Cited by 317Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsSperm and Testicular Function

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Androgens, insulin resistance and vascular disease in men

Kapoor, D., Malkin, C. J., Channer, K. S., Jones, T. H.·2005·Clinical Endocrinology

DOI 10.1111/j.1365-2265.2005.02299.x

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Abstract

Summary: Type 2 diabetes mellitus is increasing globally and is an established risk factor for the development of atherosclerotic vascular disease. Insulin resistance is the hallmark feature of type 2 diabetes and is also an important component of the metabolic syndrome. There is evidence to suggest that testosterone is an important regulator of insulin sensitivity in men. Observational studies have shown that testosterone levels are low in men with diabetes, visceral obesity (which is strongly associated with insulin resistance), coronary artery disease and metabolic syndrome. Short‐term interventional studies have also demonstrated that testosterone replacement therapy produces an improvement in insulin sensitivity in men. Thus hypotestosteronaemia may have a role in the pathogenesis of insulin‐resistant states and androgen replacement therapy could be a potential treatment that could be offered for improvements in glycaemic control and reduction in cardiovascular risk, particularly in diabetic men.

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Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471
Impaired Insulin Action in Puberty
Amiel, S. A., Sherwin, R. S., Simonson, D. C., Lauritano, A. A., & Tamborlane, W. V. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150402 · Cited by 960
Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
Iannuzzi-Sucich, M., Prestwood, K. M., & Kenny, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.12.m772 · Cited by 890 · cited 1×
“Bioavailable and free testosterone measurements provide stronger correlations with parameters such as bone mineral density([9]) and muscle strength([10]) than total testosterone.”
Background
The Effect of Testosterone Replacement on Endogenous Inflammatory Cytokines and Lipid Profiles in Hypogonadal Men
Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731
Self-citation
Androgens and Cardiovascular Disease
Liu, P. Y., Death, A. K., & Handelsman, D. J. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0005 · Cited by 695
Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.
PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-460 · Cited by 693
The assessment of insulin resistance in man
Wallace, T. M., & Matthews, D. R. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00745.x · Cited by 685
Untitled work
(1996) · PubMed · Cited by 643
Frequent Occurrence of Hypogonadotropic Hypogonadism in Type 2 Diabetes
Dhindsa, S., Prabhakar, S., Sethi, M., Bandyopadhyay, A., Chaudhuri, A., & Dandona, P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0804 · Cited by 631
Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.
Stellato, R. K., Feldman, H. A., Hamdy, O., Horton, E. S., & McKinlay, J. B. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.490 · Cited by 618
Measures of Bioavailable Serum Testosterone and Estradiol and Their Relationships with Muscle Strength, Bone Density, and Body Composition in Elderly Men
van den Beld, A. W., de Jong, F. H., Grobbee, D. E., Pols, H. A. P., & Lamberts, S. W. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6825 · Cited by 618
Androgens and Coronary Artery Disease
Wu, F. C. W., & von Eckardstein, A. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0025 · Cited by 596
Endogenous Sex Hormones and the Development of Type 2 Diabetes in Older Men and Women: the Rancho Bernardo Study
Oh, J.-Y., Barrett-Connor, E., Wedick, N. M., & Wingard, D. L. (2002) · Diabetes Care · doi:10.2337/diacare.25.1.55 · Cited by 594
Low-Dose Transdermal Testosterone Therapy Improves Angina Threshold in Men With Chronic Stable Angina: A Randomized, Double-Blind, Placebo-Controlled Study
English, K. M., Steeds, R. P., Jones, T. H., Diver, M. J., & Channer, K. S. (2000) · Circulation · doi:10.1161/01.cir.102.16.1906 · Cited by 582
Self-citation
Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels
Seidell, J. C., Björntorp, P., Sjöström, L., Kvist, H., & Sannerstedt, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90297-p · Cited by 567
The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553
Increased Estrogen Production in Obese Men*
