Mitogen activated protein kinases: a role in inflammatory bowel disease?

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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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MAP Kinases

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NF‐κB in inflammatory bowel disease

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Hippocampal mitogen-activated protein kinase activation is associated with intermittent hypoxia in a rat model of obstructive sleep apnea syndrome

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Augmentation of ADAMTS9 gene expression by IL‐1β is reversed by NFκB and MAPK inhibitors, but not PI3 kinase inhibitors

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Involvement of PPAR γ in the protective action of tropisetron in an experimental model of ulcerative colitis

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Targeting Mitogen-Activated Protein Kinases by Natural Products: A Novel Therapeutic Approach for Inflammatory Bowel Diseases

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Anti-inflammatory effect of the extracts from the branch of Taxillus yadoriki being parasitic in Neolitsea sericea in LPS-stimulated RAW264.7 cells

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Sinigrin Attenuates the Dextran Sulfate Sodium-induced Colitis in Mice by Modulating the MAPK Pathway

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Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies

Raj, V., Venkataraman, B., Ojha, S. K., Almarzooqi, S. S., Subramanian, V. S., al-Ramadi, B. K., Adrian, T. E., & Subramanya, S. B. (2023) · Molecules · doi:10.3390/molecules28072982 · Cited by 19

NPS2143 Inhibits MUC5AC and Proinflammatory Mediators in Cigarette Smoke Extract (CSE)-Stimulated Human Airway Epithelial Cells

Lee, J., Park, J., Kwon, O., Lee, H. J., Jeong, H. G., Kim, J., Oh, S., & Ahn, K. (2016) · Inflammation · doi:10.1007/s10753-016-0468-2 · Cited by 19

GLM, a novel luteolin derivative, attenuates inflammatory responses in dendritic cells: Therapeutic potential against ulcerative colitis

Kim, W. S., Song, H.-Y., Han, J. M., & Byun, E. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.012 · Cited by 19

New 2-amino-pyridinyl-N-acylhydrazones: Synthesis and identification of their mechanism of anti-inflammatory action

Cordeiro, N. D. M., de Freitas, R. H. C. N., Fraga, C. A. M., & Fernandes, P. D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109739 · Cited by 19

Protective effects of Amauroderma rugosum on dextran sulfate sodium-induced ulcerative colitis through the regulation of macrophage polarization and suppression of oxidative stress

Li, J., Luo, X., Shiu, P. H.-T., Cheng, Y., Nie, X., Rangsinth, P., Lau, B. W. M., Zheng, C., Li, X., Li, R., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116901 · Cited by 19

Experimental evidence of MAP kinase gene expression on the response of intestinal anti-inflammatory drugs

Quaglio, A. E. V., Castilho, A. C. S., & Stasi, L. C. D. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.06.012 · Cited by 15

Characterizing Clinical Features and Creating a Gene Expression Profile Associated With Pain Burden in Children With Inflammatory Bowel Disease

Grossi, V., Hyams, J. S., Glidden, N. C., Knight, B. E., & Young, E. E. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz240 · Cited by 14

Regulation of Intestinal Inflammation by Walnut-Derived Bioactive Compounds

Dai, K., Agarwal, N., Rodriguez-Palacios, A., & Basson, A. (2024) · Nutrients · doi:10.3390/nu16162643 · Cited by 13

Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease

Zhu, L., Li, Y., Zhou, L., Yang, G., Wang, Y., Han, J., Li, L., & Zhang, S. (2020) · Mediators of Inflammation · doi:10.1155/2020/5310180 · Cited by 14

Berberis lycium : A Miracle Medicinal Plant with Multifaceted Health Benefits

Ahmad, B., Murshed, A., Zaky, M. Y., Khan, I., Rahman, F. U., Abdellattif, M. H., Liu, G., & Lu, J. (2024) · Journal of Food Quality · doi:10.1155/2024/3152456 · Cited by 15

Supervised categorical principal component analysis for genome-wide association analyses

