Cited by 182Pain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

THIS ARTICLE HAS BEEN RETRACTED Repeated massage‐like stimulation induces long‐term effects on nociception: contribution of oxytocinergic mechanisms

Lund, Iréne, Yu, Long‐Chuan, Uvnas‐Moberg, Kerstin, Wang, Jing, Yu, Cheng, Kurosawa, Mieko, Agren, Greta, Rosén, Annika +2 more·2002·European Journal of Neuroscience

Abstract

Massage‐like stroking induces acute antinociceptive effects that can be reversed by an oxytocin antagonist, indicating activation of oxytocin on endogenous pain controlling systems. We now demonstrate an increase in hindpaw withdrawal latencies (HWLs), in response to thermal and mechanical stimuli, which was present after six treatments of massage‐like stroking every other day and which continued to increase through the remaining seven treatments. Repeated massage‐like stroking also resulted in increased oxytocin‐like immunoreactivity (oxytocin‐LI) levels in plasma and periaquaductal grey matter (PAG). Furthermore, increases in HWLs were also present after injections of oxytocin into the PAG (0.1, 0.5 and 1.0 nmol). Intra‐PAG oxytocin injection of 1 nmol followed by 1 or 20 nmol of naloxone attenuated the increments in HWL. Also, there was a dose‐dependent attenuation of the oxytocin‐induced antinociceptive effects following intra‐PAG injection of the µ‐opioid antagonist β‐funaltrexamine (β‐FNA) and the κ‐opioid antagonist nor‐binaltorphimine (nor‐BNI) but not the δ‐antagonist naltrindole. The long‐term antinociceptive effects of massage‐like stroking may be attributed, at least partly, to the oxytocinergic system and its interaction with the opioid system, especially the µ‐ and the κ‐receptors in the PAG.

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Crossref · 10.1046/j.1460-9568.2002.02087.xThis paper is marked retracted.

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Authors
Lund, I., Yu, L., Uvnas‐Moberg, K., Wang, J., Yu, C., Kurosawa, M., Agren, G., Rosén, A., Lekman, M., & Lundeberg, T.
Affiliations
  • Karolinska Institutet (SE)
  • Peking University (CN)
  • International University of Health and Welfare (JP)
  • Karolinska University Hospital (SE)
Corresponding author
Lund, Iréne
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2002-07
Volume
16
Issue
2
Pages
330-338
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2615596569
Cited by
181
References
41
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 11
FWCI
5.00
Type
journal article
Language
en
Status
Retracted
Open access
closed
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
oxytocin, antinociception, periaqueductal gray, mu-opioid receptor, kappa opioid receptor, opioid system, naloxone, beta-funaltrexamine, nor-binaltorphimine, naltrindole
MeSH terms
Afferent Pathways, Animals, Male, Massage, Mechanoreceptors, Narcotic Antagonists, Nociceptors, Oxytocin, Pain, Periaqueductal Gray, Physical Stimulation, Reaction Time, Time Factors, Rats, Sprague-Dawley, Pain Threshold, Receptors, Opioid, mu, Receptors, Opioid, kappa, Rats

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