The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Androgens, insulin resistance and vascular disease in men
Abstract
Summary: Type 2 diabetes mellitus is increasing globally and is an established risk factor for the development of atherosclerotic vascular disease. Insulin resistance is the hallmark feature of type 2 diabetes and is also an important component of the metabolic syndrome. There is evidence to suggest that testosterone is an important regulator of insulin sensitivity in men. Observational studies have shown that testosterone levels are low in men with diabetes, visceral obesity (which is strongly associated with insulin resistance), coronary artery disease and metabolic syndrome. Short‐term interventional studies have also demonstrated that testosterone replacement therapy produces an improvement in insulin sensitivity in men. Thus hypotestosteronaemia may have a role in the pathogenesis of insulin‐resistant states and androgen replacement therapy could be a potential treatment that could be offered for improvements in glycaemic control and reduction in cardiovascular risk, particularly in diabetic men.
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“In addition, tobacco consumption has also been shown to exert effects on adrenal androgen secretion; in fact, high levels of androstenedione and dehydropiandrosterone sulfate (DHEAS) are usually found in smokers [40].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [40]
In the citing paper
“As increased high levels of circulating cortisol correlate with an increased risk of osteoporosis, this could represent a causal indirect effect of smoking contributing to the reduction of BMD [40,41].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [40]
In the citing paper
“It is being increasingly recognized that low testosterone levels in men are associated with reduced insulin sensitivity and type 2 diabetes (1).”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [1]
In the citing paper
“There is increased deposition of abdominal adipose tissue in hypogonadal subjects, which in turn leads to a further decrease in testosterone concentrations, through conversion to estradiol by aromatase.”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [1]
In the citing paper
“Studies of testosterone in non-(CHF) males suggest that physiological testosterone therapy improves insulin sensitivity.”
From The Effect of Testosterone on Insulin Sensitivity in Men with Heart Failure (2007) · cites this paper as [10]
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Metadata
- Authors
- Kapoor, D., Malkin, C. J., Channer, K. S., & Jones, T. H.
- Affiliations
- Barnsley Hospital NHS Foundation Trust (GB)
- Royal Hallamshire Hospital (GB)
- Corresponding author
- Jones, T. H.
- ORCID
- Jones, T. H.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2005-06-15
- Volume
- 63
- Issue
- 3
- Pages
- 239-250
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2137783284
- Cited by
- 317
- References
- 120
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 16 · 2014: 23 · 2013: 13 · 2012: 23
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgens, testosterone, insulin resistance, type 2 diabetes, atherosclerosis, coronary artery disease, metabolic syndrome, visceral obesity, hypogonadism, testosterone replacement therapy, glycemic control, cardiovascular risk, men
- MeSH terms
- Aged, Aging, Arteriosclerosis, Dehydroepiandrosterone, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Sex Hormone-Binding Globulin, Testosterone, Vascular Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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