Lu, M., Lee, H., Hadley, D., Huang, J. Z., & Qian, X. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-s1-s10 · Cited by 13

Expression Profiling of Inflammatory and Immunological Genes in Collagenous Colitis

Liu, Q., & Harpaz, N. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy224 · Cited by 13

Moxibustion Eases Chronic Inflammatory Visceral Pain In Rats Via MAPK Signaling Pathway In The Spinal Cord

Huang, Y., Zhang, D., Li, Z., Yang, Y., Wu, L., Zhang, J., Zhi, F.-Y., Li, X.-Y., Shi, Z., Hong, J., et al. (2019) · Journal of Pain Research · doi:10.2147/jpr.s218588 · Cited by 13

Curcumin steers THP-1 cells under LPS and mTORC1 challenges toward phenotypically resting, low cytokine-producing macrophages

Kaur, H., & Moreau, R. F. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108553 · Cited by 13

Ameliorative Effect of Citropten Isolated from Citrusaurantifolia Peel Extract as a Modulator of T Cell and Intestinal Epithelial Cell Activity in DSS-Induced Colitis

Lee, H., Kim, E., & Jeong, G. (2022) · Molecules · doi:10.3390/molecules27144633 · Cited by 13

Protein Kinases and their Inhibitors Implications in Modulating Disease Progression

Ahsan, R., Khan, M. M., Mishra, A., Noor, G., & Ahmad, U. (2023) · The Protein Journal · doi:10.1007/s10930-023-10159-9 · Cited by 12

4‐O‐carboxymethylascochlorin protected against microglial‐mediated neurotoxicity in SH‐SY5Y and BV2 cocultured cells from LPS–induced neuroinflammation and death by inhibiting MAPK, NF‐κB, and Akt pathways

Park, J., Ha, S., Abekura, F., Lim, H., Chang, Y., Lee, M., Lee, M., Lee, Y., & Kim, C. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27464 · Cited by 12

Functional characterization of CXCR4 in mediating the expression of protein C system in experimental ulcerative colitis.

Lin, X., Wang, H., Li, Y., Yang, J., Yang, R., Wei, D., Zhang, J., Yang, D., Wang, B., Ren, X., et al. (2017) · Europe PMC (PubMed Central) · Cited by 11

Small-molecule modulators of INAVA cytosolic condensate and cell–cell junction assemblies

Chang, D., Luong, P., Li, Q., LeBarron, J., Anderson, M., Barrett, L. B., & Lencer, W. I. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202007177 · Cited by 11

Translational Relevance of Secondary Intracellular Signaling Cascades Following Traumatic Spinal Cord Injury

Zavvarian, M.-M., Modi, A. D., Sadat, S., Hong, J., & Fehlings, M. G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115708 · Cited by 12

3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells

Santarelli, R., Pompili, C., Montani, M. S. G., Evangelista, L., Gonnella, R., & Cirone, M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030663 · Cited by 11

Maleylated-BSA suppresses lipopolysaccharide-induced IL-6 production by activating the ERK-signaling pathway in murine RAW264.7 cells

Tada, R., Koide, Y., Yamamuro, M., Tanaka, R., Hidaka, A., Nagao, K., & Aramaki, Y. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2013.12.027 · Cited by 10

EPEC NleH1 is significantly more effective in reversing colitis and reducing mortality than NleH2 via differential effects on host signaling pathways

Kralicek, S. E., Nguyen, M., Rhee, K., Tapia, R., & Hecht, G. A. (2018) · Laboratory Investigation · doi:10.1038/s41374-017-0016-1 · Cited by 11

Synergistic Inhibitory Effect of Lactobacillus Cell Lysates and Butyrate on Poly I:C-Induced IL-8 Production in Human Intestinal Epithelial Cells

Park, S. W., Choi, Y. H., Gho, J. Y., Kang, G. A., & Kang, S. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10042-0 · Cited by 10

Mechanisms of human lymphotoxin beta receptor activation on upregulation of CCL5/RANTES production

