlou, B., & Babaei, S. (2015) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.17(4)2015.26321 · Cited by 22
Impact of a 12-Week Randomized Exercise Training Program on Lipid Profile in Severely Obese Patients Following Bariatric Surgery
Tardif, I., Auclair, A., Piché, M., Biertho, L. D., Marceau, S., Hould, F., Biron, S., Lebel, S., Lescelleur, O., & Poirier, P. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04647-5 · Cited by 22
Exercise training increases skeletal muscle strength independent of hypertrophy in older adults aged 75 years and older
Lee, H., Kim, I., Sung, C., Jeon, T., Cho, K., Ha, Y., Park, K., Yoo, J., Kang, G. H., Kim, S. J., et al. (2019) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13597 · Cited by 22
Influence of Moderate, Daily Physical Activity On Body Composition and Blood Lipid Profile in Swedish Adults
Pagels, P., Raustorp, A., Archer, T., Lidman, U., & Alricsson, M. (2012) · Journal of Physical Activity and Health · doi:10.1123/jpah.9.6.867 · Cited by 20
Lifetime Risk for Developing Dyslipidemia: The Framingham Offspring Study
Cobain, M. R., Pencina, M. J., D’Agostino, R. B., & Vasan, R. S. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.12.015 · Cited by 21
Salutary effects of high-intensity interval training in persons with elevated cardiovascular risk
Fleg, J. L. (2016) · F1000Research · doi:10.12688/f1000research.8778.1 · Cited by 19
Changes in cardiovascular-health blood biomarkers in response to exercise intervention among older adults with cognitive frailty: A scoping review
Ibrahim, A., Ludin, A. F. M., Singh, D. K. A., Rajab, N. F., & Shahar, S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1077078 · Cited by 18
“Exercise, especially aerobic exercise, has been reported effective in improving the lipid profile among healthy adults and even Alzheimer population (Kelley et al., 2005; Jensen et al., 2020).”
Background
Effects of Exercise Combined with a Healthy Diet or Calanus finmarchicus Oil Supplementation on Body Composition and Metabolic Markers—A Pilot Study
Wasserfurth, P., Nebl, J., Schuchardt, J. P., Müller, M., Boßlau, T. K., Krüger, K., & Hahn, A. (2020) · Nutrients · doi:10.3390/nu12072139 · Cited by 20
The Long-term Effect of Different Exercise Intensities on High-Density Lipoprotein Cholesterol in Older Men and Women Using the Per Protocol Approach: The Generation 100 Study
Berglund, I., Vesterbekkmo, E. K., Retterstøl, K., Anderssen, S. A., Singh, M. A. F., Helge, J. W., Lydersen, S., Wisløff, U., & Stensvold, D. (2021) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2021.07.002 · Cited by 17
Impact of high-intensity interval training on cardio-metabolic health outcomes and mitochondrial function in older adults: a review
Mahatme, S., Vaishali, K., Kumar, N., Rao, V., Kovela, R. K., & Sinha, M. K. (2022) · Medicine and Pharmacy Reports · doi:10.15386/mpr-2201 · Cited by 22
“The underlying mechanism is associated with a sequence of changes occurring in the skeletal muscle with aging [91].”
Background
Moderate Aerobic Training Decreases Blood Pressure but No Other Cardiovascular Risk Factors in Hypertensive Overweight/Obese Elderly Patients
Ramos, R. M., Coelho‐Júnior, H. J., Prado, R. C. R., da Silva, R. S., Asano, R. Y., Prestes, J., Medeiros, A. I. A., Rodrigues, B., & Assumpção, C. D. O. (2018) · Gerontology and Geriatric Medicine · doi:10.1177/2333721418808645 · Cited by 17
Exercise-induced inflammatory and metabolic adaptations in ageing: A meta-analytic compendium
Sheldon, R., Gan, A., Tasong, J., Yap, A., Ahmad, M., Júnior, P. R. H., Viswanathan, K., Setti, N. S. M., Jarman, O., Hoque-Uddin, M. S., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102974 · Cited by 16
Dyslipidaemia in the elderly: to treat or not to treat?
