Cited by 78Neurotransmitter Receptor Influence on BehaviorAttention Deficit Hyperactivity DisorderSchizophrenia research and treatment

Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood

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Nemoda, Zsofia, Szekely, Anna, Sasvari-Szekely, Maria·2011·Neuroscience & Biobehavioral Reviews

Abstract

Dopamine hypotheses of several psychiatric disorders are based upon the clinical benefits of drugs affecting dopamine transporter or receptors, and have prompted intensive candidate gene research within the dopaminergic system during the last two decades. The aim of this review is to survey the most important findings concerning dopaminergic gene polymorphisms in attention deficit hyperactivity disorder (ADHD), Tourette syndrome (TS), obsessive compulsive disorder, and substance abuse. Also, genetic findings of related phenotypes, such as inattention, impulsivity, aggressive behavior, and novelty seeking personality trait are presented, because recent studies have applied quantitative trait measures using questionnaires, symptom scales, or other objective endophenotypes. Unfortunately, genetic variants with minor effects are problematic to detect in these complex inheritance disorders, often leading to contradictory results. The most consistent association findings relate to ADHD and the dopamine transporter and the dopamine D4 receptor genes. Meta-analyses also support the association between substance abuse and the D2 receptor gene. The dopamine catabolizing enzyme genes, such as monoamine oxidase (MAO) A and catechol-O-methyltransferase (COMT) genes, have been linked to aggressive behaviors.

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Crossref · 10.1016/j.neubiorev.2011.04.002

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  • The length of the DRD4 repeat affects the activation of the receptor as well as the mRNA expression of the gene.

    “Several studies suggest that the length of the DRD4 repeat affects the activation of the receptor as well as the mRNA expression of the gene (Nemoda et al. 2011).”

    From The neurobiological link between OCD and ADHD (2014) · cites this paper as Nemoda et al. 2011

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Research works printed but not linked: 2

  1. Barr CL Feng Y Wigg KG Schachar R Tannock R Roberts W Malone M Kennedy JL 2001 5′-untranslated region of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder Am J Med Genet 105 84 90 11425008
  2. Bentivoglio M Morelli M Dunnett SB Bentivoglio M Björklund A Hökfelt T 2005 Neural wiring in the basal ganglia Dopamine Elsevier Amsterdam 38 44

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Authors
Nemoda, Z., Szekely, A., & Sasvari-Szekely, M.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2011-08
Volume
35
Issue
8
Pages
1665-1686
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2123345832
Cited by
78
References
285
Citations by year
2026: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 17 · 2013: 13 · 2012: 6
FWCI
1.22
Type
journal article
Language
en
Open access
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Fogarty International Center (R03TW007656)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
dopamine transporter gene, dopamine D4 receptor gene, dopamine D2 receptor gene, attention deficit hyperactivity disorder, Tourette syndrome, obsessive-compulsive disorder, substance abuse, inattention, impulsivity, aggression, novelty seeking, monoamine oxidase A, catechol-O-methyltransferase, endophenotypes, adolescence, early adulthood
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Critical Period, Psychological, Dopamine, Tourette Syndrome, Humans, Obsessive-Compulsive Disorder, Phenotype, Polymorphism, Genetic, Psychopathology, Receptors, Dopamine, Quantitative Trait, Heritable, Substance-Related Disorders, Young Adult, Dopaminergic Neurons

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