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Cited by 75Adrenal and Paraganglionic TumorsAdrenal Hormones and DisordersPituitary Gland Disorders and Treatments

Reduced serum levels of dehydroepiandrosterone sulphate in adrenal incidentalomas: a marker of adrenocortical tumour.

Flecchla, D., Mazza, E., Carllni, M., Blatto, A., Ollvlerl, F., Serra:, G., Camannl, F., Messlna, M.·1995·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1995.tb01852.x
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Abstract

BACKGROUND AND OBJECTIVE: Reduced serum levels of dehydroepiandrosterone sulphate (DHEAS) have been shown in patients with Cushing's syndrome resulting from adrenocortical adenoma, in contrast with normal DHEAS levels in patients with Cushing's disease. The aim of this study was to verify whether patients with incidentally discovered adrenocortical adenomas also have reduced levels of DHEAS. DESIGN: Evaluation of serum DHEAS, serum and urinary cortisol, plasma ACTH and low dose dexamethasone suppression test in patients with adrenal incidentaloma and Cushing's syndrome. PATIENTS: Thirty-two patients with adrenal incidentaloma and, as controls, 17 patients with overt Cushing's syndrome, were studied. RESULTS: Serum DHEAS levels lower than normal were found in 21/24 (87.5%) patients with adrenocortical incidentaloma, but in only 1/8 patients with a mass of non-adrenocortical origin. This patient had massive bilateral metastatic infiltration of both adrenal glands and primary adrenal failure. The prevalence of low DHEAS levels in the two groups was significantly different (P = 0.0001). In patients with adrenocortical incidentaloma, the prevalence of low DHEAS levels was significantly higher (P = 0.0001) than that found for some hormonal alterations indicating pre-clinical hypercortisolism (high urinary cortisol, unsuppressed serum cortisol after low dose dexamethasone administration and low plasma ACTH). Low DHEAS levels were found in all patients with Cushing's syndrome due to adrenocortical adenoma but in none of those with Cushing's disease. CONCLUSIONS: Our results indicate that the finding of low DHEAS levels can be considered a marker of the adrenocortical origin of an adrenal incidentaloma, provided adrenal failure has been excluded.

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Crossref · 10.1111/j.1365-2265.1995.tb01852.x

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  • The 1-mg dexamethasone suppression test is the most used test for diagnosing subclinical hypercortisolism.

    “To date, the 1-mg DST is the most used test to diagnose SH, either alone (34 -36, 38, 44 -46) or in combination with other parameters (9, 18, 21, 32, 37, 39, 42, 49, 52-54, 56, 60, 61).”

    From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [36]

  • Low serum ACTH levels are frequently found in patients with adrenal incidentalomas.

    “Low serum ACTH levels are frequently found in AI patients (19,21,32,36,40,43,44,48,49,56,60,61).”

    From Diagnosis and Treatment of Subclinical Hypercortisolism (2011) · cites this paper as [36]

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Authors
Flecchla, D., Mazza, E., Carllni, M., Blatto, A., Ollvlerl, F., Serra:, G., Camannl, F., & Messlna, M.
Affiliations
  • Ospedale Maria Vittoria (IT)
  • University of Turin (IT)
Corresponding author
Mazza, E.
ORCID
Mazza, E.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1995-02
Volume
42
Issue
2
Pages
129-134
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1995.tb01852.x
OpenAlex
W2000175287
Cited by
75
References
25
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 3
FWCI
7.57
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4896 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
dehydroepiandrosterone sulfate, adrenal incidentaloma, adrenal adenoma, Cushing's syndrome, Cushing's disease, hypercortisolism, urinary cortisol, ACTH, dexamethasone suppression test, adrenal metastasis, adrenal insufficiency
MeSH terms
Adenoma, Adrenal Cortex Neoplasms, Adrenocorticotropic Hormone, Adult, Aged, Cushing Syndrome, Dehydroepiandrosterone, Female, Humans, Hydrocortisone, Hydroxyprogesterones, Male, Middle Aged, Biomarkers, Tumor, Dehydroepiandrosterone Sulfate, 17-alpha-Hydroxyprogesterone

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