Katsiki, N., Kolovou, G. D., Pérez‐Martínez, P., & Mikhailidis, D. P. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1425138 · Cited by 14
“Aerobic exercise was also shown to significantly improve TC, LDL-C, HDL-C levels, and TC to HDL-C ratio (but not TG concentrations) in people with a mean age of 63 years in a previous meta-analysis [105].”
Biomarkers of cardiovascular disease risk in 40–65-year-old men performing recommended levels of physical activity, compared with sedentary men
Perkins, G., Owen, A., Kearney, E. M., & Swaine, I. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2007.044420 · Cited by 14
Long-term detraining increases the risk of metabolic syndrome in Japanese men.
Mitsuhashi, T., Yamada, C., Iida, A., Hiratsuka, N., Inabe, F., Araida, N., Moriyama, K., Sasamori, H., Sasamori, N., Miyachi, M., et al. (2011) · PubMed · Cited by 12
Physical Exercise May Increase Plasma Concentration of High-Density Lipoprotein-Cholesterol in Patients With Alzheimer’s Disease
Jensen, C. S., Musaeus, C. S., Frikke‐Schmidt, R., Andersen, B. B., Beyer, N., Gottrup, H., Høgh, P., Vestergaard, K., Wermuth, L., Frederiksen, K. S., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00532 · Cited by 11
“Among non-pharmacological interventions, exercise has previously been proven beneficial and shown to reduce LDL and increase HDL across all ages in cognitively normal individuals (Kelley et al., 2005).”
Background
Associations Between the Physical Activity Vital Sign and Cardiometabolic Risk Factors in High-Risk Youth and Adolescents
Nelson, V. R., Masocol, R. V., & Asif, I. M. (2019) · Sports Health A Multidisciplinary Approach · doi:10.1177/1941738119884083 · Cited by 13
“6% of American adolescents are insufficiently active.(9) In this study, only 41.”
Background
Effects of a multicomponent training followed by a detraining period on metabolic syndrome profile of older adults
Subías-Perié, J., Navarrete‐Villanueva, D., Fernández‐García, Á. I., Moradell, A., Lozano‐Berges, G., Gesteiro, E., Pérez‐Gómez, J., Ara, I., Gómez‐Cabello, A., Vicente‐Rodríguez, G., et al. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112363 · Cited by 14
“While some studies have reported that aerobic exercise can increase HDL-C levels (Kelley et al., 2005; Pattyn et al., 2013; Wewege et al., 2018), others, including Ostman et al. (2017), have found no significant effects.”
Background
Cardiovascular risk moderates the effect of aerobic exercise on executive functions in older adults with subcortical ischemic vascular cognitive impairment
Barha, C. K., Dao, E. A., Marcotte, L., Hsiung, G. R., Tam, R. C., & Liu-Ambrose, T. Y. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-99249-1 · Cited by 11
Dyslipidaemia among Nigerian oil workers with type 2 diabetes mellitus.
Edo, A., & Adediran, O. S. (2011) · PubMed · Cited by 10
Dyslipidemia Management for Elderly People with Metabolic Syndrome: A Mini-Review
Chen, C., Lee, C., Chien, S., Su, M., Lin, S.-I., Cheng, C.-W., Hung, T., & Yeh, H. (2017) · International journal of gerontology · doi:10.1016/j.ijge.2017.07.001 · Cited by 10
Association Between a Physical Activity Vital Sign and Cardiometabolic Disease in High-Risk Patients
Nelson, V. R., Masocol, R. V., Ewing, J. A., Johnston, S., Hale, A. L., Wiederman, M., & Asif, I. M. (2018) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0000000000000588 · Cited by 8
“Population-based physical activity interventions have demonstrated reductions in cardiovascular disease risk and cardiometabolic risk factors including blood pressure (BP)(12) and cholesterol.(13) Recently the role of an exercise or physical activity vital sign (PAVS) has been championed as an intervention strategy fo…”
