The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mood and cognitive effects of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’): week‐end ‘high’ followed by mid‐week low
Abstract
Aims. Recreational use of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is widespread. The present study aimed to examine both the acute and residual effects of this drug on users' mood and cognitive Junction. Design and participants. A parallel group design was used to compare 12 participants who reported having taken MDMA with 12 participants who reported having consumed only alcohol, on the relevant night (day 1). These same participants were then re‐assessed the following day (day 2) and again mid‐week (day 5). Findings. Acute effects of MDMA broadly replicated previous findings. MDMA users rated elevated mood on day 1 but significantly low mood on day 5, at which point some participants scored within the range for clinical depression. In contrast, the alcohol group showed less pronounced changes, which followed a U‐shaped curve over days with the lowest point being day 2. The MDMA group also showed significant impairments on an attentional/working memory task, compared with alcohol users. Conclusions. Weekend use of MDMA may lead to depressed mood mid‐week. Possible mechanisms underlying the findings are discussed in terms of temporary depletion of serotonin, serotonergic neurotoxity and psychological aspects of mood change.
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Cited by
The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
Green, A. R., Mechan, A. O., Elliott, J. M., O’Shea, E., & Colado, M. I. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.3 · Cited by 1,272
Memory impairment in abstinent MDMA ("Ecstasy") users
Bolla, K. I., McCann, U. D., & Ricaurte, G. A. (1998) · Neurology · doi:10.1212/wnl.51.6.1532 · Cited by 373
Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research
Parrott, A. C. (2001) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.351 · Cited by 344
The Physiological Role of 5-HT2AReceptors in Working Memory
Williams, G. V., Rao, S. G., & Goldman-Rakic, P. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02843.2002 · Cited by 311
Impaired cognitive performance in drug free users of recreational ecstasy (MDMA)
Gouzoulis-Mayfrank, E. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.6.719 · Cited by 305
Metadata
- Authors
- CURRAN, H. V., & TRAVILL, R. A.
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 1997-07
- Volume
- 92
- Issue
- 7
- Pages
- 821-831
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- OpenAlex
- W2160059442
- Cited by
- 282
- References
- 1
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CURRAN, H. V., & TRAVILL, R. A. (1997). Mood and cognitive effects of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’): week‐end ‘high’ followed by mid‐week low. Addiction. https://doi.org/10.1111/j.1360-0443.1997.tb02951.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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