Yeh, D. Y.-W., Wu, C., Chin, Y.-P., Lu, C.-J., Wang, Y., & Chen, M.-C. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.06.010 · Cited by 10

Zhumeria majdae essential oil attenuates TNBS-induced colitis in rats by regulating inflammatory and apoptotic pathways

Aghamiri, H., Mohammadgholi-Beiki, A., Rashidian, R., Motevalian, M., Rahimi‐Moghaddam, P., Sheibani, M., & Jafari‐Sabet, M. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01574-0 · Cited by 9

Chronic administration of Abarema cochliacarpos attenuates colonic inflammation in rats

da Silva, M. S., Sánchez‐Fidalgo, S., Cárdeno, A., Talero, E., da Silva, M. A., Vilegas, W., Brito, A. R. M. S., & Alarcón‐de‐la‐Lastra, C. (2011) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2011005000122 · Cited by 9

Canthin-6-one ameliorates TNBS-induced colitis in rats by modulating inflammation and oxidative stress. An in vivo and in silico approach

Arunachalam, K., Damazo, A. S., Macho, A., Matchado, M. S., Pavan, E., Figueiredo, F. D. F., Oliveira, D. M., Duckworth, C. A., Thangaraj, P., Leonti, M., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114490 · Cited by 9

Anti‑inflammatory effects of Daehwangmokdantang, a traditional herbal formulation, in lipopolysaccharide‑stimulated RAW 264.7 macrophages

Lee, M., Hong, S. H., Park, C., Han, M., Kim, S. O., Hong, S. H., Kim, G., & Choi, Y. H. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5296 · Cited by 9

Serum proteome of dogs with chronic enteropathy

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Casuarina glauca branchlets’ extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies

Mohamed, M. E., El-Shafae, A. M., Fikry, E., Elbaramawi, S. S., Elbatreek, M. H., & Tawfeek, N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1322181 · Cited by 8

Glucocorticoid-dependent transcription in skin requires epidermal expression of the glucocorticoid receptor and is modulated by the mineralocorticoid receptor

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Fructus sophorae attenuates secretion of proinflammatory mediators and cytokines through the modulation of NF-κB and MAPK signaling pathways in LPS-stimulated RAW 264.7 macrophages

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EBV infection of primary colonic epithelial cells causes inflammation, DDR and autophagy dysregulation, effects that may predispose to IBD and carcinogenesis

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Transcriptome analysis identifies genetic risk markers and explores the pathogenesis for inflammatory bowel disease.

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Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-γ Signaling

Kabel, A. M., Atef, A., Borg, H. M., El‐Sheikh, A. A. K., Khabbaz, H. J. A., Arab, H. H., & Estfanous, R. S. (2022) · Pharmaceuticals · doi:10.3390/ph15050600 · Cited by 7

miR-369-3p Ameliorates Inflammation and Apoptosis in Intestinal Epithelial Cells via the MEK/ERK Signaling Pathway

Scalavino, V., Piccinno, E., Giannelli, G., & Serino, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094288 · Cited by 6

Paenibacillus exopolysaccharide repairs GI inflammation by suppressing MAPK and NF-κB and restoring lipid production in Caco-2 cell line

Zhang, J., Li, Z.-Q., Zheng, R.-J., Jiang, J., Li, D., & Zhou, W.-W. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105709 · Cited by 6

RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation

Lei, Q.-Q., Hu, G., Chen, W., Yu, S.-X., Qi, S., Du, C., Gu, J., Lin, T., & Yang, Y. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.07.009 · Cited by 6

Potential Mechanisms of 3, 4-Oxo-Isopropylidene-Shikimic Acid in Ameliorating 2, 4, 6-Trinitrobenzenesulfonic Acid-Induced Colitis in Rats

Yan, Y., Wang, P., Sun, Y., Dong, Y., & Xing, J. (2019) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2019.0064 · Cited by 6

Continuous lifelong learning for modeling of gene regulation from single cell multiome data by leveraging atlas-scale external dataPreprint

Yuan, Q., & Duren, Z. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.01.551575 · Cited by 6

Alleviation of LPS-induced oxidative stress and inflammation by lesbicoumestan (7) via the increase of Nrf2 expression in mouse Kupffer cells

Li, X., Yao, L., Cho, Y.-C., Lee, D. Y., Cho, N., Yoo, G., Choi, S. Y., Yoon, S., & Lim, J. S. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117405 · Cited by 5

The effect of 4α,5α-epoxy-10α,14-dihydro-inuviscolide, a novel immunosuppressant isolated from Carpesium abrotanoides, on the cytokine profile in vitro and in vivo

Ko, Y., Oh, S., Song, H., Ryu, H. W., Ly, S. Y., & Kim, J. W. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.01.002 · Cited by 5

Chronic Exposure to Two Regimens of Waterpipe Smoke Elicits Lung Injury, Genotoxicity, and Mitochondrial Impairment with the Involvement of MAPKs Activation in Mice

Hamadi, N. K., Al‐Salam, S., Beegam, S., Zaaba, N. E., Elzaki, O., & Nemmar, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010430 · Cited by 4

Engineered an ultrasmall curcumin oral nanoformulation restores intestinal integrity and gut microbiota dysbiosis

Sharma, V., Prateeksha, P., Paliya, B. S., Gupta, S. C., Singh, S., Anunay, A., Agrahari, S., Singh, S. P., Rao, C. V., Barik, S. K., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102548 · Cited by 3

Herbal Medicines for the Management of Irritable Bowel Syndrome and Constipation Problem

Puppala, E. R., Prasad, N., Singh, M., Prakash, A. N., Abubakar, M., Adhikari, P., & Naidu, V. G. M. (2023) · Springer eBooks · doi:10.1007/978-981-99-7703-1_16 · Cited by 3

Dipeptidyl Peptidase IV in Inflammatory Bowel Diseases (DPP IV/CD26)

Pučar, L., Detel, D., & Varljen, J. (2012) · Archives of Industrial Hygiene and Toxicology · doi:10.2478/10004-1254-63-2012-2185 · Cited by 3

Protective effect of (E)-(2,4-dihydroxy)-α-aminocinnamic acid, a hydroxy cinnamic acid derivative, in an ulcerative colitis model induced by TNBS

Rivera-Antonio, A. M., Martínez, I. I. P., Márquez-Flores, Y. K., Solano, A. H. J., Torres-Ramos, M., & Rosales‐Hernández, M. C. (2024) · Bioscience Reports · doi:10.1042/bsr20240797 · Cited by 3

Therapeutic impacts of oral anti-diabetic drugs on Inflammatory Bowel Disease (IBD), a comprehensive review of clinical and preclinical studies

Niknejad, A., Hosseini, Y., Manesh, M. A. N., Navabakhsh, M., Peyrovinasab, A., Mavaddat, H., Miri, M. S., Hosseini, M., Büsselberg, D., & Abdolghaffari, A. H. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04591-0 · Cited by 2

Gene expression changes in mouse lung induced by subacute inhalation of PM10-rich particulate matter

Lee, J.-U., Hong, J.-S., Park, E., Baek, J., Choi, Y.-M., Chin, S.-S., Jeon, K.-J., Kim, W.-J., Park, S. W., & Jeong, S. (2024) · Inhalation Toxicology · doi:10.1080/08958378.2024.2410736 · Cited by 3

Anti-colitic effects of Centella asiatica (L.) Urb. juice via ERK/p38 and NF-κB signaling modulation and the characterization of a key marker compound

Shin, H. Y., Jeong, Y. Y., Kim, J., Shin, K., & Yu, K. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120657 · Cited by 2

Development and validation of a genomic nomogram based on a ceRNA network for comprehensive analysis of obstructive sleep apnea

Liu, W., Sun, X., Huang, J., Zhang, J., Liang, Z., Zhu, J., Chen, T., Zeng, Y., Peng, M., Li, X., et al. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1084552 · Cited by 2

Decoding non-coding SNPs: systems genomics modelling dissects the heterogeneity of IBD

Módos, D., Thomas, J. P., Brooks-Warburton, J., Poletti, M., Bohár, B., Liu, Y., Madgwick, M., Csabai, L., Kang, W.-X., Alexander-Dann, B., et al. (2025) · Molecular Systems Biology · doi:10.1038/s44320-025-00169-3 · Cited by 2

Flavonoid-rich extract of Cereus jamacaru: safety assessment and protective effects via NF-κB/MAPK modulation in an acute intestinal inflammation model

Melo, N. M. D. C., Araújo, D. F. D. S., Dantas-Medeiros, R., da Silva, V. C., Tavares, E. D. A., Pinheiro, F. A. S. D., Ferreira, L. D. S., Zanatta, A. C., de Moura, D. R., de Araujo, A. A., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121818 · Cited by 1

Inflammatory Bowel Disease: Pathobiology

Connelly, T. M., & Koltun, W. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-25970-3_44 · Cited by 1

Signaling Pathways in Clear Cell Renal Cell Carcinoma and Candidate Drugs Unveiled through Transcriptomic Network Analysis of Hub Genes

Suratos, K. S., Orda, M. A., Tsai, P., & Tayo, L. L. (2024) · Applied Sciences · doi:10.3390/app14198768 · Cited by 2

Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4/NF-κB-p65/iNOS and PPARγ/SIRT1 signaling pathways in ratsPreprint

Abdel‐Wahab, B. A., Alkahtani, S. A., Alqahtani, A. A., & Hassanein, E. H. M. (2021) · Research Square · doi:10.21203/rs.3.rs-619327/v1 · Cited by 1

Development of a Sensitive Cost-Effective Capture ELISA for Detection of Murine Monoclonal Antibodies - Correlation with SPR Biosensor Technology

Tsiamita, M., Pavlaki, M., Toloudi, M., Tiptiri-Kourpeti, A., Drossou, V., Apostolou, P., Chatziioannou, M. I., Ioannou, E., Papasotiriou, I., & Chlichlia, K. (2012) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/187152312803305722

The Homeostatic Protein Fam3D Orchestrates Colon Mucosal Protection Against Infection, Inflammation, and Carcinogenesis

Chen, K., Liang, W., Yoshimura, T., Gong, W., Huang, J., Difilippantonio, S., Jones, G. N., York, J., Trinchieri, G., Wang, Y., et al. (2023) · International Journal of Gastroenterology · doi:10.11648/j.ijg.20230701.11

Effect of whole sesame seeds on the expression of key genes in monocytes of dairy goats

Mitsiopoulou, C., Flemetakis, E., & Tsiplakou, E. (2024) · Small Ruminant Research · doi:10.1016/j.smallrumres.2024.107333

Growth factors and regulated cell death in neurodegenerative disorders

Numakawa, T., & Kajihara, R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32852-7.00010-3

Additional file 1 of The landscape of rare genetic variation associated with inflammatory bowel disease and Parkinson’s disease comorbidity

Kars, M. E., Wu, Y., Stenson, P. D., Cooper, D. N., Burisch, J., Peter, I., & Itan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25815101

Additional file 2 of The landscape of rare genetic variation associated with inflammatory bowel disease and Parkinson’s disease comorbidity

Kars, M. E., Wu, Y., Stenson, P. D., Cooper, D. N., Burisch, J., Peter, I., & Itan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25815588

Structural characterization of a low-methylated RG-I pectin from Sonchus oleraceus Linn. And its protective effects against DSS-induced colitis

Wu, Y., Li, Y., Wang, Y., & Wang, D. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107254

Effets de Saccharomyces boulardii CNCM I-745 sur le complexe d'adhérence E-cadhérine/caténines dans les maladies inflammatoires chroniques de l'intestin : impact sur la barrière épithéliale intestinale

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Identification des mécanismes moléculaires de neuroprotection modulés par l’activité dans deux maladies du motoneurone

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