The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
Open accessAbstract
SUMMARY: Cytokines serve a central function as key factors in the regulation of the intestinal immune response and mediation of tissue damage in inflammatory bowel disease (IBD). Abnormalities in the expression of immunoregulatory cytokines such as IL-2, IL-4, IL-10 and interferon-gamma (IFN-γ) may indicate a dysregulation of intestinal immunity probably associated with pathogenic events. Therefore, cytokine mRNA concentrations were determined in the mucosa of patients with IBD at sites of active (n= 13) and inactive (n= 12) ulcerative colitis (UC), active (n= 11) and inactive (n= 11) Crohn's disease (CD) and in control patients (n= 14) using quantitative RT-PCR. IL-10 mRNA concentrations were significantly increased in patients with both active UC (P < 0.001) and active CD (P < 0.005) compared with control patients. IFN-γ mRNA concentrations were also significantly increased both in patients with active UC (P < 0.02) and active CD (P < 0.05) compared with control patients, whereas IL-2 mRNA levels were significantly (P < 0.02) increased only in active CD. IL-4 mRNA expression in the intestinal mucosa was frequently below the detection limit. Our results demonstrate that chronic intestinal inflammation in patients with CD is characterized by an increase of Th1-like cytokines. Furthermore, the increased IL-10 mRNA expression at sites of active IBD suggests that IL-10 is an important regulatory component involved in the control of the inflammatory response in inflammatory bowel disease.
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Cites
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Cited by
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Cytokine regulation of tight junctions
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Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function
Ewaschuk, J. B., Diaz, H., Meddings, L., Diederichs, B., Dmytrash, A., Backer, J., Looijer-van Langen, M., & Madsen, K. L. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90227.2008 · Cited by 590
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The anatomical basis of intestinal immunity
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Metadata
- Authors
- Niessner, M., & Volk, B. A.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-09
- Volume
- 101
- Issue
- 3
- Pages
- 428-435
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W1989210966
- Cited by
- 388
- References
- 46
- FWCI
- 13.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Niessner, M., & Volk, B. A. (2008). Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clinical and Experimental Immunology. https://doi.org/10.1111/j.1365-2249.1995.tb03130.x
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