The Physiological Role of 5-HT2AReceptors in Working Memory
Open accessAbstract
Dorsolateral prefrontal cortex has an essential role in the cognitive process of working memory, dysfunction of which is considered to be a core deficit in schizophrenia. Although this cortical region is densely innervated with 5-HT 2A receptors to which atypical antipsychotic drugs bind with high affinity, little is known of the influence of this serotonin receptor subtype on prefrontal function. We addressed this issue by examining the effects of iontophoresis of selective receptor ligands on prefrontal neurons possessing spatially tuned delay activity, or “memory fields,” in monkeys performing a delayed-response task. Memory fields of putative pyramidal cells were attenuated by iontophoresis of 5-HT 2A antagonists, which primarily produced a reduction in delay activity for preferred target locations. Conversely, 5-HT 2A stimulation by α-methyl-5-HT or 5-HT itself, accentuated the spatial tuning of these neurons by producing a modest increase in activity for preferred target locations and/or a reduction in activity for nonpreferred locations. The agonist effects could be reversed by the selective antagonist MDL100,907, and were dose-dependent, such that high levels attenuated spatial tuning by profoundly reducing delay activity. A role for feedforward inhibitory circuitry in these effects was supported by the finding that 5-HT 2A blockade also attenuated the memory fields of putative interneurons. We conclude that prefrontal 5-HT 2A receptors have a hitherto unrecognized role in the cognitive function of working memory, which involves actions at both excitatory and inhibitory elements within local circuitry.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
High levels of 5-HT2A receptor stimulation can suppress dorsolateral PFC neuronal firing in monkeys performing a working memory task.
“one study has shown that high levels of 5-HT2A receptor stimulation can suppress dorsolateral PFC neuronal firing in monkeys performing a working memory task161.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [161]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Practical Nonparametric Statistics
Groggel, D. J., & Conover, W. J. (2000) · Technometrics · doi:10.2307/1271101 · Cited by 11,071 · see citing works
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685 · see citing works
Self-citationCellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663 · see citing works
Self-citationStatistical Analysis of Circular Data.
LANGE, N. D., & Fisher, N. I. (1995) · Journal of the American Statistical Association · doi:10.2307/2291098 · Cited by 2,155 · see citing works
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,019 · see citing works
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960 · see citing works
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick, D. A., Connors, B. W., Lighthall, J. W., & Prince, D. A. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.4.782 · Cited by 1,935 · see citing works
Statistical Analysis of Circular Data
Fisher, N. I. (1993) · Cambridge University Press eBooks · doi:10.1017/cbo9780511564345 · Cited by 1,826 · see citing works
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593 · see citing works
Self-citationRogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101 · see citing works
Working memory dysfunction in schizophrenia
(1994) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.6.4.348 · Cited by 1,068 · see citing works
Self-citationThe Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia
Meltzer, H. Y., & McGurk, S. R. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033376 · Cited by 1,022 · see citing works
Fuster, J. M. (1973) · Journal of Neurophysiology · doi:10.1152/jn.1973.36.1.61 · Cited by 995 · see citing works
Schizophrenics Show Spatial Working Memory Deficits
Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 946 · see citing works
A cytoarchitectural study of the prefrontal area of the macaque monkey
Walker, A. E. (1940) · The Journal of Comparative Neurology · doi:10.1002/cne.900730106 · Cited by 803 · see citing works
Zahrt, J., Taylor, J. R., Mathew, R. G., & Arnsten, A. F. T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08528.1997 · Cited by 796 · see citing works
Response properties of vibrissa units in rat SI somatosensory neocortex
Simons, D. J. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.3.798 · Cited by 771 · see citing works