Background
The boiling‐point relations of cadmium and zinc at elevated pressures
Baker, E. H. (1966) · Journal of Applied Chemistry · doi:10.1002/jctb.5010161102 · Cited by 7
Successful physical exercise-induced weight loss is modulated by habitual sleep duration in the elderly: results of a pilot study
Goerke, M., Sobieray, U., Becke, A., Düzel, E., Cohrs, S., & Müller, N. G. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1460-y · Cited by 7
Practice Guidelines Report of the American College of Cardiology/American Heart Association Task Force on 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A
Yanovski, Z., Sacks, F. M., Smith, S. C., Svetkey, L. P., Wadden, T. A., Lee, I.-M. M., Lichtenstein, A. H., Loria, C. M., Millen, B. E., Eckel, H., et al. (2014) · Cited by 6
EFEITO DO EXERCÍCIO SOBRE OS NÍVEIS DE HDL-C: UMA REVISÃO SISTEMÁTICA DE METANÁLISES
Fraga, A. S., Ladeia, A. M. T., de Sá, C. K. C., & Tenório, M. C. C. (2017) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-869220172306163603 · Cited by 6
Effects of Elastic Band and Aerobic Exercise on Fitness, Blood Lipids, and Vascular Inflammatory Markers in Elderly Women
Kim, K., & Cho, J.-H. (2013) · The Official Journal of the Korean Academy of Kinesiology · doi:10.15758/jkak.2013.15.2.105 · Cited by 6
Sex differences in total cholesterol of Vietnamese adults
Nga, T. T. T., Blizzard, C. L., Luong, K. N., Truong, N. L. V., Bao, T. Q., Otáhal, P., Nelson, M. R., Magnussen, C. G., Bui, T. V., Srikanth, V. K., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256589 · Cited by 5
“Sociodemographic characteristics and lifestyle factors may have an effect on lipid profiles [35, 36], and associations of these factors with TC have been observed in some studies [37, 38].”
Background
Effects and moderators of exercise medicine on cardiometabolic outcomes in men with prostate cancer previously or currently undergoing androgen deprivation therapy: An individual patient data meta-analysis
López, P., Newton, R. U., Taaffe, D. R., Winters‐Stone, K. M., Buffart, L. M., & Galvao, D. A. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.103995 · Cited by 5
Morning physical activity may be more beneficial for blood lipids than afternoon physical activity in older adults: a cross-sectional study
Kim, H., Kimura, Y., Takahashi, M., Nakaoka, T., Yamada, Y., Ono, R., & Shibata, S. (2024) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05526-y · Cited by 7
“Many epidemiological studies and meta-analyses demonstrate the effect of physical activity on CVDs and mortality across all age groups and demographics (Kelley et al. 2005; Koba et al. 2011).”
Background
Guidelines of the American College of Cardiology/American Heart Association Task Force on Practice 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report
LICHTENSTEIN, H., Loria, C. M., Millen, B. E., Miller, N. H., Nonas, C., Eckel, R. H., Jakicic, J. M., Ard, J. D., Hubbard, S. M., Jesus, J. M. D., et al. (2013) · Cited by 4
The effects of long-term aerobic and resistance combined exercise training on cardiovascular risk factors and oxidative stress in stroke patients
shinyuna, & Kim, H.-J. (2010) · Exercise Science · doi:10.15857/ksep.2010.19.3.231 · Cited by 4
EFFECTS OF EXERCISE TYPE AND INTENSITY ON VISFATIN AND THE METABOLIC SYNDROME IN OBESITY
Lee, J.-K. (2021) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-8692202127022020_0088 · Cited by 4
Evidence-based practice for enteral feedings: aspiration prevention strategies, bedside detection, and practice change.
Fellows, L., Miller, E. H., Frederickson, M., Bly, B., & Felt, P. (2000) · PubMed · Cited by 4
Clinical inquiries. Which lifestyle interventions effectively lower LDL cholesterol?
