Long‐Term Modulation By Postnatal Oxytocin of the α2‐Adrenoceptor Agonist Binding Sites in Central Autonomic Regions and the Role of Prenatal Stress
Abstract
The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life-long effects on the alpha(2)-agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus and the amygdala, as evaluated by quantitative receptor autoradiography. Maternal food restriction alone increased the affinity of the alpha(2)-agonist [(3)H]UK14.304 binding sites exclusively in the NTS. In offspring from ad libitum fed dams, oxytocin treatment significantly increased the density of alpha(2)-agonist binding sites in the NTS and in the hypothalamus. The K(d) value of the alpha(2)-agonist binding sites in the hypothalamus of these rats, but not in the other regions studied, was also significantly increased. In offspring from food-restricted dams, oxytocin treatment produced a significant increase of the B(max) values in the hypothalamus and the amygdala and the K(d) value of the alpha(2)-agonist binding sites in the NTS of these rats also was selectively and significantly increased. These results suggest that a postnatal, oxytocin-induced increase of regional alpha(2)-adrenoceptor function can be seen in adulthood by a persistent, regionally selective increase in the density of central alpha(2)-adrenoceptor agonist binding sites, in the absence of an affinity change in the NTS. Such a regional increase of alpha(2)-adrenoceptor signalling in adulthood may contribute to the anti-stress action of postnatal oxytocin. By contrast, after prenatal stress, the potential increase in alpha(2)-adrenoceptor signalling takes place via selective increases of density with no changes of affinity of the alpha(2)-agonist binding sites in the hypothalamus and the amygdala.
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In rats, chronic neonatal oxytocin treatment alters alpha-2 adrenergic receptor kinetics in postnatal day 130 male rats, and these changes are dependent upon the nutrition of the dam.
“In rats, chronic neonatal Oxt treatment alters α2 adrenergic receptor (α2r) kinetics in PND130 male rats; these changes are dependent upon the nutrition of the dam to which the pups were born.”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [83]
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- Authors
- Díaz‐Cabiale, Z., Olausson, H., Sohlström, A., Agnati, L. F., Narváez, J. A., Uvnäs‐Moberg, K., & Fuxe, K.
- Affiliations
- Linköping University (SE)
- University of Modena and Reggio Emilia (IT)
- Karolinska Institutet (SE)
- ORCID
- Uvnäs‐Moberg, K.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2004-03
- Volume
- 16
- Issue
- 3
- Pages
- 183-190
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2079505142
- Cited by
- 23
- References
- 43
- Citations by year
- 2024: 3 · 2023: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2012: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD38490-01, P01HD038490)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, maternal stress, nucleus tractus solitarius, hypothalamus, amygdala, receptor density, receptor binding affinity, anti-stress effects, developmental programming
- MeSH terms
- Aging, Amygdala, Animals, Animals, Newborn, Binding Sites, Brain, Female, Food Deprivation, Hypothalamus, Kinetics, Male, Oxytocin, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Physiological, Rats, Sprague-Dawley, Solitary Nucleus, Autonomic Pathways, Receptors, Adrenergic, alpha-2, Maternal Exposure, Rats, Adrenergic alpha-2 Receptor Agonists
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