Candidate genes for cannabis use disorders: findings, challenges and directions.
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AIM: Twin studies have shown that cannabis use disorders (abuse/dependence) are highly heritable. This review aims to: (i) review existing linkage studies of cannabis use disorders and (ii) review gene association studies, to identify potential candidate genes, including those that have been tested for composite substance use disorders and (iii) to highlight challenges in the genomic study of cannabis use disorders. METHODS: Peer-reviewed linkage and candidate gene association studies are reviewed. RESULTS: Four linkage studies are reviewed: results from these have homed in on regions on chromosomes 1, 3, 4, 9, 14, 17 and 18, which harbor candidates of predicted biological relevance, such as monoglyceride lipase (MGLL) on chromosome 3, but also novel genes, including ELTD1[epidermal growth factor (EGF), latrophilin and seven transmembrane domain containing 1] on chromosome 1. Gene association studies are presented for (a) genes posited to have specific influences on cannabis use disorders: CNR1, CB2, FAAH, MGLL, TRPV1 and GPR55 and (b) genes from various neurotransmitter systems that are likely to exert a non-specific influence on risk of cannabis use disorders, e.g. GABRA2, DRD2 and OPRM1. CONCLUSIONS: There are challenges associated with (i) understanding biological complexity underlying cannabis use disorders (including the need to study gene-gene and gene-environment interactions), (ii) using diagnostic versus quantitative phenotypes, (iii) delineating which stage of cannabis involvement (e.g. use versus misuse) genes influence and (iv) problems of sample ascertainment.
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A genetic variation of FAAH is associated with CUD.
“Studies have found that a genetic variation of fatty acid amine hydrolase (FAAH), the enzyme responsible for the degradation of endocannabinoids, is associated with CUD 77, 78.”
From Psychosocial and pharmacological interventions for the treatment of cannabis use disorder (2018) · cites this paper as [77]
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Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood
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- Authors
- Agrawal, A., & Lynskey, M. T.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Lynskey, Michael T.
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2009-03-17
- Volume
- 104
- Issue
- 4
- Pages
- 518-532
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- PMC
- PMC2703791
- OpenAlex
- W2036600731
- Cited by
- 128
- References
- 156
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 6 · 2020: 10 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 11 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 17
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addiction (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute on Drug Abuse (R01DA023668, R01DA018660, R01DA018267, DA 023668, DA18267, DA18660)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cannabis use disorder, candidate genes, genetic linkage, genetic association studies, heritability, monoglyceride lipase, ELTD1, CNR1, CB2, fatty acid amide hydrolase, TRPV1, GPR55, GABRA2, DRD2, OPRM1, gene-environment interaction, substance use disorders
- MeSH terms
- Gasdermins, Marijuana Abuse, Diseases in Twins, Genotype, Humans, Genetic Linkage, Receptors, Estrogen, Twin Studies as Topic
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