SCHNEIDER, G. T., Kirschner, M. A., Berkowitz, R. D., & Ertel, N. H. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-4-633 · Cited by 507
The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer
Smith, J. C., Bennett, S., Evans, L. M., Kynaston, H. G., Parmar, M., Mason, M. D., Cockcroft, J. R., Scanlon, M. F., & Davies, J. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7851 · Cited by 458
Effects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Disease
Webb, C. M., McNeill, J. G., Hayward, C. S., de Zeigler, D., & Collins, P. (1999) · Circulation · doi:10.1161/01.cir.100.16.1690 · Cited by 451
The Gonadotropic Function of Insulin*
Poretsky, L., & Kalin, M. F. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-132 · Cited by 449
Sex hormones, inflammation and the metabolic syndrome: a population-based study
Laaksonen, D., Niskanen, L., Punnonen, K., Nyyssonen, K., Tuomainen, T., Salonen, R., Rauramaa, R., & Salonen, J. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490601 · Cited by 438
Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men.
NESTLER, J. E., BARLASCINI, C. O., CLORE, J. N., & BLACKARD, W. G. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-57 · Cited by 414
Insulin and Risk of Cardiovascular Disease
Ruige, J. B., Assendelft, W. J., Dekker, J. M., Kostense, P. J., Heine, R. J., & Bouter, L. M. (1998) · Circulation · doi:10.1161/01.cir.97.10.996 · Cited by 393
Induction of insulin resistance by androgens and estrogens
Polderman, K. H., Gooren, L. J., Asscheman, H., Bakker, A., & Heine, R. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.1.8027240 · Cited by 382
Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency
Boyanov, M. A., Boneva, Z., & Christov, V. G. (2003) · The Aging Male · doi:10.1080/tam.6.1.1.7 · Cited by 381
Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study.
Barrett-Connor, E. L., & Khaw, K. (1988) · Circulation · doi:10.1161/01.cir.78.3.539 · Cited by 367
Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR)
Ferrannini, E., Vichi, S., Beck-Nielsen, H., Laakso, M., Paolisso, L., & Smith, G. (1996) · Diabetes · doi:10.2337/diab.45.7.947 · Cited by 353
Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms
English, K. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1873 · Cited by 350
Plasma Free and Non-Sex-Hormone-Binding-Globulin Bound Testosterone Are Decreased in Obese Men in Proportion to Their Degree of Obesity
ZUMOFF, B., STRAIN, G. W., MILLER, L. K., ROSNER, W., SENIE, R., SERES, D. S., & ROSENFELD, R. S. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-4-929 · Cited by 349
Effect of obesity and body fat distribution on sex hormones and insulin in men
Pasquali, R., Casimirri, F., Cantobelli, S., Melchionda, N., Labate, A. M. M., Fabbri, R., Capelli, M., & Bortoluzzi, L. (1991) · Metabolism · doi:10.1016/0026-0495(91)90199-7 · Cited by 337
Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens.
Mårin, P., Odén, B., & Björntorp, P. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829619 · Cited by 332 · cited 1×
“Testosterone inhibits the activity of lipoprotein lipase, the main enzymatic regulator of triglyceride uptake in adipose tissue.([64]) This Results in inhibition of triglyceride uptake, increase in lipid mobilization and a subsequent decrease in visceral adipose tissue mass (Fig.”
Background
Low Levels of Sex Hormone-binding Globulin and Testosterone Predict the Development of Non-Insulin-dependent Diabetes Mellitus in Men
Haffner, S. M., Shaten, J., Stem, M. P., Smith, G. D., Kuller, L., & MRFIT Research Group (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008832 · Cited by 320
Insulin Resistance, Body Fat Distribution, and Sex Hormones in Men
Haffner, S. M., Karhapää, P., Mykkänen, L. M., & Laakso, M. (1994) · Diabetes · doi:10.2337/diab.43.2.212 · Cited by 305
Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia
Dockery, F., Bulpitt, C. J., AGARWAL, S., Donaldson, M., & Rajkumar, C. (2003) · Clinical Science · doi:10.1042/cs20020209 · Cited by 294
Lower Endogenous Androgen Levels and Dyslipidemia in Men with Non-Insulin-Dependent Diabetes Mellitus
Barrett-Connor, E. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-10-807 · Cited by 281
Inverse Correlation between Serum Testosterone and Leptin in Men
Luukkaa, V., Pesonen, U., Huhtaniemi, I. T., Lehtonen, A., Tilvis, R. S., Tuomilehto, J., Koulu, M., & Huupponen, R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5134 · Cited by 281
Testosterone, body composition and aging.