Mountcastle, V. B., Talbot, W. H., Sakata, H., & Hyvärinen, J. (1969) · Journal of Neurophysiology · doi:10.1152/jn.1969.32.3.452 · Cited by 683 · see citing works
The Role of Serotonin in Antipsychotic Drug Action
Meltzer, H. M. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00046-9 · Cited by 664 · see citing works
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works
Meltzer, H. Y. (1989) · Psychopharmacology · doi:10.1007/bf00442554 · Cited by 604 · see citing works
Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients
Andreasen, N. C., OʼLeary, D. S., Flaum, M. A., Nopoulos, P., Watkins, G. L., Ponto, L. L. B., & Hichwa, R. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)08258-x · Cited by 597 · see citing works
Murphy, B. L., Arnsten, A. F., Goldman-Rakic, P. S., & Roth, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1325 · Cited by 590 · see citing works
Self-citationDopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys
Arnsten, A. F. T., Cai, J. X., Murphy, B. L., & Goldman-Rakic, P. S. (1994) · Psychopharmacology · doi:10.1007/bf02245056 · Cited by 566 · see citing works
Self-citationCortex and memory: emergence of a new paradigm
Fuster, J. M. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21280 · Cited by 559 · see citing works
Schizophrenic syndromes, cognitive performance and neurological dysfunction
Liddle, P. F. (1987) · Psychological Medicine · doi:10.1017/s0033291700012976 · Cited by 552 · see citing works
Jakab, R. L., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.735 · Cited by 536 · see citing works
Kawaguchi, Y. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02638.1995 · Cited by 533 · see citing works
Serotonin model of schizophrenia: emerging role of glutamate mechanisms
Aghajanian, G. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00046-6 · Cited by 529 · see citing works
Aghajanian, G. K., & Marek, G. J. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00051-8 · Cited by 516 · see citing works
Schizophrenic Syndromes and Frontal Lobe Performance
Liddle, P. F., & Morris, D. L. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.158.3.340 · Cited by 507 · see citing works
Ichikawa, J., Ishii, H., Bonaccorso, S., Fowler, W. L., O'Laughlin, I. A., & Meltzer, H. Y. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00154.x · Cited by 495 · see citing works
McCarthy, G., Blamire, A. M., Puce, A., Nobre, A. C., Bloch, G., Hyder, F., Goldman-Rakic, P., & Shulman, R. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8690 · Cited by 459 · see citing works
Self-citationTimofeev, I., Grenier, F., & Steriade, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1924 · Cited by 455 · see citing works
Vollenweider, F. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00246-1 · Cited by 444 · see citing works
Relapse of depression after rapid depletion of tryptophan
Smith, K., Fairburn, C. G., & Cowen, P. J. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07044-4 · Cited by 428 · see citing works
Rao, S. G., Williams, G. V., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00485.2000 · Cited by 407 · see citing works
Self-citationCastner, S. A., Williams, G. V., & Goldman, P. S. (2000) · Science · doi:10.1126/science.287.5460.2020 · Cited by 401 · see citing works
Self-citationMcCarthy, G., Puce, A., Constable, R. T., Krystal, J. H., Gore, J. C., & Goldman‐Rakic, P. S. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.4.600 · Cited by 397 · see citing works
Self-citationKawaguchi, Y. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.2.416 · Cited by 390 · see citing works
Aghajanian, G. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00135-3 · Cited by 371 · see citing works
Porrino, L. J., & Goldman, P. S. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902050107 · Cited by 363 · see citing works
Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman‐Rakic, P. S. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.65.6.1464 · Cited by 358 · see citing works
Self-citationKuroki, T., Meltzer, H. Y., & Ichikawa, J. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38019-x · Cited by 351 · see citing works
Rao, S. G., Williams, G. V., & Goldman, P. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.4.1903 · Cited by 335 · see citing works
Self-citationLaminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons
Dantzker, J. L. M., & Callaway, E. M. (2000) · Nature Neuroscience · doi:10.1038/76656 · Cited by 303 · see citing works
