The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Androgens, insulin resistance and vascular disease in men
Abstract
Summary: Type 2 diabetes mellitus is increasing globally and is an established risk factor for the development of atherosclerotic vascular disease. Insulin resistance is the hallmark feature of type 2 diabetes and is also an important component of the metabolic syndrome. There is evidence to suggest that testosterone is an important regulator of insulin sensitivity in men. Observational studies have shown that testosterone levels are low in men with diabetes, visceral obesity (which is strongly associated with insulin resistance), coronary artery disease and metabolic syndrome. Short‐term interventional studies have also demonstrated that testosterone replacement therapy produces an improvement in insulin sensitivity in men. Thus hypotestosteronaemia may have a role in the pathogenesis of insulin‐resistant states and androgen replacement therapy could be a potential treatment that could be offered for improvements in glycaemic control and reduction in cardiovascular risk, particularly in diabetic men.
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In the citing paper
“In addition, tobacco consumption has also been shown to exert effects on adrenal androgen secretion; in fact, high levels of androstenedione and dehydropiandrosterone sulfate (DHEAS) are usually found in smokers [40].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [40]
In the citing paper
“As increased high levels of circulating cortisol correlate with an increased risk of osteoporosis, this could represent a causal indirect effect of smoking contributing to the reduction of BMD [40,41].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [40]
In the citing paper
“It is being increasingly recognized that low testosterone levels in men are associated with reduced insulin sensitivity and type 2 diabetes (1).”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [1]
In the citing paper
“There is increased deposition of abdominal adipose tissue in hypogonadal subjects, which in turn leads to a further decrease in testosterone concentrations, through conversion to estradiol by aromatase.”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [1]
In the citing paper
“Studies of testosterone in non-(CHF) males suggest that physiological testosterone therapy improves insulin sensitivity.”
From The Effect of Testosterone on Insulin Sensitivity in Men with Heart Failure (2007) · cites this paper as [10]
Citations
Cites
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471
Impaired Insulin Action in Puberty
Amiel, S. A., Sherwin, R. S., Simonson, D. C., Lauritano, A. A., & Tamborlane, W. V. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150402 · Cited by 960
Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
Iannuzzi-Sucich, M., Prestwood, K. M., & Kenny, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.12.m772 · Cited by 890 · cited 1×
“Bioavailable and free testosterone measurements provide stronger correlations with parameters such as bone mineral density([9]) and muscle strength([10]) than total testosterone.”
BackgroundMalkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731
Self-citationAndrogens and Cardiovascular Disease
Liu, P. Y., Death, A. K., & Handelsman, D. J. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0005 · Cited by 695
PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-460 · Cited by 693
The assessment of insulin resistance in man
Wallace, T. M., & Matthews, D. R. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00745.x · Cited by 685
(1996) · PubMed · Cited by 643
Research works printed but not linked: 10
- 10.1080/713602987 · DOI
- 10.1210/jc.85.9.3276 · DOI
- 10.1210/jc.76.2.279 · DOI
- 10.1210/jc.79.1.265 · DOI
- Thaddea S., 1940, The effect of the sex hormones on metabolism in diabetes of late onset, Klinicheskaia Meditsina, 137, 760
- 10.1210/jc.74.2.362 · DOI
- 10.1210/jc.80.11.3373 · DOI
- 10.1080/713604785 · DOI
- Rayner M., 1998, British Heart Foundation Statistics Database
- Pugh P.J., 2003, High prevalence of low testosterone levels in men with coronary heart disease and an association with hypertension and obesity, Endocrine Abstracts, 5, P225
Cited by
Sorted by citations
Kapoor, D., Goodwin, E., Channer, K. S., & Jones, T. H. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02166 · Cited by 791
Self-citationTestosterone: a metabolic hormone in health and disease
Kelly, D. M., & Jones, T. H. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0455 · Cited by 612
Self-citationKelly, D. M., & Jones, T. H. (2015) · Obesity Reviews · doi:10.1111/obr.12282 · Cited by 487
Self-citationClinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes
Kapoor, D., Aldred, H., Clark, S., Channer, K. S., & Jones, T. H. (2007) · Diabetes Care · doi:10.2337/dc06-1426 · Cited by 493
Self-citationLow testosterone levels are common and associated with insulin resistance in men with diabetes
Grossmann, M., Thomas, M. C., Panagiotopoulos, S., Sharpe, K., MacIsaac, R. J., Clarke, S., Zajac, J. D., & Jerums, G. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2177 · Cited by 468
Metadata
- Authors
- Kapoor, D., Malkin, C. J., Channer, K. S., & Jones, T. H.
- Affiliations
- Barnsley Hospital NHS Foundation Trust (GB)
- Royal Hallamshire Hospital (GB)
- Corresponding author
- Jones, T. H.
- ORCID
- Jones, T. H.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2005-06-15
- Volume
- 63
- Issue
- 3
- Pages
- 239-250
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2137783284
- Cited by
- 317
- References
- 120
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 16 · 2014: 23 · 2013: 13 · 2012: 23
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgens, testosterone, insulin resistance, type 2 diabetes, atherosclerosis, coronary artery disease, metabolic syndrome, visceral obesity, hypogonadism, testosterone replacement therapy, glycemic control, cardiovascular risk, men
- MeSH terms
- Aged, Aging, Arteriosclerosis, Dehydroepiandrosterone, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Sex Hormone-Binding Globulin, Testosterone, Vascular Diseases
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