Reinstatement of punishment-suppressed opioid self-administration in rats: an alternative model of relapse to drug abuse
Abstract
Rationale Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction.Objectives This study examined the ability of response-independent reinforcer delivery (priming) to reinstate food- or drug-reinforced responding that had been suppressed by response-contingent footshock (punishment).Methods Nose-poke responding by separate groups of rats was reinforced with food (45 mg/delivery) or intravenous remifentanil (4 micro g/kg per infusion), a short-acting micro -opioid agonist. After either 3 or 27 days of training (with 100 reinforcers/day), a punishment contingency was introduced that rapidly suppressed responding. Then, the punishment contingency was discontinued, and half the rats received priming.Results Priming by non-contingent delivery of food or remifentanil significantly reduced the number of sessions required for responding to resume. There were no significant differences in this effect between short-term and long-term training or between food- and drug-trained groups.Conclusions Self-administration responding that has been suppressed by punishment can be reinstated by priming, and it can eventually resume even without priming. Under the conditions studied here, priming after punishment had effects qualitatively similar to those typically seen after extinction. This punishment/reinstatement procedure may be useful for comparing the effects of other manipulations known to affect behavior in the extinction/reinstatement model of relapse.
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In instrumental learning, a behavior punished by response-contingent footshock is reinstated with free presentations of the original reinforcer.
“in instrumental learning, a behavior that has been punished by presenting a response-contingent footshock is also reinstated with free presentations of the original reinforcer (e.g., Panlilio et al., 2003)”
From Context, attention, and the switch between habit and goal-direction in behavior (2021) · cites this paper as Panlilio et al., 2003
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The Effects of Environmental Enrichment on Abstinence and Relapse Using an Animal Conflict Model
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Neural signatures of opioid-induced risk-taking behavior in the prelimbic prefrontal cortexPreprint
Quave, C. B., Vasquez, A. M., Aquino-Miranda, G., Marín, M., Bora, E. P., Chidomere, C. L., Zhang, X. O., Engelke, D. S., & Monte, F. H. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.05.578828
Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats
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- Authors
- Panlilio, L. V., Thorndike, E. B., & Schindler, C. W.
- Affiliations
- National Institutes of Health (US)
- National Institute on Drug Abuse (US)
- Corresponding author
- Panlilio, Leigh V.
- Venue
- Psychopharmacology
- Published
- 2002-08-09
- Volume
- 168
- Issue
- 1-2
- Pages
- 229-235
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2037711350
- Cited by
- 82
- References
- 35
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 2 · 2012: 4
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- reinstatement, punishment, opioid self-administration, priming, remifentanil, footshock, extinction
- MeSH terms
- Remifentanil, Analgesics, Opioid, Animals, Disease Models, Animal, Male, Piperidines, Punishment, Self Administration, Substance-Related Disorders, Rats, Long-Evans, Rats, Secondary Prevention
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