Wilson, F. A. W., ÓScalaidhe, S. P., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4009 · Cited by 303 · see citing works
Self-citationSchreiber, R., Brocco, M., Audinot, V., Gobert, A., Veiga, S., & Millan, M. J. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09485-6 · Cited by 300 · see citing works
Luciana, M., Collins, P., & Depue, R. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.3.218 · Cited by 291 · see citing works
Curran, H. V., & Travill, R. A. (1997) · Addiction · doi:10.1111/j.1360-0443.1997.tb02951.x · Cited by 284 · see citing works
The functional anatomy of auditory hallucinations in schizophrenia
Lennox, B. R., Park, S. B. G., Medley, I., Morris, P. G., & Jones, P. B. (2000) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00068-8 · Cited by 277 · see citing works
Bremner, J. D. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830160092012 · Cited by 273 · see citing works
Prefrontal cortex fMRI signal changes are correlated with working memory load
Manoach, D. S., Schlaug, G., Siewert, B., Darby, D. G., Bly, B. M., Benfield, A., Edelman, R. R., & Warach, S. (1997) · NeuroReport · doi:10.1097/00001756-199701200-00033 · Cited by 261 · see citing works
Activation of Serotonin Receptors Modulates Synaptic Transmission in Rat Cerebral Cortex
Zhou, F.-M., & Hablitz, J. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.2989 · Cited by 238 · see citing works
Morrison, J. H., Foote, S. L., Molliver, M. E., Bloom, F. E., & Lidov, H. G. W. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.7.2401 · Cited by 211 · see citing works
The cerebral cortex: a case for a common site of action of antipsychotics
Lidow, M. S., Williams, G. V., & Goldman‐Rakic, P. S. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01186-9 · Cited by 206 · see citing works
Self-citationBaeg, E. H. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.5.441 · Cited by 205 · see citing works
Aghajanian, G. K., & Marek, G. (1999) · Neuropsychopharmacology · doi:10.1038/sj.npp.1395318 · Cited by 199 · see citing works
Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex
Tanaka, E., & NORTH, R. A. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.5.1749 · Cited by 187 · see citing works
霊長類大脳皮質の5‐ヒドロキシトリプタミン2Aセロトニン受容体 錐体細胞先端樹状突起での幻覚剤及び抗精神病剤の作用部位
Jakab, R. L., & Goldman‐Rakic, P. S. (1998) · Cited by 182 · see citing works
Self-citationJakab, R. L., & Goldman, P. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000214)417:3 · Cited by 180 · see citing works
Swadlow, H. A., Beloozerova, I. N., & Sirota, M. G. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.567 · Cited by 160 · see citing works
Gellman, R. L., & Aghajanian, G. K. (1993) · Brain Research · doi:10.1016/0006-8993(93)90402-9 · Cited by 160 · see citing works
Farde, L., Nyberg, S., Oxenstierna, G., Nakashima, Y., Halldin, C., & ERICSSON, B. (1995) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199502001-00004 · Cited by 157 · see citing works
Marek, G. J., & Aghajanian, G. K. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20792-3 · Cited by 152 · see citing works
Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization.
Iyer, R. N., & Bradberry, C. W. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12836-x · Cited by 131 · see citing works
Sheldon, P. W., & Aghajanian, G. K. (1991) · Synapse · doi:10.1002/syn.890090307 · Cited by 131 · see citing works
Shimegi, S., Ichikawa, T., Akasaki, T., & Sato, H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-10164.1999 · Cited by 104 · see citing works
Rajkowska, G. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)26026-3 · Cited by 99 · see citing works
Morris, N. P., & Henderson, Z. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00970.x · Cited by 98 · see citing works
Hindmarch, I., Kimber, S., & Cockle, S. M. (2000) · International Clinical Psychopharmacology · doi:10.1097/00004850-200015060-00001 · Cited by 84 · see citing works
Takeuchi, Y., & Sano, Y. (1983) · Anatomy and Embryology · doi:10.1007/bf00305080 · Cited by 81 · see citing works
[3H]MDL 100,907: a novel selective 5-HT2A receptor ligand
Johnson, M., Siegel, B., & Carr, A. (1996) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00178722 · Cited by 80 · see citing works
Gellman, R. L., & Aghajanian, G. K. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90077-9 · Cited by 80 · see citing works
D1-, D2-, and 5-HT2-receptor occupancy in clozapine-treated patients.
