Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
Abstract
Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.
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GABAARs in brain reward circuits may be involved in the development of brain changes that mediate the addictive properties of drugs in general.
“The involvement of GABAAR genes in the abuse of and dependence on drugs that do not directly affect the GABAARs suggest that the GABAARs in brain reward circuits may be involved in the development of brain changes that mediate the addictive properties of drugs in general.”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [101]
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- Authors
- Agrawal, A., Edenberg, H. J., Foroud, T., Bierut, L. J., Dunne, G., Hinrichs, A. L., Nurnberger, J. I., Crowe, R., Kuperman, S., Schuckit, M. A., Begleiter, H., Porjesz, B., & Dick, D. M.
- Affiliations
- Indiana University School of Medicine (US)
- Washington University in St. Louis (US)
- University of Iowa (US)
- University of California San Diego (US)
- State University of New York (US)
- Corresponding author
- Dick, Danielle M.
- Venue
- Behavior Genetics
- Published
- 2006-04-19
- Volume
- 36
- Issue
- 5
- Pages
- 640-650
- ISSN
- 0001-8244 (ISSN-L)
- 1573-3297
- OpenAlex
- W2080590571
- Cited by
- 189
- References
- 53
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 23 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 11 · 2015: 12 · 2014: 15 · 2013: 19 · 2012: 13
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Behavior Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (U10 AA 08401, U10AA008401)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- GABRA2, chromosome 4, cannabis use disorder, illicit drug dependence, alcoholism, genetic association, single nucleotide polymorphisms, comorbidities, CoGa
- MeSH terms
- Alcoholism, Marijuana Abuse, Chromosome Mapping, Chromosomes, Human, Pair 4, DNA, Family, Female, Humans, Male, Pedigree, Phenotype, Receptors, GABA-A, Substance-Related Disorders, Polymorphism, Single Nucleotide
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