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Cited by 117Thyroid Disorders and TreatmentsBlood Pressure and Hypertension StudiesThyroid and Parathyroid Surgery

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Subclinical thyroid dysfunction and blood pressure: a community‐based study

Walsh, John P., Bremner, Alexandra P., Bulsara, Max K., O’Leary, Peter, Leedman, Peter J., Feddema, Peter, Michelangeli, Valdo·2006·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2006.02619.x
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Abstract

Objective Overt hypothyroidism and hyperthyroidism are associated with hypertension, but it is uncertain whether the same is true of subclinical hypothyroidism and hyperthyroidism. Design, subjects and measurements Cross‐sectional study of 2033 participants (aged 17–89 years) in the Busselton Thyroid Study who did not have a history of thyroid disease. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and the prevalence of hypertension (defined as SBP 140 mmHg, DBP 90 mmHg or on treatment for hypertension) in subjects with thyroid dysfunction and euthyroid subjects were compared using linear regression models. Subjects with treated hypertension (N = 299) were excluded from analyses of SBP and DBP but included in analyses of hypertension prevalence. Results Mean SBP, DBP and the prevalence of hypertension did not differ significantly between subjects with subclinical hypothyroidism (N = 105) and euthyroid subjects (N = 1859), nor did they differ between subjects with serum TSH concentrations in the upper reference range (2·0–4·0 mU/l; N = 418) and those with TSH concentrations in the lower reference range (0·4–2·0 mU/l; N = 1441). The prevalence of hypertension was higher in subjects with subclinical hyperthyroidism than euthyroid subjects (prevalence odds ratio 2·8, 95% confidence interval 1·3–6·0 adjusted for age, age 2 and sex), but this was based on a small number of subjects with subclinical hyperthyroidism (N = 35). Conclusions Subclinical hypothyroidism is not associated with hypertension. The observed association between subclinical hyperthyroidism and hypertension requires confirmation in a larger sample.

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  1. Knudsen N., 2005, Elevated blood pressure is associated with small differences in TSH in a general population, Thyroid, 15, S

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Metadata

Authors
Walsh, J. P., Bremner, A. P., Bulsara, M. K., O’Leary, P., Leedman, P. J., Feddema, P., & Michelangeli, V.
Affiliations
The University of Western Australia (AU)
Corresponding author
Walsh, John P.
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2006-09-05
Volume
65
Issue
4
Pages
486-491
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2006.02619.x
OpenAlex
W1989249037
Cited by
117
References
39
Citations by year
2024: 3 · 2023: 6 · 2022: 9 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 6
FWCI
4.98
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders
Merck Sharp and Dohme
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
subclinical hypothyroidism, subclinical hyperthyroidism, hypertension, blood pressure, thyroid-stimulating hormone, thyroid dysfunction
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Diastole, Female, Health Surveys, Humans, Hypertension, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Risk, Systole, Thyroid Diseases, Thyrotropin, Thyroxine, Western Australia, Odds Ratio

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