Farde, L., Nordström, A., Nyberg, S., Halldin, C., & Sedvall, G. (1994) · PubMed · Cited by 79 · see citing works
Ruotsalainen, S., Sirviö, J., Jäkälä, P., Puumala, T., MacDonald, E., & Riekkinen, P. J. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(96)00389-6 · Cited by 62 · see citing works
Isabella, P. D., Palumbo, M., Sissi, C., Capranico, G., Carenini, N., Menta, E., Oliva, A., Spinelli, S., Krapcho, A. P., & Giuliani, F. C. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10042-4 · Cited by 59 · see citing works
Regional distribution of neurotrophin receptors in the developing auditory brainstem
Hafidi, A., Moore, T., & Sanes, D. H. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960408)367:3 · Cited by 51 · see citing works
Sabri, O., Hellwig, D., Schreckenberger, M., Cremerius, U., Schneider, R., Kaiser, H. J., Doherty, C., Mull, M., Ringelstein, E. B., & Buell, U. (1998) · PubMed · Cited by 47 · see citing works
Gur, M., Beylin, A., & Snodderly, D. M. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.3.1451 · Cited by 41 · see citing works
Mazzola‐Pomietto, P., Aulakh, C. S., Woźniak, K., & Murphy, D. L. (1996) · Psychopharmacology · doi:10.1007/bf02246643 · Cited by 39 · see citing works
Garnovskaya, M. N., Nebigil, C. G., Arthur, J. M., Spurney, R. F., & Raymond, J. R. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10241-1 · Cited by 39 · see citing works
Effects of p-chlorophenylalanine and methysergide on the performance of a working memory task
Jäkälä, P., Sirviö, J., Riekkinen, P. J., & Riekkinen, P. J. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90483-a · Cited by 37 · see citing works
Wahlbeck, K., Nikkilä, H. V., Rimón, R., & Ahokas, A. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(99)00125-0 · Cited by 20 · see citing works
The influence of prolactin response to d-fenfluramine on executive functioning in major depression
Degl’Innocenti, A., Ågren, H., Zachrisson, O., & Bäckman, L. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00325-4 · Cited by 10 · see citing works
Lundberg, T., Lindström, L., Hartvig, P., Reibring, L., Ågren, H., Lundqvist, H., Fasth, K. J., Antoni, G., & Långström, B. (1996) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(96)02653-4 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 87 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762 · see citing works
Nichols, D. E. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.11.002 · Cited by 1,211 · see citing works
Roth, B. L., Sheffler, D. J., & Kroeze, W. K. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1346 · Cited by 1,155 · see citing works
Metalearning and neuromodulation
Doya, K. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00044-8 · Cited by 704 · see citing works
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 549 · see citing works
The therapeutic role of 5-HT1A and 5-HT2A receptors in depression
Celada, P., Puig, M. V., Amargós‐Bosch, M., Adell, A., & Artigas, F. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0427 · Cited by 523 · see citing works
Santana, N. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh070 · Cited by 486 · see citing works
Serotonin modulation of cortical neurons and networks
Celada, P., Puig, M. V., & Artigas, F. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00025 · Cited by 462 · see citing works
Hasler, F., Grimberg, U., Benz, M. A., Huber, T., & Vollenweider, F. X. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1640-6 · Cited by 451 · see citing works
Serotonin and Prefrontal Cortex Function: Neurons, Networks, and Circuits
Puig, M. V., & Gulledge, A. T. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8214-0 · Cited by 421 · see citing works
The role of serotonin 5-HT2A receptors in memory and cognition
