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Cited by 99Asthma and respiratory diseasesAntioxidant Activity and Oxidative StressAir Quality and Health Impacts

Antioxidant supplementation and nasal inflammatory responses among young asthmatics exposed to high levels of ozone

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SIENRA-MONGE, J J, RAMIREZ-AGUILAR, M, MORENO-MACIAS, H, REYES-RUIZ, N I, DEL RÍO-NAVARRO, B E, RUIZ-NAVARRO, M X, HATCH, G, CRISSMAN, K +3 more·2004·Clinical and Experimental Immunology
DOI 10.1111/j.1365-2249.2004.02606.xPMC PMC1809210
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Abstract

The inflammatory response to ozone in atopic asthma suggests that soluble mediators of inflammation are released in response to oxidant stress. Antioxidants may alleviate additional oxidative stress associated with photochemical oxidant pollution. This study investigates the impact of antioxidant supplementation on the nasal inflammatory response to ozone exposure in atopic asthmatic children. We conducted a randomized trial using a double-blinded design. Children with asthma (n = 117), residents of Mexico City, were given randomly a daily supplement of vitamins (50 mg/day of vitamin E and 250 mg/day of vitamin C) or placebo. Nasal lavages were performed three times during the 4-month follow-up and analysed for content of interleukin-6 (IL-6), IL-8, uric acid and glutathione (GSx). IL-6 levels in the nasal lavage were increased significantly in the placebo group after ozone exposure while no increase was observed in the supplement group. The difference in response to ozone exposure between the two groups was significant (P = 0.02). Results were similar for IL-8, but with no significant difference between the groups (P = 0.12). GSx decreased significantly in both groups. Uric acid decreased slightly in the placebo group. Our data suggest that vitamin C and E supplementation above the minimum dietary requirement in asthmatic children with a low intake of vitamin E might provide some protection against the nasal acute inflammatory response to ozone.

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Crossref · 10.1111/j.1365-2249.2004.02606.x

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  • A randomized trial found that a daily supplement of vitamins C and E might provide some protection against acute nasal inflammatory response to ozone in asthmatic children.

    “A randomized trial found that a daily supplement of vitamins C and E might provide some protection against acute nasal inflammatory response to ozone in asthmatic children (84).”

    From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [84]

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Authors
SIENRA-MONGE, J. J., RAMIREZ-AGUILAR, M., MORENO-MACIAS, H., REYES-RUIZ, N. I., DEL RÍO-NAVARRO, B. E., RUIZ-NAVARRO, M. X., HATCH, G., CRISSMAN, K., SLADE, R., DEVLIN, R. B., & ROMIEU, I.
Affiliations
  • Hospital Infantil de México Federico Gómez (MX)
  • Instituto Nacional de Salud Pública de México
  • Hospital Infantil de México, Federico Gómez, México
  • Environmental Protection Agency (US)
  • Instituto Nacional de Salud Pública (MX)
Corresponding author
ROMIEU, I
ORCID
DEVLIN, R B
Venue
Clinical and Experimental Immunology
Publisher
Oxford University Press (OUP)
Published
2004-09-29
Volume
138
Issue
2
Pages
317-322
ISSN
  • 0009-9104 (ISSN-L)
  • 1365-2249
DOI
10.1111/j.1365-2249.2004.02606.x
PMC
PMC1809210
OpenAlex
W2119449792
Cited by
99
References
35
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 6
FWCI
2.47
Type
journal article
Language
en
Open access
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Clinical & Experimental Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Lincoln (University of Nebraska) (submittedVersion)
Funders
Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Keywords
antioxidant supplementation, vitamin E, vitamin C, ozone exposure, allergic asthma, children, nasal inflammation, oxidative stress, interleukin-6, interleukin-8, uric acid, glutathione, nasal irrigation, air pollution
MeSH terms
Air Pollutants, Antioxidants, Ascorbic Acid, Asthma, Child, Double-Blind Method, Environmental Exposure, Female, Glutathione, Humans, Male, Nasal Cavity, Ozone, Uric Acid, Vitamin E, Interleukin-6, Interleukin-8, Oxidative Stress, Dietary Supplements, alpha-Tocopherol

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