Powers, E., Saultz, J. W., Hamilton, A., & Lo, V. (2007) · PubMed · Cited by 4
Epidemiology of Atherosclerotic Cardiovascular Disease
Townsend, N. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.99735-7 · Cited by 5
BENEFITS OF AEROBIC EXERCISE TRAINING WITH RECOMMENDATIONS FOR HEALTHY AGING
Lazzer, S., Rejc, E., & del Torto, A. (2018) · Annales Kinesiologiae · doi:10.35469/ak.2017.135 · Cited by 3
Physical Activity in the Prevention of Heart Failure
Intwala, S., & Balady, G. J. (2015) · Circulation · doi:10.1161/circulationaha.115.018831 · Cited by 3
“The biological link between exercise and coronary heart disease protection has been attributed to improved antioxidative protection, changes in mitochondrial metabolism, favorable lipid changes (increase high-density lipoprotein, decrease low-density lipoprotein), and control of known atherosclerotic risk factors.(14,…”
Background
Cardiovascular health benefits of physical activity: aerobic, muscle-strengthening, and combined exercise modalities
Zhou, T., Su, S., Yuan, C., Jiang, D., Qiu, Y., Xiao, J., Lu, X., Gu, D., & Liu, F. (2026) · Medicine Plus · doi:10.1016/j.medp.2026.100137 · Cited by 2
Effect of green tea on the cardiovascular system
Maternia, J., Miszczyk, K., Maj, P., Sergiel, N., Kania, A., Gonet, M., Włodarczyk-Cybulska, K., Mozer, P., Lazar, M., & Serwik-Trandasir, A. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.46.01.014 · Cited by 2
“Mogą również przyczynić się do poprawy profilu lipidowego, regulując syntezę tłuszczów i obniżając absorpcję lipidów w jelicie [22].”
Adherence to aerobic training combined with high protein intake is associated with low blood pressure in Italian older adults: a cross-sectional study
Coelho‐Júnior, H. J., Calvani, R., Picca, A., Tosato, M., Savera, G., Landi, F., & Marzetti, E. (2023) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02549-x · Cited by 2
“Numerous studies have reported that aerobic training (AT), land-or water-based exercises in which muscle contractions are sustained for long periods [10], ameliorates cardiometabolic risk factors [11–14].”
Background
Cardiac Rehabilitation in Geriatric Individuals
Kutukcu, E. C., Topcuoğlu, C., Ar, U., & Sağlam, M. (2024) · Topics in Geriatric Rehabilitation · doi:10.1097/tgr.0000000000000448 · Cited by 2
Does Self-Reported Physical Activity Underestimate the Importance of Activity in Cardiovascular Disease Prevention?
Anton, S., & Manini, T. M. (2010) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-010-0100-1 · Cited by 2
“Another meta-analyses of 13 studies (17 exercise groups, 14 control) concluded that the average reduction in body weight following an exercise intervention is 0.7 kg [ 41 ].”
BackgroundInfluential
Riesgo residual vascular de origen lipídico. Estrategias para el tratamiento del riesgo residual por dislipidemia aterogénica
Núñez-Cortés, J. M., Pedro‐Botet, J., & Pintó, X. (2011) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2011.07.003 · Cited by 2
EFFECT OF ONE-SESSION ANAEROBIC EXHAUSTIVE EXERCISE ON LIPID PROFILE OF ACTIVE AND INACTIVE INDIVIDUALS
Kashef, M., Karizak, S. Z., & Shabaninia, M. (2014) · مجله علمی پژوهشی افق دانش · Cited by 2
EFFECT OF PROGRESSIVE MUSCLE RELAXATION EXERCISE BASED ON ARDUINO UNO ON BLOOD SUGAR, CHOLESTEROL AND URID ACID LEVELS IN THE ELDERLY
Elfira, E. (2020) · Nurse and Health Jurnal Keperawatan · doi:10.36720/nhjk.v9i2.193 · Cited by 2
Health and Nutrition Analysis in Older Adults in San José de Minas Rural Parish in Quito, Ecuador
Ordóñez-Araque, R., Caicedo-Jaramillo, C., Gálvez, M. M. G., & Proaño-Zavala, J. (2023) · Global Health · doi:10.1155/2023/1839084 · Cited by 1
“In addition, it improves the immune system response, can reduce the risk of falls and cardiovascular diseases, can contribute to a reduction in muscle atrophy, increases the excretion of cholesterol, and consequently reduces the risk of atherosclerosis [4, 6, 7].”