Zhang, G., & Stackman, R. W. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00225 · Cited by 386 · see citing works
Amargos-Bosch, M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg128 · Cited by 370 · see citing works
Prefrontal Serotonin Depletion Affects Reversal Learning But Not Attentional Set Shifting
Clarke, H. F., Walker, S. C., Crofts, H. S., Dalley, J. W., Robbins, T. W., & Roberts, A. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3690-04.2005 · Cited by 358 · see citing works
Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350 · see citing works
Working Memory in the Prefrontal Cortex
Funahashi, S. (2017) · Brain Sciences · doi:10.3390/brainsci7050049 · Cited by 339 · see citing works
Under the curve: Critical issues for elucidating D1 receptor function in working memory
Williams, G. V., & Castner, S. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.028 · Cited by 326 · see citing works
Self-citationPersistent neural activity: prevalence and mechanisms
Major, G., & Tank, D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.017 · Cited by 320 · see citing works
Selective D2 receptor actions on the functional circuitry of working memory
Wang, M., Vijayraghavan, S., & Goldman-Rakic, P. S. (2004) · Science · doi:10.1126/science.1091162 · Cited by 319 · see citing works
Self-citationKrystal, J. H., Perry, E. B., Gueorguieva, R., Belger, A., Madonick, S. H., Abi-Dargham, A., Cooper, T. B., MacDougall, L., Abi-Saab, W., & D’Souza, D. C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.9.985 · Cited by 317 · see citing works
Recent advances in the neuropsychopharmacology of serotonergic hallucinogens
Halberstadt, A. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.016 · Cited by 312 · see citing works
Bouso, J. C., González, D., Fondevila, S., Cutchet, M., Fernández, X., Ribeiro Barbosa, P. C., Alcázar-Córcoles, M. Á., Araújo, W. S., Barbanoj, M. J., Fábregas, J. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042421 · Cited by 313 · see citing works
Revisiting the role of neurotransmitters in epilepsy: An updated review.
Akyuz, E., Polat, A., Eroğlu, E., Kullu, I., Angelopoulou, E., & Paudel, Y. (2020) · Life Science · doi:10.1016/j.lfs.2020.118826 · Cited by 269 · see citing works
The paradoxical psychological effects of lysergic acid diethylamide LSD
Carhart-Harris, R. L., Kaelen, M., Bolstridge, M., Williams, T. M., Williams, L. T., Underwood, R., Feilding, A., & Nutt, D. J. (2016) · Psychological Medicine · doi:10.1017/s0033291715002901 · Cited by 293 · see citing works
Bockaert, J., Claeysen, S., Bécamel, C., Dumuis, A., & Marin, P. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0286-1 · Cited by 285 · see citing works
Schizophrenia: from phenomenology to neurobiology
Wong, A. H. C., & Tol, H. H. M. V. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00035-6 · Cited by 282 · see citing works
Psychedelics as anti-inflammatory agents
Flanagan, T. W., & Nichols, C. D. (2018) · International Review of Psychiatry · doi:10.1080/09540261.2018.1481827 · Cited by 267 · see citing works
The serotonergic system in ageing and Alzheimer's disease
Rodriguez, J. J., Noristani, H. N., & Verkhratsky, A. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.010 · Cited by 266 · see citing works
GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon
Guidotti, A., Auta, J., Davis, J. M., Dong, E., Grayson, D. R., Veldic, M., Zhang, X., & Costa, E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2212-8 · Cited by 262 · see citing works
Roth, B., Hanizavareh, S. M., & Blum, A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1683-8 · Cited by 259 · see citing works
Kugaya, A., Epperson, C. N., Zoghbi, S. S., van Dyck, C. H., Hou, Y., Fujita, M., Staley, J. K., Garg, P., Seibyl, J. P., & Innis, R. B. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1522 · Cited by 256 · see citing works
Winstanley, C. A., Chudasama, Y., Dalley, J. W., Theobald, D. E. H., Glennon, J. C., & Robbins, T. W. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1398-x · Cited by 234 · see citing works
Carter, O. L., Burr, D. C., Pettigrew, J. D., Wallis, G. M., Hasler, F., & Vollenweider, F. X. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/089892905774597191 · Cited by 231 · see citing works
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh104 · Cited by 232 · see citing works
Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease
Holmes, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.006 · Cited by 264 · see citing works
Molecular Targets for Treating Cognitive Dysfunction in Schizophrenia
Gray, J. A., & Roth, B. L. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm074 · Cited by 225 · see citing works
Puig, M. V. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.8.870 · Cited by 223 · see citing works
Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia
Castner, S., Goldman-Rakic, P., & Williams, G. V. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1710-9 · Cited by 217 · see citing works
Self-citationPuig, M. V., Watakabe, A., Ushimaru, M., Yamamori, T., & Kawaguchi, Y. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3335-09.2010 · Cited by 200 · see citing works
Cools, R., & Arnsten, A. F. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01100-8 · Cited by 206 · see citing works
Role of the Serotonin 5-HT2AReceptor in LearningPreprint
Harvey, J. A. (2003) · Learning & Memory · doi:10.1101/lm.60803 · Cited by 200 · see citing works
COURTNEY, S. M. (2004) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.4.4.501 · Cited by 198 · see citing works
Carli, M., Baviera, M., Invernizzi, R. W., & Balducci, C. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300893 · Cited by 187 · see citing works
Romanski, L. M. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm099 · Cited by 165 · see citing works
Llado-Pelfort, L., Santana, N., Ghisi, V., Artigas, F., & Celada, P. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr220 · Cited by 156 · see citing works
Adverse Effects of Risperidone on Spatial Working Memory in First-Episode Schizophrenia
Reilly, J. L., Harris, M. S. H., Keshavan, M. S., & Sweeney, J. A. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1189 · Cited by 154 · see citing works
In Vivo Excitation of GABA Interneurons in the Medial Prefrontal Cortex through 5-HT3 Receptors
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh097 · Cited by 153 · see citing works
Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning
Barre, A., Berthoux, C., De Bundel, D., Valjent, E., Bockaert, J., Marin, P., & Bécamel, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525586113 · Cited by 135 · see citing works
Serotonin/dopamine interaction in memory formation
González‐Burgos, I., & Feria‐Velasco, A. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00928-x · Cited by 131 · see citing works
The Neuromodulatory System: A Framework for Survival and Adaptive Behavior in a Challenging World
Krichmar, J. L. (2008) · Adaptive Behavior · doi:10.1177/1059712308095775 · Cited by 132 · see citing works
Neural activity in prefrontal cortex during copying geometrical shapes
Averbeck, B. B., Crowe, D. A., Chafee, M. V., & Georgopoulos, A. P. (2003) · Experimental Brain Research · doi:10.1007/s00221-003-1417-5 · Cited by 131 · see citing works
Antagonism of serotonergic 5‐HT2A/2Creceptors: mutual improvement of sleep, cognition and mood?
Landolt, H., & Wehrle, R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06718.x · Cited by 129 · see citing works
Drug targets for cognitive enhancement in neuropsychiatric disorders.