Vermeulen, A. T., Goemaere, S., & Kaufman, J. (1999) · PubMed · Cited by 280
Testosterone concentrations in women and men with NIDDM
Andersson, B., Märin, P., Lissner, L., Vermeulen, A., & Björntorp, P. (1994) · Diabetes Care · doi:10.2337/diacare.17.5.405 · Cited by 268 · cited 1×
“Similarly, Andersson et al.([34]) found that total testosterone and SHBG levels were significantly lower in diabetic men than nondiabetic control subjects and had a negative correlation with insulin values.”
Background
Natural Androgens Inhibit Male Atherosclerosis
Alexandersen, P., Haarbo, J., Byrjalsen, I., Lawaetz, H., & Christiansen, C. (1999) · Circulation Research · doi:10.1161/01.res.84.7.813 · Cited by 251
The hypogonadal-obesity cycle: Role of aromatase in modulating the testosterone-estradiol shunt—A major factor in the genesis of morbid obesity
Cohen, P. G. (1999) · Medical Hypotheses · doi:10.1054/mehy.1997.0624 · Cited by 245
Contribution of Body Fatness and Adipose Tissue Distribution to the Age Variation in Plasma Steroid Hormone Concentrations in Men: The HERITAGE Family Study
Couillard, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.3.1026 · Cited by 237
Impact of Estrogen Replacement Therapy in a Male with Congenital Aromatase Deficiency Caused by a Novel Mutation in the CYP19 Gene
Herrmann, B. L., Saller, B., Janssen, O. E., Gocke, P., Bockisch, A., Sperling, H. V., Mann, K., & Broecker, M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020498 · Cited by 231
The Effects of Varying Doses of T on Insulin Sensitivity, Plasma Lipids, Apolipoproteins, and C-Reactive Protein in Healthy Young Men
Singh, A. B., Hsia, S. H., Alaupovic, P., Sinha‐Hikim, I., Woodhouse, L. J., Buchanan, T. A., Shen, R., Bross, R., Berman, N., & Bhasin, S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8172 · Cited by 225
Effect of testosterone on abdominal adipose tissue in men.
Rebuffé-Scrive, M., Mårin, P., & Björntorp, P. A. (1991) · PubMed · Cited by 223
Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men
Tsai, E., Boyko, E. J., Leonetti, D., & Fujimoto, W. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801183 · Cited by 221
Testosterone treatment for men with chronic heart failure
Pugh, P. J., Jones, R. D., West, J. N., Jones, T. H., & Channer, K. S. (2004) · Heart · doi:10.1136/hrt.2003.014639 · Cited by 221
Self-citation
Association between Plasma Total Testosterone and Cardiovascular Risk Factors in Healthy Adult Men: The Telecom Study
Simon, D. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.2.682 · Cited by 220
ENDOGENOUS SEX HORMONE LEVELS IN OLDER ADULT MEN WITH DIABETES MELLITUS
BARRETT-CONNOR, E., KHAW, K.-T., & YEN, S. S. C. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115732 · Cited by 217
Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men
Pasquali, R., Casimirri, F., De Iasio, R., Mesini, P., Boschi, S., Chierici, R., Flamia, R., Biscotti, M., & Vicennati, V (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.2.7852532 · Cited by 215
Obesity, body fat distribution and sex hormones in men.
Haffner, S. M., Valdez, R. A., D, M. P. S. M., & Katz, M. S. (1993) · PubMed · Cited by 213
Sex differences in the association of endogenous sex hormone levels and glucose tolerance status in older men and women.
Goodman‐Gruen, D., & Barrett-Connor, E. L. (2000) · Diabetes Care · doi:10.2337/diacare.23.7.912 · Cited by 202
Insulin Resistance and Diminished Glucose Tolerance in Powerlifters Ingesting Anabolic Steroids*
Cohen, J. C., & HICKMAN, R. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-5-960 · Cited by 202
Sex hormone-binding globulin: a marker for hyperinsulinemia and/or insulin resistance?
Nestler, J. E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8432767 · Cited by 201
Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues.
Mårin, P., Krotkiewski, M., & Björntorp, P. A. (1992) · PubMed · Cited by 192
The effects of testosterone on insulin sensitivity in male rats
Holmäng, A. B., & Björntorp, P. A. (1992) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1992.tb09452.x · Cited by 189
Sex Steroid Hormones, Upper Body Obesity, and Insulin Resistance
Abate, N., Haffner, S. M., Garg, A., Peshock, R. M., & Grundy, S. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020567 · Cited by 187
Acute haemodynamic effects of testosterone in men with chronic heart failure
Pugh, P. J. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00083-6 · Cited by 184
Testosterone is a potent inhibitor of L-type Ca2+ channels
