The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic Syndrome
Abstract
Soluble protein hormones are key regulators of a number of metabolic processes, including food intake and insulin sensitivity. We have used a signal sequence trap to identify genes that encode secreted or membrane-bound proteins in Psammomys obesus, an animal model of obesity and type 2 diabetes (T2D). Using this signal sequence trap, we identified the chemokine chemerin as being a novel adipokine. Gene expression of chemerin and its receptor, chemokine-like receptor 1 (CMKLR1), was significantly higher in adipose tissue of obese and type 2 diabetic P. obesus compared with lean, normoglycemic P. obesus. Fractionation of P. obesus adipose tissue confirmed that chemerin was predominantly expressed in adipocytes, whereas CMKLR1 was expressed in both adipocytes and stromal-vascular cells of adipose tissue. In 3T3-L1 adipocytes, chemerin was markedly induced during differentiation, whereas CMKLR1 was down-regulated during differentiation. Serum chemerin levels were measured by ELISA in human plasma samples from 114 subjects with T2D and 142 normal glucose tolerant controls. Plasma chemerin levels were not significantly different between subjects with T2D and normal controls. However, in normal glucose tolerant subjects, plasma chemerin levels were significantly associated with body mass index, circulating triglycerides, and blood pressure. Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome.
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Cites
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BackgroundSerum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
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Cited by
Adipose tissue inflammation and metabolic dysfunction in obesity
Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021
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Adipokine dysregulation and adipose tissue inflammation in human obesity
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Metadata
- Authors
- Bozaoglu, K., Bolton, K., McMillan, J., Zimmet, P., Jowett, J., Collier, G., Walder, K., & Segal, D.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-10-01
- Volume
- 148
- Issue
- 10
- Pages
- 4687-4694
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2119773094
- Cited by
- 858
- References
- 9
- FWCI
- 14.03
- Type
- journal article
- Language
- en
- Open access
- closed
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