Wallace, T. L., Ballard, T. M., Pouzet, B., Riedel, W. J., & Wettstein, J. G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.022 · Cited by 127 · see citing works
Selective serotonergic excitation of callosal projection neurons
Avesar, D., & Gulledge, A. T. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00012 · Cited by 122 · see citing works
Rasmussen, H., Erritzøe, D., Andersen, R., Ebdrup, B. H., Aggernæs, B., Oranje, B., Kalbitzer, J., Madsen, J., Pinborg, L. H., Baaré, W. F. C., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.176 · Cited by 123 · see citing works
Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments
Schmidt, A., Bachmann, R., Kometer, M., Csomor, P. A., Stephan, K. E., Seifritz, E., & Vollenweider, F. X. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.261 · Cited by 121 · see citing works
Terry, A. V., Buccafusco, J. J., & Wilson, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.12.006 · Cited by 122 · see citing works
Reduced 5-HT2A receptor binding in patients with mild cognitive impairment
Hasselbalch, S. G., Madsen, K., Svarer, C., Pinborg, L. H., Holm, S., Paulson, O. B., Waldemar, G., & Knudsen, G. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.011 · Cited by 122 · see citing works
Passetti, F., Dalley, J. W., & Robbins, T. W. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1227-7 · Cited by 121 · see citing works
Effects of chronic stress on cognitive function – From neurobiology to intervention
Girotti, M., Bulin, S. E., & Carreno, F. R. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100670 · Cited by 142 · see citing works
Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
Lorke, D. E., Lü, G., Cho, E. Y. P., & Yew, D. T. W. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-36 · Cited by 113 · see citing works
Molecular activity underlying working memoryPreprint
Dash, P. K., Moore, A. N., Kobori, N., & Runyan, J. D. (2007) · Learning & Memory · doi:10.1101/lm.558707 · Cited by 113 · see citing works
Carbon, M., Ma, Y.-L., Barnes, A., Dhawan, V., Chaly, T., Ghilardi, M., & Eidelberg, D. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.014 · Cited by 119 · see citing works
de Almeida, J., & Mengod, G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04768.x · Cited by 109 · see citing works
Thinking and hallucinating: Reciprocal changes in sleep
Fosse, R., Stickgold, R., & Hobson, J. A. (2003) · Psychophysiology · doi:10.1111/j.1469-8986.2003.00146.x · Cited by 105 · see citing works
The cortical serotonin2Areceptor and the pathology of schizophrenia: a likely accomplice
Dean, B. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01693.x · Cited by 100 · see citing works
The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003
Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht195 · Cited by 94 · see citing works
Bouso, J. C., Fábregas, J. M., Antonijoan, R. M., Rodríguez-Fornells, A., & Riba, J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3167-9 · Cited by 96 · see citing works
Aznar, S., & Hervig, M. E.-S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.008 · Cited by 95 · see citing works
Atypical Antipsychotics: Matching Receptor Profile to Individual Patient's Clinical Profile
Shayegan, D. K., & Stahl, S. M. (2004) · CNS Spectrums · doi:10.1017/s1092852900025086 · Cited by 94 · see citing works
5-HT2A receptor density is decreased in the at-risk mental state
Hurlemann, R., Matusch, A., Kuhn, K.-U., Berning, J., Elmenhorst, D., Winz, O., Kölsch, H., Zilles, K., Wagner, M., Maier, W., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0921-x · Cited by 98 · see citing works
Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia
Reilly, J. L., Harris, M. S. H., Khine, T. T., Keshavan, M. S., & Sweeney, J. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.031 · Cited by 91 · see citing works
Dawson, N., MORRIS, B. J., & Pratt, J. A. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr144 · Cited by 90 · see citing works
Xia, Z., Hufeisen, S. J., Gray, J. A., & Roth, B. L. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00589-x · Cited by 87 · see citing works
Alzheimer's disease and age-related memory decline (preclinical)
Terry, A. V., Callahan, P. M., Hall, B. J., & Webster, S. J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.002 · Cited by 86 · see citing works
Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder
Murnane, K. S. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000459 · Cited by 85 · see citing works
Synaptic plasticity model of therapeutic sleep deprivation in major depression
Wolf, E., Kühn, M., Normann, C., Mainberger, F., Maier, J. G., Maywald, S., Bredl, A., Klöppel, S., Biber, K. P. H., van Calker, D., et al. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.11.003 · Cited by 87 · see citing works
Zhong, P., Liu, W., Gu, Z., & Yan, Z. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.155143 · Cited by 83 · see citing works
Structure–activity relationships of serotonin 5‐HT2Aagonists
Nichols, D. E. (2012) · Wiley Interdisciplinary Reviews Membrane Transport and Signalling · doi:10.1002/wmts.42 · Cited by 82 · see citing works
Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex
Zhang, Z., & Arsenault, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.086066 · Cited by 82 · see citing works
BERG, K., Harvey, J., Spampinato, U., & Clarke, W. P. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00914-x · Cited by 81 · see citing works
Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex
Nocjar, C., Alex, K. D., Sonneborn, A., Abbas, A. I., Roth, B. L., & Pehek, E. A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.050 · Cited by 81 · see citing works
Raghanti, M. A., Stimpson, C. D., Marcinkiewicz, J. L., Erwin, J. M., Hof, P. R., & Sherwood, C. C. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm089 · Cited by 81 · see citing works
Poyurovsky, M. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00155-4 · Cited by 80 · see citing works
Johnson, O., Becnel, J., & Nichols, C. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.058 · Cited by 85 · see citing works
5-HT systems: emergent targets for memory formation and memory alterations
Meneses, A. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0026 · Cited by 79 · see citing works
Wagner, M., Quednow, B. B., Westheide, J., Schlaepfer, T. E., Maier, W., & Kühn, K.-U. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300626 · Cited by 79 · see citing works
Nichols, C. D. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20370 · Cited by 77 · see citing works
Quirk, M. C. (2009) · Frontiers in Systems Neuroscience · doi:10.3389/neuro.06.013.2009 · Cited by 76 · see citing works
Modulation of Neuronal Excitability by Serotonin-NMDA Interactions in Prefrontal Cortex
Zhong, P., Yuen, E. Y., & Yan, Z. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.03.003 · Cited by 71 · see citing works
Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses
Berthoux, C., Barre, A., Bockaert, J., Marin, P., & Bécamel, C. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy064 · Cited by 68 · see citing works
Molecular mechanisms of working memory
Khan, Z. U., & Muly, E. C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.039 · Cited by 71 · see citing works
The anatomy and physiology of the ocular motor system
Horn, A. K. E., & Leigh, R. J. (2011) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52903-9.00008-x · Cited by 67 · see citing works
Kim, B. S., Lee, J., Bang, M., Seo, B. A., Khalid, A., Jung, M. W., & Jeon, D. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3581-7 · Cited by 65 · see citing works
Nichols, D. E., Frescas, S. P., Chemel, B. R., Rehder, K. S., Zhong, D., & Lewin, A. H. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.04.050 · Cited by 65 · see citing works
Serotonergic Modulation of Plasticity of the Auditory Cortex Elicited by Fear Conditioning
Ji, W., & Suga, N. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5528-06.2007 · Cited by 65 · see citing works
Dremencov, E., Gur, E., Lerer, B., & Newman, M. E. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00123-4 · Cited by 65 · see citing works
Komlósi, G., Molnár, G., Rózsa, M., Oláh, S., Barzó, P., & Tamás, G. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2618-12.2012 · Cited by 57 · see citing works
Parrish, J. C., & Nichols, D. E. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04173.x · Cited by 63 · see citing works
Gresch, P. J., Smith, R. L., Barrett, R. J., & Sanders-Bush, E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300711 · Cited by 62 · see citing works
- Authors
- Williams, G. V., Rao, S. G., & Goldman-Rakic, P. S.
- Affiliations
- Yale University (US)
- ORCID
- Williams, Graham V.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-04-01
- Volume
- 22
- Issue
- 7
- Pages
- 2843-2854
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6758292
- OpenAlex
- W1635746382
- Cited by
- 311
- References
- 87
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 13 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 8 · 2019: 5 · 2018: 10 · 2017: 10 · 2016: 14 · 2015: 14 · 2014: 13 · 2013: 12 · 2012: 10
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 44866, R37MH038546, P50MH044866)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 5-HT2A receptor, serotonin, working memory, dorsolateral prefrontal cortex, delay activity, memory field, pyramidal neurons, interneurons, feedforward inhibition, schizophrenia, atypical antipsychotics, alpha-methyl-5-HT, spatial tuning, delayed response task, iontophoresis
- MeSH terms
- Action Potentials, Animals, Cognition, Fixation, Ocular, Iontophoresis, Ligands, Macaca mulatta, Male, Memory, Short-Term, Neurons, Photic Stimulation, Reaction Time, Receptors, Serotonin, Saccades, Serotonin Antagonists, Serotonin Receptor Agonists, Prefrontal Cortex, Pyramidal Cells, Receptor, Serotonin, 5-HT2A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review