The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Metals and amyloid‐β in Alzheimer's disease
Open accessAbstract
Summary: Mounting evidence is demonstrating roles for the amyloid precursor protein (APP) and its proteolytic product Aβ in metal homeostasis. Furthermore, aberrant metal homeostasis is observed in patients with Alzheimer's disease (AD), and this may contribute to AD pathogenesis, by enhancing the formation of reactive oxygen species and toxic Aβ oligomers and facilitating the formation of the hallmark amyloid deposits in AD brain. Indeed, zinc released from synaptic activity has been shown to induce parenchymal and cerebrovascular amyloid in transgenic mice. On the other hand, abnormal metabolism of APP and Aβ may impair brain metal homeostasis as part of the AD pathogenic process. Aβ and APP expression have both been shown to decrease brain copper (Cu) levels, whereas increasing brain Cu availability results in decreased levels of Aβ and amyloid plaque formation in transgenic mice. Lowering Cu concentrations can downregulate the transcription of APP, strengthening the hypothesis that APP and Aβ form part of the Cu homeostatic machinery in the brain. This is a complex pathway, and it appears that when the sensitive metal balance in the brain is sufficiently disrupted, it can lead to the self‐perpetuating pathogenesis of AD. Clinical trials are currently studying agents that can remedy abnormal Aβ–metal interactions.
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Self-citationOligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability
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Self-citationOxidative stress in Alzheimer’s disease
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Biological metals and metal-targeting compounds in major neurodegenerative diseases
Barnham, K. J., & Bush, A. I. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00138a · Cited by 497
Self-citationMetal Toxicity Links to Alzheimer's Disease and Neuroinflammation
Huat, T. J., Camats-Perna, J., Newcombe, E. A., Valmas, N., Kitazawa, M., & Medeiros, R. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.01.018 · Cited by 470
The pyridyl group in ligand design for selective metal ion complexation and sensing
Hancock, R. D. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35224a · Cited by 353
Copper Dyshomeostasis in Neurodegenerative Diseases—Therapeutic Implications
Gromadzka, G., Tarnacka, B., Flaga, A., & Adamczyk, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239259 · Cited by 339
Metadata
- Authors
- Maynard, C. J., Bush, A. I., Masters, C. L., Cappai, R., & Li, Q.
- Venue
- International Journal of Experimental Pathology
- Publisher
- Wiley
- Published
- 2005-05-24
- Volume
- 86
- Issue
- 3
- Pages
- 147-159
- ISSN
- 0959-9673 (ISSN-L)
- 1365-2613
- OpenAlex
- W1707143272
- Cited by
- 353
- References
- 26
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- green
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