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Mood and cognitive effects of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’): week‐end ‘high’ followed by mid‐week low

CURRAN, H. VALERIE, TRAVILL, ROSS A.·1997·Addiction

Abstract

Aims. Recreational use of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is widespread. The present study aimed to examine both the acute and residual effects of this drug on users' mood and cognitive Junction. Design and participants. A parallel group design was used to compare 12 participants who reported having taken MDMA with 12 participants who reported having consumed only alcohol, on the relevant night (day 1). These same participants were then re‐assessed the following day (day 2) and again mid‐week (day 5). Findings. Acute effects of MDMA broadly replicated previous findings. MDMA users rated elevated mood on day 1 but significantly low mood on day 5, at which point some participants scored within the range for clinical depression. In contrast, the alcohol group showed less pronounced changes, which followed a U‐shaped curve over days with the lowest point being day 2. The MDMA group also showed significant impairments on an attentional/working memory task, compared with alcohol users. Conclusions. Weekend use of MDMA may lead to depressed mood mid‐week. Possible mechanisms underlying the findings are discussed in terms of temporary depletion of serotonin, serotonergic neurotoxity and psychological aspects of mood change.

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Metadata

Authors
CURRAN, H. V., & TRAVILL, R. A.
Venue
Addiction
Publisher
Wiley
Published
1997-07
Volume
92
Issue
7
Pages
821-831
ISSN
  • 0965-2140 (ISSN-L)
  • 1360-0443
OpenAlex
W2160059442
Cited by
282
References
1
FWCI
14.19
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Mood and cognitive effects of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’): week‐end ‘high’ followed by mid‐week low. https://app.cochat.ai/papers/10.1111/j.1360-0443.1997.tb02951.x
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CURRAN, H. V., & TRAVILL, R. A. (1997). Mood and cognitive effects of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’): week‐end ‘high’ followed by mid‐week low. Addiction. https://doi.org/10.1111/j.1360-0443.1997.tb02951.x

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