Scragg, J. L., Jones, R. D., Channer, K. S., Jones, T. H., & Peers, C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.054 · Cited by 170
Self-citation
Level of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes
Birkeland, K. I., Hanssen, K. F., Torjesen, P. A., & Vaaler, S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8432768 · Cited by 161 · cited 1×
“,([32]) using the insulinglucose clamp technique, demonstrated an inverse correlation between insulin resistance and serum SHBG levels in 23 type 2 diabetic men”
Method
Inverse Correlation between Serum Testosterone and Leptin in Men
Luukkaa, V. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3243 · Cited by 161
Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study
Simon, D., Preziosi, P., Barrett-Connor, E., Roger, M., Saint-Paul, M., Nahoul, K., & Papoz, L. (1992) · Diabetologia · doi:10.1007/bf00402551 · Cited by 157
Dehydroepiandrosterone Sulfate and Aging
Vermeulen, A. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17376.x · Cited by 157
The vasodilatory action of testosterone: a potassium‐channel opening or a calcium antagonistic action?
Jones, R. D., Pugh, P. J., Jones, T. H., & Channer, K. S. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705141 · Cited by 153
Self-citation
Dehydroepiandrosterone Supplementation Improves Endothelial Function and Insulin Sensitivity in Men
Kawano, H., Yasue, H., Kitagawa, A., Hirai, N., Yoshida, T., Soejima, H., Miyamoto, S., Nakano, M., & Ogawa, H. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021603 · Cited by 142
Differential contribution of testosterone and estradiol in the determination of cholesterol and lipoprotein profile in healthy middle-aged men
Pottelbergh, I. V., Braeckman, L., Bacquer, D. D., Backer, G. D., & Kaufman, J. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00308-8 · Cited by 137
Androgen Therapy Improves Insulin Sensitivity and Decreases Leptin Level in Healthy Adult Men With Low Plasma Total Testosterone
Simon, D., Charles, M.-A., Lahlou, N., Nahoul, K., Oppert, J.-M., Gouault-Heilmann, M., Lemort, N., Thibult, N., Joubert, E., Balkau, B., et al. (2001) · Diabetes Care · doi:10.2337/diacare.24.12.2149 · Cited by 136 · cited 2×
“Simon et al.84 randomized 18 men to one of three treatment groups – testosterone, dihydrotestosterone and placebo, administered in the form of gel.”
Background
A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men
Morris, P., Malkin, C., Channer, K., & Jones, T. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510241 · Cited by 122
Self-citation
The Pituitary-Gonadal Axis and Health in Elderly Men: A Study of Men Born in 1913
Tibblin, G., Adlerberth, A., Lindstedt, G., & Björntorp, P. A. (1996) · Diabetes · doi:10.2337/diab.45.11.1605 · Cited by 119
Relationships in men of sex hormones, insulin, adiposity, and risk factors for myocardial infarction
Phillips, G. B., Jing, T.-Y., & Heymsfield, S. B. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00072-6 · Cited by 118
Reversal of the hypogonadotropic hypogonadism of obese men by administration of the aromatase inhibitor testolactone
Zumoff, B., Miller, L. K., & Strain, G. W. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00186-0 · Cited by 118
Relationship between serum sex hormones and the glucose-insulin-lipid defect in men with obesity
Phillips, G. B. (1993) · Metabolism · doi:10.1016/0026-0495(93)90181-m · Cited by 116
Hormonal Abnormalities in Obesity
Zumoff, B. (1987) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1987.tb05939.x · Cited by 109
Dehydroepiandrosterone and ageing
Arlt, W. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.02.006 · Cited by 108
Effects of short-term testosterone exposure on insulin sensitivity of muscles in female rats
Holmäng, A. B., Larsson, B., Brzezinska, Z., & Björntorp, P. A. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.6.e851 · Cited by 107
Androgens and abdominal obesity
Mrin, P., & Arver, S. (1998) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(98)80191-2 · Cited by 106
Effect of Massive Weight Loss on Hypothalamic Pituitary-Gonadal Function in Obese Men*
STRAIN, G. W., ZUMOFF, B., MILLER, L. K., ROSNER, W., LEVIT, C., KALIN, M., HERSHCOPF, R. J., & ROSENFELD, R. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-5-1019 · Cited by 103
Partial androgen deficiency in aging type 2 diabetic men and its relationship to glycemic control
Corrales, J. J., Burgo, R. M., Garcı́a-Berrocal, B., Almeida, M., Alberca, I., González-Buitrago, J. M., Orfao, A., & Miralles, J. M. (2004) · Metabolism · doi:10.1016/j.metabol.2003.12.016 · Cited by 97