Bénéfices pour la santé de la pratique d’une activité physique chez le sujet âgé
Vogel, T., Lang, P. O., Schmitt, E., Kaltenbach, G., & Gény, B. (2013) · Les cahiers de l année gérontologique · doi:10.1007/s12612-013-0360-8 · Cited by 1
Residual Risk Reduction Initiative: výzva ke snížení reziduálního vaskulárního rizika u pacientů s dyslipidemií
Fruchart, J., Sacks, F. M., Hermans, M. P., Assmann, G., Brown, W. V., Češka, R., Chapman, M. J., Dodson, P. M., Fioretto, P., Ginsberg, H. N., et al. (2010) · Cor et Vasa · doi:10.33678/cor.2010.056 · Cited by 1
Physical Activity and the Mediterranean Diet
Hingle, M. D., Laddu, D., & Going, S. B. (2016) · Springer eBooks · doi:10.1007/978-3-319-27969-5_16 · Cited by 1
“1 %), but not TG [ 55 ] with moderate intensity (55–90 % of maximum heart rate) aerobic activity; increased HDL-C and decreased ratio of TC/HDL-C were the only fractions that remained statistically signifi cant after a sensitivity analysis to identify publication bias ( p < 0.”
Background
AVALIAÇÃO DOS EFEITOS DA ATIVIDADE FÍSICA NA PREVENÇÃO DE DOENÇAS CARDIOVASCULARES
Melo, T. D. P. N., Andrade, P. R. M., Santos, G. A. R., Júnior, L. R. D. A., da Silva, A. K. O., Rodrigues, M. G. D. O., Magalhães, P. R., Magalhães, L. R., do Nascimento, A. L., & de Souza, L. M. (2024) · Revista Ibero-Americana de Humanidades, Ciências e Educação · doi:10.51891/rease.v10i6.13879 · Cited by 1
Exercise Standards for Testing and Training: A Scientific Statement From the American
Rhodes, J., Thompson, P. D., Williams, M. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., Gulati, M., Fletcher, F. M., Ades, P. A., et al. (2013) · Cited by 1
Efeito do treinamento de caminhada sobre o risco, a função e a regulação cardiovasculares em indivíduos com claudicação intermitente
Chehuen, M. D. R. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.39.2014.tde-11052015-095750 · Cited by 1
Comment on: Serum Cholesterol and Incident Alzheimer Disease: Findings From the Adult Changes in Thought Study
Naharcı, M. İ., & Taşçı, İ. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15877 · Cited by 1
“A meta-analysis reported aerobic exercise increases HDL-C and decreases the ratio of total cholesterol to HDL-C in adults aged 50 years or older.(8) In a recent study, Aparicio-Ugarriza et al suggested that physical fitness was associated with improved HDL-C and low-density lipoprotein cholesterol levels in adults age…”
Background
Aerobic Exercise Training and Healthy Aging
Fleg, J. L. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_605-1 · Cited by 1
Weight Loss Versus Behavioral Change as the Primary Goal in Clinical Practice
Vaughan, E. M., & Johnston, C. A. (2015) · American Journal of Lifestyle Medicine · doi:10.1177/1559827615579166
A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation, American Pharmacists Association, American Society for Nutrition, American Society for Preventive Cardiology, American Society of Hypertension, Association of Black Cardiologists, National Lipid Association, Preventive Cardiovascular Nurses Association, and WomenHeart: The National Coalition for Women …
Jakicic, J. M., Ard, D., Miller, N. H., Hubbard, S. M., Nonas, C., Jesus, J. M. D., Sacks, F. M., Lichtenstein, A. H., Svetkey, L. P., Loria, C. M., et al. (2013)

Authors: Kelley, G. A., Kelley, K. S., & Tran, Z. V.
Affiliations: West Virginia University (US)
ORCID: Kelley, George A.
Kelley, Kristi S.
Tran, Zung V.
Venue: Preventive Cardiology
Publisher: Wiley
Published: 2005-09
Volume: 8
Issue: 4
Pages: 206-214
ISSN: 1520-037X (ISSN-L)
1751-7141
DOI: 10.1111/j.0197-3118.2005.03769.x
PMC: PMC2447857
OpenAlex: W2009903068
Cited by: 118
References: 50
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 13 · 2012: 6
FWCI: 1.00
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 516 d)
Locations: Preventive Cardiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL069802)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: aerobic exercise, older adults, lipoproteins, cholesterol, HDL cholesterol, LDL cholesterol, TC/HDL-C ratio, triglycerides, lipid profile, cardiovascular risk
MeSH terms: Female, Humans, Lipids, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Exercise

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exercise, Lipids, and Lipoproteins in Older Adults: A Meta‐Analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks