CoChat
Sign Up
Cited by 278Pituitary Gland Disorders and TreatmentsHormonal Regulation and HypertensionAdrenal and Paraganglionic Tumors

The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.

High cardiovascular risk in patients with Cushing’s syndrome according to 1999 WHO/ISH guidelines

Mancini, Tatiana, Kola, Blerina, Mantero, Franco, Boscaro, Marco, Arnaldi, Giorgio·2004·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2004.02168.x
Open this paper in CoChat — free account

Abstract

OBJECTIVE: In patients with Cushing's syndrome (CS) cardiovascular complications determine a mortality rate four times higher than in an age- and gender-matched population. Therefore, we calculated the global cardiovascular risk in patients with CS. DESIGN AND PATIENTS: We applied the World Health Organization--International Society of Hypertension (WHO/ISH) 1999 guidelines for the estimation of cardiovascular risk in 38 females and 11 males with CS; 27 pituitary adenomas, 15 adrenal adenomas, four adrenal carcinomas and three ectopic ACTH-secreting tumours. The risk of major cardiovascular events was estimated considering the combined effect of several risk factors (hypertension, diabetes, etc.), organ damage (left ventricular hypertrophy (LVH), proteinuria, etc.) and associated pathologies. Four categories of absolute cardiovascular disease risk were defined (low, medium, high, very high). RESULTS: Eighty per cent of patients presented a 'high' or 'very high' cardiovascular risk; 85.1% of the patients were hypertensive with a mild-moderate hypertension (68%). Forty-seven per cent of patients were diabetics and 41.3% were obese. Hyperlipidaemia was less frequent (37.5%). Fasting glycaemia was the only cardiovascular risk factor that correlated with a degree of hypercortisolism. Duration of disease correlated with the presence of obesity (P < 0.0008) and hypertension (P < 0.03) but not with the presence of diabetes or dyslipidaemia and seemed to be the only significant predictor of cardiovascular risk (P = 0.03). CONCLUSIONS: Patients with active CS present a remarkably increased cardiovascular risk. Considering that the biochemical cure of hypercortisolism is often difficult to obtain, especially in Cushing's disease, and that cardiovascular risk could persist even after the 'cure', control of risk factors should be one of the primary goals of the therapy.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1365-2265.2004.02168.x

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 5

  1. 10.1046/j.1563-2571.2000.200106.x · DOI · Paper page
  2. 10.1210/jc.87.8.3662 · DOI
  3. 10.1210/jc.84.8.2664 · DOI
  4. 10.1210/jc.86.11.5301 · DOI
  5. Laragh J.H., 1995, Hypertension: Pathophysiology, Diagnosis and Management, 1987

Cited by

Sorted by citations

See all 278

Related

See all

Metadata

Authors
Mancini, T., Kola, B., Mantero, F., Boscaro, M., & Arnaldi, G.
Affiliations
  • Marche Polytechnic University (IT)
  • University of Padua (IT)
Corresponding author
Arnaldi, Giorgio
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2004-12
Volume
61
Issue
6
Pages
768-777
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2004.02168.x
OpenAlex
W2103539163
Cited by
278
References
40
Citations by year
2026: 11 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 16 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 16 · 2017: 15 · 2016: 15 · 2015: 24 · 2014: 15 · 2013: 15 · 2012: 17
FWCI
4.96
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
Keywords
Cushing's syndrome, cardiovascular risk, hypertension, diabetes mellitus, obesity, hyperlipidemia, left ventricular hypertrophy, proteinuria, hypercortisolism, disease duration, pituitary adenoma, adrenal adenoma, Cushing's disease, cardiovascular risk factors
MeSH terms
Adult, Cardiovascular Diseases, Cushing Syndrome, Diabetes Mellitus, Female, Humans, Hyperlipidemias, Hypertension, Male, Middle Aged, Obesity, Risk, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review