Insulin inhibits adrenal 17,20-lyase activity in man
Nestler, J. E., McClanahan, M. A., Clore, J. N., & Blackard, W. G. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.2.1730815 · Cited by 96
Haemostatic Effects of Supraphysiological Levels of Testosterone in Normal Men
Anderson, R. A., Ludlam, C. A., & Wu, F. C. W. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649799 · Cited by 95
Lack of effect of dehydroepiandrosterone in obese men.
Usiskin, K., Butterworth, S., Clore, J. N., Arad, Y., Ginsberg, H. N., Blackard, W. G., & Nestler, J. (1990) · PubMed · Cited by 84
Relation of Steroid Hormones to Glucose Tolerance and Plasma Insulin Levels in Men: Importance of visceral adipose tissue
Tchernof, A., Despres, J., Dupont, A., Bélanger, A., Nadeau, A., Prud'homme, D., Moorjani, S., Lupien, P., & Labrie, F. (1995) · Diabetes Care · doi:10.2337/diacare.18.3.292 · Cited by 83
Androgen plasma levels in male diabetics
Andò, S., Rubens, R., & Rottiers, R. (1984) · Journal of Endocrinological Investigation · doi:10.1007/bf03348370 · Cited by 82
Decreased Androgen Levels and Obesity in Men
Vermeulen, A. (1996) · Annals of Medicine · doi:10.3109/07853899608999068 · Cited by 82
The Administration of Pharmacological Doses of Testosterone or 19-Nortestosterone to Normal Men is Not Associated with Increased Insulin Secretion or Impaired Glucose Tolerance*
Friedl, K. E., JONES, R. E., Hannan, C. J., & Plymate, S. R. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-5-971 · Cited by 80
Glucose Intolerance and Insulin Resistance in Aplastic Anemia Treated with Oxymetholone*
WOODARD, T. L., Burghen, G. A., Kitabchi, A. E., & Wilimas, J. A. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-5-905 · Cited by 79
Impact of obesity on hypogonadism in the andropause
TAN, R. S.-H., & Pu, S. J. (2002) · International Journal of Andrology · doi:10.1046/j.1365-2605.2002.00356.x · Cited by 76
Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency?
den Saffele, J. K. V., Goemaere, S., Bacquer, D. D., & Kaufman, J. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00741.x · Cited by 71
Effect of Testosterone Replacement on Whole Body Glucose Utilisation and Other Cardiovascular Risk Factors in Males with Idiopathic Hypogonadotrophic Hypogonadism
Tripathy, D., Shah, P., Lakshmy, R., & Reddy, K. (1998) · Hormone and Metabolic Research · doi:10.1055/s-2007-978950 · Cited by 66
Insulin regulation of Leydig cell luteinizing hormone receptors.
Charreau, E. H., Calvo, J. C., Tesone, M., Valle, L. B. D. S., & Barañao, J. L. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40846-5 · Cited by 65
UK Prospective Diabetes Study. IV. Characteristics of Newly presenting Type 2 Diabetic Patients: Male Preponderance and Obesity at Different Ages
Multi-centre Study (1988) · Diabetic Medicine · doi:10.1111/j.1464-5491.1988.tb00963.x · Cited by 64
Relationship of insulin secretory pulses to sex hormone-binding globulin in normal men
Peiris, A. N., Stagner, J. I., Plymate, S. R., Vogel, R. L., Heck, M., & Samols, E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8432769 · Cited by 62
Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross-sectional Italian study of a general elderly population
Ravaglia, G., Forti, P., Maioli, F., Sacchetti, L., Nativio, V., Scali, C. R., Mariani, E., Zanardi, V., Stefanini, A., & Macini, P. L. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00232-7 · Cited by 61
Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S: effects on fat distribution, insulin sensitivity and lipid metabolism
Jędrzejuk, D., Mędraś, M., Milewicz, A., & Demissie, M. (2003) · The Aging Male · doi:10.1080/tam.6.3.151.156 · Cited by 53
Low testosterone and insulin resistance in hypertension-prone men.
Endre, T., Mattiasson, I., Berglund, G., & Hulthén, U. L. (1996) · PubMed · Cited by 52
Glucose Handling, Diabetes and Ageing
Paolisso, G., Scheen, A. J., & BVRE, P. L. (2008) · Hormone Research · doi:10.1159/000184237 · Cited by 49
Disparate effects of weight reduction by diet on serum dehydroepiandrosterone-sulfate levels in obese men and women
Jakubowicz, D. J., Beer, N., Beer, R. M., & Nestler, J. E. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.11.7593454 · Cited by 46
Testosterone for secondary prevention in men with ischaemic heart disease?
Malkin, C. J., Pugh, P. J., Jones, T. H., & Channer, K. S. (2003) · QJM · doi:10.1093/qjmed/hcg086 · Cited by 45
Self-citation
Nandrolone, a 19-nortestosterone, enhances insulin-independent glucose uptake in normal men.
Hobbs, C. J., Jones, R. E., & Plymate, S. (1996) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.81.4.8636371 · Cited by 43
Effects of anabolic steroid, methandienone, on carbohydrate metabolism in man.
Landon, J., WYNN, V., Jn, C., & KENNEDY, A. (1962) · PubMed · Cited by 43
Hormonal Changes in Elderly Men with Non-Insulin-Dependent Diabetes mellitus and the Hormonal Relationships to Abdominal Adiposity
Chang, T., Tung, C.-C., & Hsiao, Y. (2009) · Gerontology · doi:10.1159/000213594 · Cited by 41
Low testosterone levels in diabetic men and animals: a possible role in testicular impotence
Fushimi, H., Horie, H., Inoue, T., Kameyama, M., Kanao, K., ISHIHARA, S., Tsujimura, T., Nunotani, H., Minami, T., Okazaki, Y., et al. (1989) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(89)90069-7 · Cited by 40
Metabolic effects of nandrolone decanoate and resistance training in men with HIV
Sattler, F. R., Schroeder, E. T., Dubé, M. P., Jaque, S. V., Martinez, C., Blanche, P. J., Azen, S. P., & Krauss, R. M. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00189.2002 · Cited by 39
Acute hyperinsulinemia, androgen homeostasis and insulin sensitivity in healthy man
Ebeling, P. R., Stenman, U.-H., Seppälä, M., & Koivisto, V. A. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1460063 · Cited by 37
Insulin action and dynamics modelled in patients taking the anabolic steroid methandienone (Dianabol)
Godsland, I., Shennan, N. M., & Wynn, V. (1986) · Clinical Science · doi:10.1042/cs0710665 · Cited by 31
Effect of hormone replacement therapy on insulin secretion and insulin sensitivity in postmenopausal diabetic women
Borissova, A.-M., Tankova, T. I., Kamenova, P., Dakovska, L. N., Kovatcheva, R. D., Кirilov, G., Генов, Н., Milcheva, B., & Koev, D. (2002) · Gynecological Endocrinology · doi:10.1080/gye.16.1.67.74 · Cited by 30
on Serum Concentrations of Testosterone and Dihydrotestosterone and Testicular 3β-Hydroxysteroid Dehydrogenase Activity in Intact and Hypophysectomized Diabetic Rats
BLANCO, F. L., Fanjul, L. F., & de Galarreta, R. (1981) · Endocrinology · doi:10.1210/endo-109-4-1248 · Cited by 28
Association of increased C-peptide serum levels and testosterone in type 2 diabetes.
Zietz, B., Cuk, A., Hügl, S., Büttner, R., Straub, R., Bauer, B., Daffner, P., Schölmerich, J., & Palitzsch, K. (2000) · European journal of internal medicine · doi:10.1016/s0953-6205(00)00122-9 · Cited by 27
Endocrine abnormalities in healthy first‐degree relatives of type 2 diabetes patients – potential role of steroid hormones and leptin in the development of insulin resistance
Jansson, P.-A., Eliasson, B., Lindmark, S., & Eriksson, J. W. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.00963.x · Cited by 26
Effect of surgical castration on risk factors for arteriosclerosis of patients with prostate cancer.
Xu, T., Wang, X., Hou, S.-K., Zhu, J.-C., Zhang, X., & Huang, X. (2002) · PubMed · Cited by 25
Oestradiol Levels in Diabetic Men with and without a Previous Mocardial Infarction
SMALL, M. P., MacRury, S. M., Beastall, G. H., & MacCuish, A. C. (1987) · QJM · doi:10.1093/oxfordjournals.qjmed.a068132 · Cited by 22
Insulin resistance and cardiovascular disease
Laakso, M. (2002) · The British Journal of Diabetes · doi:10.1177/1474651402002001s0301 · Cited by 22
Nandrolone, a 19-nortestosterone, enhances insulin-independent glucose uptake in normal men
Hobbs, C. J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.4.1582 · Cited by 19
Androgen Effect on Insulin Action and Glucose Metabolism
Rizza, R. A. (2000) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(19)30645-7 · Cited by 16
Diabetes helpline
Rai, B., & Robinson, N. (2002) · The British Journal of Diabetes · doi:10.1177/14746514020020010301 · Cited by 8
Review: Type 2 diabetes — implications for macrovascular mechanics and disease
Nicolaides, E., & Jones, C. J. H. (2002) · The British Journal of Diabetes · doi:10.1177/14746514020020011101 · Cited by 8
Effects of long term administration of testosterone enanthate on glucose metabolism in rhesus monkeys
Tyagi, A., Rajalakshmi, M., Jeyaraj, D. A., Sharma, R. S., & Bajaj, J. S. (1999) · Contraception · doi:10.1016/s0010-7824(99)00038-4 · Cited by 7
Serum androgen levels after streptozotocin administration in the male rat.
Centol, I., López, F., Déniz, A., Benítez, L., Marrero, I., Fanjul, L. F., & de Galarreta, C. M. R. (1988) · PubMed · Cited by 4
Untitled work
Alberti (1998) · doi:10.1002/(sici)1096-9136(199807)15:7

Research works printed but not linked: 10

10.1080/713602987 · DOI
10.1210/jc.85.9.3276 · DOI
10.1210/jc.76.2.279 · DOI
10.1210/jc.79.1.265 · DOI
Thaddea S., 1940, The effect of the sex hormones on metabolism in diabetes of late onset, Klinicheskaia Meditsina, 137, 760
10.1210/jc.74.2.362 · DOI
10.1210/jc.80.11.3373 · DOI
10.1080/713604785 · DOI
Rayner M., 1998, British Heart Foundation Statistics Database
Pugh P.J., 2003, High prevalence of low testosterone levels in men with coronary heart disease and an association with hypertension and obesity, Endocrine Abstracts, 5, P225

Sorted by citations

Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
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Self-citation
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Kelly, D. M., & Jones, T. H. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0455 · Cited by 612
Self-citation
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Kelly, D. M., & Jones, T. H. (2015) · Obesity Reviews · doi:10.1111/obr.12282 · Cited by 487
Self-citation
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Kapoor, D., Aldred, H., Clark, S., Channer, K. S., & Jones, T. H. (2007) · Diabetes Care · doi:10.2337/dc06-1426 · Cited by 493
Self-citation
Low testosterone levels are common and associated with insulin resistance in men with diabetes
Grossmann, M., Thomas, M. C., Panagiotopoulos, S., Sharpe, K., MacIsaac, R. J., Clarke, S., Zajac, J. D., & Jerums, G. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2177 · Cited by 468

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Authors: Kapoor, D., Malkin, C. J., Channer, K. S., & Jones, T. H.
Affiliations: Barnsley Hospital NHS Foundation Trust (GB)
Royal Hallamshire Hospital (GB)
Corresponding author: Jones, T. H.
ORCID: Jones, T. H.
Venue: Clinical Endocrinology
Publisher: Wiley
Published: 2005-06-15
Volume: 63
Issue: 3
Pages: 239-250
ISSN: 0300-0664 (ISSN-L)
1365-2265
DOI: 10.1111/j.1365-2265.2005.02299.x
OpenAlex: W2137783284
Cited by: 317
References: 120
Citations by year: 2026: 3 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 16 · 2014: 23 · 2013: 13 · 2012: 23
FWCI: 3.27
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Clinical Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgens, testosterone, insulin resistance, type 2 diabetes, atherosclerosis, coronary artery disease, metabolic syndrome, visceral obesity, hypogonadism, testosterone replacement therapy, glycemic control, cardiovascular risk, men
MeSH terms: Aged, Aging, Arteriosclerosis, Dehydroepiandrosterone, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Sex Hormone-Binding Globulin, Testosterone, Vascular Diseases

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Androgens, insulin resistance and vascular disease in men

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