Cited by 128Cannabis and Cannabinoid ResearchGenetic Associations and EpidemiologySubstance Abuse Treatment and Outcomes

Candidate genes for cannabis use disorders: findings, challenges and directions.

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Agrawal, Arpana, Lynskey, Michael T.·2009·Addiction

Abstract

AIM: Twin studies have shown that cannabis use disorders (abuse/dependence) are highly heritable. This review aims to: (i) review existing linkage studies of cannabis use disorders and (ii) review gene association studies, to identify potential candidate genes, including those that have been tested for composite substance use disorders and (iii) to highlight challenges in the genomic study of cannabis use disorders. METHODS: Peer-reviewed linkage and candidate gene association studies are reviewed. RESULTS: Four linkage studies are reviewed: results from these have homed in on regions on chromosomes 1, 3, 4, 9, 14, 17 and 18, which harbor candidates of predicted biological relevance, such as monoglyceride lipase (MGLL) on chromosome 3, but also novel genes, including ELTD1[epidermal growth factor (EGF), latrophilin and seven transmembrane domain containing 1] on chromosome 1. Gene association studies are presented for (a) genes posited to have specific influences on cannabis use disorders: CNR1, CB2, FAAH, MGLL, TRPV1 and GPR55 and (b) genes from various neurotransmitter systems that are likely to exert a non-specific influence on risk of cannabis use disorders, e.g. GABRA2, DRD2 and OPRM1. CONCLUSIONS: There are challenges associated with (i) understanding biological complexity underlying cannabis use disorders (including the need to study gene-gene and gene-environment interactions), (ii) using diagnostic versus quantitative phenotypes, (iii) delineating which stage of cannabis involvement (e.g. use versus misuse) genes influence and (iv) problems of sample ascertainment.

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Crossref · 10.1111/j.1360-0443.2009.02504.x

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  1. [12]Terwilliger JD Ott J Handbook of Human Linkage Analysis. 1994 Johns Hopkins University Press Baltimore, MD
  2. [147]Karkowski LM Prescott CA Kendler KS Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs. Am J Med Genet 2000 96 665 670 11054775

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Authors
Agrawal, A., & Lynskey, M. T.
Affiliations
Washington University in St. Louis (US)
Venue
Addiction
Publisher
Wiley
Published
2009-03-17
Volume
104
Issue
4
Pages
518-532
ISSN
  • 0965-2140 (ISSN-L)
  • 1360-0443
OpenAlex
W2036600731
Cited by
128
References
156
Citations by year
2025: 3 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 6 · 2020: 10 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 11 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 17
FWCI
1.14
Type
journal article
Language
en
Open access
Locations
  • Addiction (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
National Institute on Drug Abuse (R01DA023668, R01DA018660, R01DA018267, DA 023668, DA18267, DA18660)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
cannabis use disorder, candidate genes, genetic linkage, genetic association studies, heritability, monoglyceride lipase, ELTD1, CNR1, CB2, fatty acid amide hydrolase, TRPV1, GPR55, GABRA2, DRD2, OPRM1, gene-environment interaction, substance use disorders
MeSH terms
Gasdermins, Marijuana Abuse, Diseases in Twins, Genotype, Humans, Genetic Linkage, Receptors, Estrogen, Twin Studies as Topic

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